{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679529891712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11251/ojjscn1969.35.327"}},{"identifier":{"@type":"PMID","@value":"12875210"}},{"identifier":{"@type":"NAID","@value":"10011222211"}},{"identifier":{"@type":"NAID","@value":"130004183603"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2003309870"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"High-dose Intravenous Immunoglobulin Therapy in a Child Case of Bickerstaff's Brainstem Encephalitis"},{"@value":"免疫グロブリン大量静注療法が奏効したＢｉｃｋｅｒｓｔａｆｆ型脳幹脳炎の小児例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We report an 11-year-old boy with Bickerstaff's brainstem encephalitis (BBE). He had gait disturbance, disturbed consciousness, and diplopia after upper respiratory tract infection. On admission, he showed multiple cranial nerve palsy, muscle weakness of arms, cerebeller ataxia and generalized areflexia. The cerebrospinal fluid on day 7 revealed albuminocytologic dissociation. IgG antibodies against GQ1b and GT 1 a were detected in the serum. Immunoglobulin was administered intravenously from day 11, and then his symptoms gradually diminished. When he was discharged on day 27, he had neither conscious disturbance nor limb weakness. There still were mild ophthalmoparesis and diminished deep tendon reflexes, but they disappeared by 10 months after the onset.<BR>Effective therapy for BBE has yet to be established. Our case had features of Guillain-Barre syndrome (GBS) and Miller Fisher syndrome, such as an acute monophasic course, limb weakness with areflexia, albuminocytologic dissociation in the cerebrospinal fluid, detection of serum anti-ganglioside antibodies and efficacy of intravenous immunoglobulin, indicating that BBE and GBS are closely related. Our case suggested that intravenous immunoglobulin therapy, an established treatment for GBS, should be considered in some patients with BBE."},{"@value":"症例は11歳男児. 上気道炎症状の後, 歩行障害と意識障害, 眼球運動障害で発症し, 多発性脳神経障害や両上肢の筋力低下, 小脳症状, 深部腱反射の消失を認めた. 第7病日に行った髄液検査で髄液蛋白細胞解離がみられ, 急性期血中にGQ1bとGT1aに対するIgG抗体を検出した. Bickerstaff型脳幹脳炎 (BBE) と診断し, 免疫グロブリン大量静注療法を行った. 投与中に眼球運動障害や嚥下障害, 小脳症状および両上肢の筋力低下は改善傾向を示し, 退院時には軽度の眼球運動障害と深部腱反射の消失を認めるのみとなった.<BR>BBEにおける治療法は確立していない. 本症例では上肢脱力や髄液蛋白細胞解離, 抗ガングリオシド抗体陽性などGuillain-Barre症候群と類似した点が多くみられ, さらにGuillain-Barre症候群で有効性の確立した治療法である免疫グロブリン大量静注療法が奏効した. 免疫グロブリン大量静注療法は, BBEの治療において選択肢のひとつとして考慮すべきである."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410572172007933954","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256119756"},{"@type":"NRID","@value":"9000014394295"}],"foaf:name":[{"@language":"en","@value":"Sugiyama Nobuyoshi"},{"@language":"ja","@value":"杉山 延喜"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Neurology, Saitama Children's Medical Center"},{"@language":"ja","@value":"埼玉県立小児医療センター神経科"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751143629824","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80208595"},{"@type":"NRID","@value":"1000080208595"},{"@type":"NRID","@value":"9000365028798"},{"@type":"NRID","@value":"9000365030047"},{"@type":"NRID","@value":"9000365027384"},{"@type":"NRID","@value":"9000255730441"},{"@type":"NRID","@value":"9000009584354"},{"@type":"NRID","@value":"9000021456362"},{"@type":"NRID","@value":"9000021476151"},{"@type":"NRID","@value":"9000283719712"},{"@type":"NRID","@value":"9000255729933"},{"@type":"NRID","@value":"9000255730164"},{"@type":"NRID","@value":"9000004274413"},{"@type":"NRID","@value":"9000377395475"},{"@type":"NRID","@value":"9000265255290"},{"@type":"NRID","@value":"9000340448171"},{"@type":"NRID","@value":"9000365030365"},{"@type":"NRID","@value":"9000365027249"},{"@type":"NRID","@value":"9000398425943"},{"@type":"NRID","@value":"9000398425940"},{"@type":"NRID","@value":"9000398425937"},{"@type":"NRID","@value":"9000283719700"},{"@type":"NRID","@value":"9000365027555"},{"@type":"NRID","@value":"9000399812232"},{"@type":"NRID","@value":"9000255730424"},{"@type":"NRID","@value":"9000255729652"},{"@type":"NRID","@value":"9000255729388"},{"@type":"NRID","@value":"9000361679159"},{"@type":"NRID","@value":"9000361678875"},{"@type":"NRID","@value":"9000367864502"},{"@type":"NRID","@value":"9000318140226"},{"@type":"NRID","@value":"9000331088882"},{"@type":"NRID","@value":"9000365030361"},{"@type":"NRID","@value":"9000365030035"},{"@type":"NRID","@value":"9000365030198"},{"@type":"NRID","@value":"9000367864616"},{"@type":"NRID","@value":"9000255730646"},{"@type":"NRID","@value":"9000255729684"},{"@type":"NRID","@value":"9000010483000"},{"@type":"NRID","@value":"9000399514757"},{"@type":"NRID","@value":"9000365028404"},{"@type":"NRID","@value":"9000379558217"},{"@type":"NRID","@value":"9000365030411"},{"@type":"NRID","@value":"9000365030168"},{"@type":"NRID","@value":"9000256115327"},{"@type":"NRID","@value":"9000256119023"},{"@type":"NRID","@value":"9000365029074"},{"@type":"NRID","@value":"9000255730490"},{"@type":"NRID","@value":"9000365029854"},{"@type":"NRID","@value":"9000359885222"},{"@type":"NRID","@value":"9000243879521"},{"@type":"NRID","@value":"9000255729447"},{"@type":"NRID","@value":"9000365029436"},{"@type":"NRID","@value":"9000255730455"}],"foaf:name":[{"@language":"en","@value":"Hamano Shinichiro"},{"@language":"ja","@value":"浜野 晋一郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Neurology, Saitama Children's Medical Center"},{"@language":"ja","@value":"埼玉県立小児医療センター神経科"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326233858816","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60383014"},{"@type":"NRID","@value":"1000060383014"},{"@type":"NRID","@value":"9000363350897"},{"@type":"NRID","@value":"9000348631653"},{"@type":"NRID","@value":"9000404494510"},{"@type":"NRID","@value":"9000413888293"},{"@type":"NRID","@value":"9000016873861"},{"@type":"NRID","@value":"9000411811981"},{"@type":"NRID","@value":"9000363359688"},{"@type":"NRID","@value":"9000414527701"},{"@type":"NRID","@value":"9000415413061"},{"@type":"NRID","@value":"9000002060814"},{"@type":"NRID","@value":"9000018484733"},{"@type":"NRID","@value":"9000413250214"},{"@type":"NRID","@value":"9000410045329"},{"@type":"NRID","@value":"9000021937897"},{"@type":"NRID","@value":"9000414224271"},{"@type":"NRID","@value":"9000409180164"},{"@type":"NRID","@value":"9000405895915"},{"@type":"NRID","@value":"9000410045334"},{"@type":"NRID","@value":"9000412410678"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000023552"}],"foaf:name":[{"@language":"en","@value":"Koga Michiaki"},{"@language":"ja","@value":"古賀 道明"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neurology, Dokkyo University School of Medicine"},{"@language":"ja","@value":"獨協医科大学神経内科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00290831"},{"@type":"EISSN","@value":"18847668"},{"@type":"NCID","@value":"AN0020232X"}],"prism:publicationName":[{"@language":"en","@value":"NO TO HATATSU"},{"@language":"ja","@value":"脳と発達"},{"@language":"en","@value":"NO TO HATATSU"},{"@language":"ja","@value":"脳と発達"}],"dc:publisher":[{"@language":"en","@value":"THE JAPANESE SOCIETY OF CHILD NEUROLOGY"}],"prism:publicationDate":"2003","prism:volume":"35","prism:number":"4","prism:startingPage":"327","prism:endingPage":"330"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2003309870"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Bickerstaff%E5%9E%8B%E8%84%B3%E5%B9%B9%E8%84%B3%E7%82%8E","dc:title":"Bickerstaff型脳幹脳炎"},{"@id":"https://cir.nii.ac.jp/all?q=Guillain-Barre%E7%97%87%E5%80%99%E7%BE%A4","dc:title":"Guillain-Barre症候群"},{"@id":"https://cir.nii.ac.jp/all?q=Fisher%E7%97%87%E5%80%99%E7%BE%A4","dc:title":"Fisher症候群"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%8A%97%E3%82%AC%E3%83%B3%E3%82%B0%E3%83%AA%E3%82%AA%E3%82%B7%E3%83%89%E6%8A%97%E4%BD%93","dc:title":"抗ガングリオシド抗体"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%85%8D%E7%96%AB%E3%82%B0%E3%83%AD%E3%83%96%E3%83%AA%E3%83%B3%E5%A4%A7%E9%87%8F%E9%9D%99%E6%B3%A8%E7%99%82%E6%B3%95","dc:title":"免疫グロブリン大量静注療法"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1361699995455306112","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Serum 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Clinical and immunological range"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974779598208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Plasmapheresis and acute Guillain-Barre syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399709730432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"抗 GQ1b, 抗 GT1a, 抗 GM1 抗体が陽性であった Bickerstaff 型脳幹脳炎の1例"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399709732480","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0023028233"},{"@type":"PUBMED","@value":"12875210"},{"@type":"CIA","@value":"130004183603"},{"@type":"CIA","@value":"10011222211"}]}