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Click Reaction Based on the Biosynthesis of Firefly Luciferin

Abstract

<p>Novel click chemistry was developed based on the biosynthetic process of firefly luciferin, which includes an ideal coupling of a cyanothiazole residue with cysteine. Among various biomimetic couplings of nitriles with cysteine derivatives, the approach using 4-cyanopyridine and cysteine methyl ester provided a very rapid and quantitative conversion to the corresponding thiazole without any metal catalyst at room temperature.</p>

Journal

  • Chemistry Letters

    Chemistry Letters 46 (5), 753-755, 2017

    The Chemical Society of Japan

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Details

  • CRID
    1390282679566223232
  • NII Article ID
    130005655715
  • DOI
    10.1246/cl.170094
  • ISSN
    13480715
    03667022
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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