{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679599831808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.19.824"}},{"identifier":{"@type":"PMID","@value":"8799480"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb1993/19/6/19_6_824/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003641270"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1996227201"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Differentiation Inducing Effects of 2-Chloro-3-amino-1,4-naphthoquinone on Human Leukemia HL-60."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"There are some highly cytotoxic anticancer compounds inducing differentiation of cancer cells to normal cells at below highly cytotoxic concentration. Naphthoquinone derivatives having cytotoxic effects on cancer cell were tested to learn whether they have differentiation inducing activity in human leukemia HL-60 cells or not. When HL-60 cells were treated with 2-chloro-3-amino-1, 4-naphthoquinone (CANQ) for four days, differentiation-related phenotypes such as nitrobluetetrazolium (NBT)-reducing ability and phagocytosis were induced. These differentiation markers were increased by cotreatment with 1, 25-dihydroxyvitamin D<SUB>3</SUB> which is a well-known inducer of differentiation in HL-60 cells. To evaluate the route of differentiation induced by CANQ, we examined naphthol AS-D chloroacetate esterase and α-naphthylacetate esterase activities and changes in cellular size and granulation. Treatment of HL-60 cells with CANQ for four days resulted in an 82.4% increase in α-naphthylacetate esterase activity in spite of a 0.2% increase in naphthol AS-D chloroacetate esterase activity. The size of cells in cell mass was larger and granulation was more decreased than untreated cells. These results indicate that HL-60 cells were induced to differentiate into macrophage-like cells."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679599831808","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005256309"}],"foaf:name":[{"@language":"en","@value":"BAE Kyong Ah"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679599831809","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005256311"}],"foaf:name":[{"@language":"en","@value":"CHOUNG Se Young"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1996","prism:volume":"19","prism:number":"6","prism:startingPage":"824","prism:endingPage":"827"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/bpb1993/19/6/19_6_824/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1996227201"}],"availableAt":"1996","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=1,%204-naphthoquinone","dc:title":"1, 4-naphthoquinone"},{"@id":"https://cir.nii.ac.jp/all?q=HL-60","dc:title":"HL-60"},{"@id":"https://cir.nii.ac.jp/all?q=differentiation","dc:title":"differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=macrophage","dc:title":"macrophage"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360018298314774272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Identification of a population of bipotent stem cells in the HL60 human promyelocytic leukemia cell line"}]},{"@id":"https://cir.nii.ac.jp/crid/1360862719426385920","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Immune interferon and leukocyte-conditioned medium induce normal and leukemic myeloid cells to differentiate along the monocytic pathway."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471316524160","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943852657664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894081100160","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds."}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749143330688","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570291224561405952","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570854174514830720","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417124468248064","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417124468249088","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417124468251264","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980076615891456","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543026566741248","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572824501529197696","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573387449305225856","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668923841617792","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668924281936128","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950398817372032","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231874071953792","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231874235355264","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231876396399232","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231876409051904","@type":"Article","relationType":["cites"]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008270729"},{"@type":"CROSSREF","@value":"10.1248/bpb.19.824"},{"@type":"PUBMED","@value":"8799480"},{"@type":"CIA","@value":"110003641270"}]}