{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679566407808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1246/cl.130419"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BC3sXhsFOktrjN"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/chemlett/article-pdf/42/9/1051/55642747/cl.130419.pdf"}},{"identifier":{"@type":"NAID","@value":"10031194338"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Discovery of Synthetic Methoxy-substituted 4-Phenylbutyric Acid Derivatives as Chemical Chaperones"},{"@value":"Discovery of synthetic methoxysubstituted - phenylbutyric acid derivatives as chemical chaperons"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"In this study, we evaluated the chemical chaperone activity of synthetic 4-phenylbutyric acid (4-PBA) derivatives. These derivatives have a methoxy group at the benzene ring and/or longer or shorter fatty acid portions. Several 4-PBA derivatives demonstrated higher antiaggregation activity than 4-PBA. Moreover, 4-(4-methoxyphenyl)butanoic acid (<b>7b</b>) showed protective effects against endoplasmic reticulum stress-induced neuronal cell death."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679566407812","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000263064459"}],"foaf:name":[{"@language":"en","@value":"Mimori Seisuke"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chiba Institute of 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Yasunobu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751158295552","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10322827"},{"@type":"NRID","@value":"1000010322827"},{"@type":"NRID","@value":"9000314057334"},{"@type":"NRID","@value":"9000021806889"},{"@type":"NRID","@value":"9000408808154"},{"@type":"NRID","@value":"9000021810104"},{"@type":"NRID","@value":"9000406380266"},{"@type":"NRID","@value":"9000263064461"},{"@type":"NRID","@value":"9000412604297"},{"@type":"NRID","@value":"9000321635945"},{"@type":"NRID","@value":"9000365543010"},{"@type":"NRID","@value":"9000411832632"},{"@type":"NRID","@value":"9000257820937"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0103544"}],"foaf:name":[{"@language":"en","@value":"Kaneko Masayuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326208610304","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30581631"},{"@type":"NRID","@value":"1000030581631"},{"@type":"NRID","@value":"9000324992731"},{"@type":"NRID","@value":"9000014154714"},{"@type":"NRID","@value":"9000021810109"},{"@type":"NRID","@value":"9000263064462"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/KWD"}],"foaf:name":[{"@language":"en","@value":"Kawada Koichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of 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