{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679599115648.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.17.1329"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK2MXksVSnurY%3D"}},{"identifier":{"@type":"PMID","@value":"7874052"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb1993/17/10/17_10_1329/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003640424"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1995212866"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Inhibition of Helicobacter pylori Urease Activity by Hydroxamic Acid Derivatives."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Helicobacter pylori (HP) produces strong urease [EC 3.5.1.5], which is considered to play a role in the pathogenesis of gastritis and peptic ulcers. Inhibitions against this enzyme have been studied with hydroxamic acid (HXA) derivatives of aliphatic or aromatic carboxylic acids, amino acids and dipeptides. A number of HXAs potently inhibited the urease (I<SUB>50</SUB> values were near the order of 10<SUP>-6</SUP>M), and H-Ile-Gly-NHOH (I<SUB>50</SUB>=0.20×10<SUP>-6</SUP>M) was the most potent inhibitor among the derivatives. HP urease was inhibited more potently, in general, than Jack bean (JB) urease by HXAs, and a correlation between the chemical structures of HXA derivatives and their inhibitory effects on HP urease was observed, in comparison with JB urease."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679599115650","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020354083"}],"foaf:name":[{"@language":"en","@value":"ODAKE Shinjiro"},{"@language":"ja","@value":"小竹 慎二郎"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679599115651","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020354086"}],"foaf:name":[{"@language":"en","@value":"MORIKAWA Tadanori"},{"@language":"ja","@value":"森川 忠則"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679599115648","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020354092"}],"foaf:name":[{"@language":"en","@value":"TSUCHIYA Mamiko"},{"@language":"ja","@value":"土谷 満美子"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133413491329","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10232620"},{"@type":"NRID","@value":"1000010232620"},{"@type":"NRID","@value":"9000005187571"},{"@type":"NRID","@value":"9000022037975"},{"@type":"NRID","@value":"9000254233953"},{"@type":"NRID","@value":"9000020334600"},{"@type":"NRID","@value":"9000254480202"},{"@type":"NRID","@value":"9000020354095"},{"@type":"NRID","@value":"9000005254888"},{"@type":"NRID","@value":"9000254706354"},{"@type":"NRID","@value":"9000254596337"}],"foaf:name":[{"@language":"en","@value":"IMAMURA Lisa"},{"@language":"ja","@value":"今村 理佐"}]},{"@id":"https://cir.nii.ac.jp/crid/1030566608268487298","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80019108"},{"@type":"NRID","@value":"1000080019108"},{"@type":"NRID","@value":"9000014413745"},{"@type":"NRID","@value":"9000020069418"},{"@type":"NRID","@value":"9000254676942"},{"@type":"NRID","@value":"9000253205108"},{"@type":"NRID","@value":"9000253194937"},{"@type":"NRID","@value":"9000005257050"},{"@type":"NRID","@value":"9000254222015"},{"@type":"NRID","@value":"9000254235167"},{"@type":"NRID","@value":"9000021880848"},{"@type":"NRID","@value":"9000254698518"},{"@type":"NRID","@value":"9000254704411"},{"@type":"NRID","@value":"9000391651294"},{"@type":"NRID","@value":"9000391630164"},{"@type":"NRID","@value":"9000254236108"},{"@type":"NRID","@value":"9000006295294"},{"@type":"NRID","@value":"9000254592992"},{"@type":"NRID","@value":"9000020233650"},{"@type":"NRID","@value":"9000254703852"},{"@type":"NRID","@value":"9000392668221"},{"@type":"NRID","@value":"9000391630607"},{"@type":"NRID","@value":"9000253198103"},{"@type":"NRID","@value":"9000254694022"},{"@type":"NRID","@value":"9000254702489"},{"@type":"NRID","@value":"9000392671828"},{"@type":"NRID","@value":"9000254676149"},{"@type":"NRID","@value":"9000254223194"},{"@type":"NRID","@value":"9000254688079"},{"@type":"NRID","@value":"9000020184866"},{"@type":"NRID","@value":"9000023604748"},{"@type":"NRID","@value":"9000391641951"},{"@type":"NRID","@value":"9000253202245"},{"@type":"NRID","@value":"9000254234299"},{"@type":"NRID","@value":"9000254233954"},{"@type":"NRID","@value":"9000254702170"},{"@type":"NRID","@value":"9000254595733"},{"@type":"NRID","@value":"9000003172993"},{"@type":"NRID","@value":"9000254670788"},{"@type":"NRID","@value":"9000022038336"},{"@type":"NRID","@value":"9000253203570"},{"@type":"NRID","@value":"9000017848131"},{"@type":"NRID","@value":"9000020334609"},{"@type":"NRID","@value":"9000020184251"},{"@type":"NRID","@value":"9000254698028"},{"@type":"NRID","@value":"9000391642976"},{"@type":"NRID","@value":"9000253207604"},{"@type":"NRID","@value":"9000253208258"},{"@type":"NRID","@value":"9000021042332"},{"@type":"NRID","@value":"9000391653737"},{"@type":"NRID","@value":"9000254480203"},{"@type":"NRID","@value":"9000391652645"},{"@type":"NRID","@value":"9000254233661"},{"@type":"NRID","@value":"9000021871925"},{"@type":"NRID","@value":"9000254697594"},{"@type":"NRID","@value":"9000005238382"},{"@type":"NRID","@value":"9000020277527"},{"@type":"NRID","@value":"9000020354099"},{"@type":"NRID","@value":"9000005254890"},{"@type":"NRID","@value":"9000254675933"},{"@type":"NRID","@value":"9000253205368"},{"@type":"NRID","@value":"9000252810735"},{"@type":"NRID","@value":"9000254075729"},{"@type":"NRID","@value":"9000254234254"},{"@type":"NRID","@value":"9000254234273"},{"@type":"NRID","@value":"9000253195661"},{"@type":"NRID","@value":"9000254704405"},{"@type":"NRID","@value":"9000254706358"},{"@type":"NRID","@value":"9000254674412"},{"@type":"NRID","@value":"9000254212884"},{"@type":"NRID","@value":"9000020070313"},{"@type":"NRID","@value":"9000253197505"},{"@type":"NRID","@value":"9000254225793"},{"@type":"NRID","@value":"9000020956015"},{"@type":"NRID","@value":"9000020004863"},{"@type":"NRID","@value":"9000254690028"},{"@type":"NRID","@value":"9000254705818"},{"@type":"NRID","@value":"9000254228364"},{"@type":"NRID","@value":"9000020988155"},{"@type":"NRID","@value":"9000391628557"},{"@type":"NRID","@value":"9000391617229"},{"@type":"NRID","@value":"9000391622656"},{"@type":"NRID","@value":"9000253205364"},{"@type":"NRID","@value":"9000254596339"},{"@type":"NRID","@value":"9000021042963"},{"@type":"NRID","@value":"9000020024736"},{"@type":"NRID","@value":"9000391656203"},{"@type":"NRID","@value":"9000391630618"},{"@type":"NRID","@value":"9000252810662"},{"@type":"NRID","@value":"9000254075901"},{"@type":"NRID","@value":"9000254704336"}],"foaf:name":[{"@language":"en","@value":"KOBASHI Kyoichi"},{"@language":"ja","@value":"小橋 恭一"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/09186158"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1994","prism:volume":"17","prism:number":"10","prism:startingPage":"1329","prism:endingPage":"1332"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/bpb1993/17/10/17_10_1329/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1995212866"}],"availableAt":"1994","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Helicobacter%20pylori%20urease","dc:title":"Helicobacter pylori urease"},{"@id":"https://cir.nii.ac.jp/all?q=inhibition","dc:title":"inhibition"},{"@id":"https://cir.nii.ac.jp/all?q=hydroxamic%20acid","dc:title":"hydroxamic acid"},{"@id":"https://cir.nii.ac.jp/all?q=Jack%20bean%20urease","dc:title":"Jack bean urease"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204626565888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Metabolism of Chiisanoside from Acanthopanax divaricatus var. albeofructus by Human Intestinal Bacteria and Its Relation to Some Biological Activities."},{"@value":"Metabolism of Chiisanoside from Acanthopanax divaricatus var.alveofructus by Human Intestinal Bacteria and Its Relation to Some Biological Activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204627302016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Metabolism of 20(S)- and 20(R)-Ginsenoside Rg3 by Human Intestinal Bacteria and Its Relation to in Vitro Biological Activities."}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008084432"},{"@type":"CROSSREF","@value":"10.1248/bpb.17.1329"},{"@type":"PUBMED","@value":"7874052"},{"@type":"CIA","@value":"110003640424"},{"@type":"CROSSREF","@value":"10.1248/bpb.25.58_references_DOI_8CwQJXhJ3CwSDjaxc5LwJrNcHPc"},{"@type":"CROSSREF","@value":"10.1248/bpb.24.582_references_DOI_8CwQJXhJ3CwSDjaxc5LwJrNcHPc"}]}