Facile Synthesis of .BETA.,.BETA.-Difluorostyrenes via the Negishi Coupling of Thermally Stable 2,2-Difluorovinyl Zinc-TMEDA Complex
-
- Fujita Takeshi
- Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
-
- Ichitsuka Tomohiro
- Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
-
- Fuchibe Kohei
- Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
-
- Ichikawa Junji
- Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
Bibliographic Information
- Other Title
-
- Facile Synthesis of β,β-Difluorostyrenes via the Negishi Coupling of Thermally Stable 2,2-Difluorovinyl Zinc–TMEDA Complex
Search this article
Abstract
2,2-Difluorovinylzinc chloride–TMEDA complex, readily prepared from 1,1-difluoroethylene, undergoes the palladium-catalyzed coupling reaction with aryl halides to afford β,β-difluorostyrenes in high yield. This reaction not only proceeds smoothly with sterically hindered triflates and halides including chlorides, but also exhibits excellent chemoselectivities for multi-halogenated substrates. The intermediary TMEDA complex was found to be thermally stable and storable.
Journal
-
- Chemistry Letters
-
Chemistry Letters 40 (9), 986-988, 2011
The Chemical Society of Japan
- Tweet
Keywords
Details
-
- CRID
- 1390282679565309568
-
- NII Article ID
- 10029522357
-
- NII Book ID
- AA00603318
-
- ISSN
- 13480715
- 03667022
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed