γ-Selective Addition to 1,1-Difluoroallenes: Three-component Coupling Leading to 2,2-Disubstituted 1,1-Difluoroalkenes

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  • Fuchibe Kohei
    Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba
  • Ueda Mikiko
    Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba
  • Yokota Misaki
    Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba
  • Ichikawa Junji
    Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba

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Abstract

1,1-Difluoroallenes underwent γ-selective addition with alkylcopper reagents. The resulting 2,2-difluorovinylcopper intermediates were captured by electrophiles or subjected to palladium-catalyzed coupling to give 2,2-disubstituted 1,1-difluoroalkenes in good yield.

Journal

  • Chemistry Letters

    Chemistry Letters 41 (12), 1619-1621, 2012

    The Chemical Society of Japan

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