{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679487765504.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4164/sptj.29.456"}},{"identifier":{"@type":"NAID","@value":"130003952052"}}],"dc:title":[{"@language":"en","@value":"Changes in Controlled-release Functions of Pulverized Low-substituted Hydroxypropylcellulose by Wet Granulation."},{"@value":"コントロールリリース基剤としての微粉化低置換度ヒドロキシプロピルセルロース（Ｌ‐ＨＰＣ）の湿式造粒による徐放性能変化"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Pulverized L-HPC (low-substituted hydroxypropylcellulose, LH41) is used as a controlled-release matrix filler, depending on the amount of loading in its formulation. The flowability and packability of the L-HPC particles in drugs were facilitated by wet granulation to improve their availabilities for practical uses. Controlled-release functions of the L-HPC were reserved through granulation with ethanol, whereas they were lost during granulation with water. The differences in the controlled release functions of agglomerated L-HPC were explained in terms of their swelling properties, depending on the type of slovent used for the granulation."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679487765504","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254730290"}],"foaf:name":[{"@language":"en","@value":"KAWASHIMA Yoshiaki"},{"@language":"ja","@value":"川島 嘉明"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gifu Pharmaceutical Univ., Phamaceutical 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Tomoaki"},{"@language":"ja","@value":"日野 知証"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gifu Pharmaceutical Univ., Phamaceutical Engineering"},{"@language":"ja","@value":"岐阜薬科大学製剤学研究室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679487765505","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254730295"}],"foaf:name":[{"@language":"en","@value":"SEKIGAWA Fujio"},{"@language":"ja","@value":"関川 富士夫"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Shin-Etsu Chemical Co., Ltd."},{"@language":"ja","@value":"信越化学工業 (株)"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03866157"},{"@type":"LISSN","@value":"03866157"},{"@type":"EISSN","@value":"18837239"}],"prism:publicationName":[{"@language":"ja","@value":"粉体工学会誌"},{"@language":"en","@value":"Journal of the Society of Powder Technology, Japan"},{"@language":"ja","@value":"粉体工学会誌"},{"@language":"en","@value":"Funtai Kogakkaishi"},{"@language":"en","@value":"J. Soc. Powder Technol., Japan"},{"@language":"en","@value":"J. Soc. Powder Technolo, Japan"},{"@language":"ja","@value":"粉工誌"}],"dc:publisher":[{"@language":"en","@value":"The Society of Powder Technology, Japan"},{"@language":"ja","@value":"一般社団法人 粉体工学会"}],"prism:publicationDate":"1992","prism:volume":"29","prism:number":"6","prism:startingPage":"456","prism:endingPage":"459"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","availableAt":"1992","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Low-substituted%20Hydroxypropylcellulose","dc:title":"Low-substituted Hydroxypropylcellulose"},{"@id":"https://cir.nii.ac.jp/all?q=Flowability","dc:title":"Flowability"},{"@id":"https://cir.nii.ac.jp/all?q=Controlled-release%20Matrix%20Base","dc:title":"Controlled-release Matrix Base"},{"@id":"https://cir.nii.ac.jp/all?q=Swelling%20Force","dc:title":"Swelling Force"},{"@id":"https://cir.nii.ac.jp/all?q=Wet%20Granulation","dc:title":"Wet Granulation"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0007868502"},{"@type":"CROSSREF","@value":"10.4164/sptj.29.456"},{"@type":"CIA","@value":"130003952052"},{"@type":"OPENAIRE","@value":"doi_dedup___::bbd14f4d77791ea390bf2c0f92e4e8e3"}]}