{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679599997952.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.19.1463"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK28Xnt1Oqurc%3D"}},{"identifier":{"@type":"PMID","@value":"8951165"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"4080089"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/4080089"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I4080089"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb1993/19/11/19_11_1463/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003663348"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1997167627"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Pharmacological Properties of Traditional Medicines. XXII. Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat."},{"@value":"Pharmacological Properties of Traditional Medicines.22.Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat"},{"@language":"ja-Kana","@value":"Pharmacological Properties of Tradition"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"To identify the active components in Mori Cortex (Chinese medicine), Mori Cortex extracts were administered orally to rats, and then blood plasma, urine, and bile were analyzed. The results showed only a few remaining metabolites of mulberroside A. Consequently, to clarify the transitional properties of mulberroside A derivatives to tissues and the in vivo abundance ratio of mulberroside A compounds, the pharmacokinetics of mulberroside A derivatives were investigated in this study. When Mori Cortex extracts were administered orally, mulberroside A was only detected in small quantities in the plasma, and its bioavailability was a bout 1%. This is due to the first pass effect, by which most mulberroside A was converted into oxyresveratrol and transported into the circulating blood, and its absorption ratio was estimated at about 50%. Oxyresvertrol was also found to be transported to tissues at high rates. As a result, when analyzing the pharmacological activity of the Mori Cortex in vitro, it is more useful to study oxyresveratarol than mulberroside A."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204162406789","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005139206"}],"foaf:name":[{"@language":"en","@value":"QIU Feng"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133298762112","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30162043"},{"@type":"NRID","@value":"1000030162043"},{"@type":"NRID","@value":"9000003154880"},{"@type":"NRID","@value":"9000020647057"},{"@type":"NRID","@value":"9000005126695"},{"@type":"NRID","@value":"9000254234172"},{"@type":"NRID","@value":"9000021863688"},{"@type":"NRID","@value":"9000254703814"},{"@type":"NRID","@value":"9000254232860"},{"@type":"NRID","@value":"9000020280075"},{"@type":"NRID","@value":"9000020784027"},{"@type":"NRID","@value":"9000254850391"},{"@type":"NRID","@value":"9000020789625"},{"@type":"NRID","@value":"9000318137720"},{"@type":"NRID","@value":"9000252934137"},{"@type":"NRID","@value":"9000256583360"},{"@type":"NRID","@value":"9000403265031"},{"@type":"NRID","@value":"9000254699916"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0021917"}],"foaf:name":[{"@language":"en","@value":"KOMATSU Ken-ichi"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679599997954","@type":"Researcher","foaf:name":[{"@language":"en","@value":"SAITO Ken-ichi"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679599997957","@type":"Researcher","foaf:name":[{"@language":"en","@value":"KAWASAKI Kanako"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679599997953","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005286185"}],"foaf:name":[{"@language":"en","@value":"YAO Xinsheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204626978306","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005237125"}],"foaf:name":[{"@language":"en","@value":"KANO Yoshihiro"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NDL_BIB_ID","@value":"000000153250"},{"@type":"ISSN","@value":"09186158"},{"@type":"LISSN","@value":"09186158"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1996","prism:volume":"19","prism:number":"11","prism:startingPage":"1463","prism:endingPage":"1467"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/4080089"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I4080089"},{"@id":"http://www.jstage.jst.go.jp/article/bpb1993/19/11/19_11_1463/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1997167627"}],"availableAt":"1996","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=mulberroside%20A","dc:title":"mulberroside A"},{"@id":"https://cir.nii.ac.jp/all?q=oxyresveratrol","dc:title":"oxyresveratrol"},{"@id":"https://cir.nii.ac.jp/all?q=metabolite","dc:title":"metabolite"},{"@id":"https://cir.nii.ac.jp/all?q=Mori%20Cortex","dc:title":"Mori Cortex"},{"@id":"https://cir.nii.ac.jp/all?q=pharmacokinetic","dc:title":"pharmacokinetic"},{"@id":"https://cir.nii.ac.jp/all?q=HPLC","dc:title":"HPLC"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1364233270481661824","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Two Phenolic Glycosides from the Root Bark of the Cultivated Mulberry Tree (Morus lhou)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204158553984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the chinese traditional medicine, \"Goshuyu-to\" and component crude drugs."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206479506176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enhancement of the Tyrosinase Inhibitory Activity of Mori Cortex Radicis Extract by Biotransformation Using <i>Leuconostoc paramesenteroides</i> PR"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679149201792","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Efficient Synthesis of Natural Polyphenolic Stilbenes: Resveratrol, Piceatannol and Oxyresveratrol"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679599560704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pharmacological Properties of Traditional Medicines. XXIII. Searching for Active Compounds in the Blood and Bile of Rats after Oral Administrations of Extracts of Sansohnin."},{"@value":"Pharmacological Properties of Traditional Medicines 23.Searching for Active Compounds in the Blood and Bile of Rats after Oral Administrations of Extracts of Sansohnin(酸棗仁)"},{"@language":"ja-Kana","@value":"Pharmacological Properties of Tradition"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679599593216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pharmacological Properties of Galenical Preparation. XVI. Pharmacokinetics of Evodiamine and the Metabolite in Rats."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680155021952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regioselective Glucuronidation of Oxyresveratrol, a Natural Hydroxystilbene, by Human Liver and Intestinal Microsomes and Recombinant UGTs"}]},{"@id":"https://cir.nii.ac.jp/crid/1520853832512754432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Pharmacological Properties of Traditional Medicines(21)Analysis of Plasma,Urine and Bile of Rats after Oral Administration of Water Extract of Mori Cortex"},{"@language":"ja-Kana","@value":"Pharmacological Properties of Tradition"},{"@language":"en","@value":"Pharmacological Properties of Traditional Medicines (XXI) : Analysis of Plasma, Urine and Bile of Rats after Oral Administration of Water Extract of Mori Cortex :"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749584620800","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980074421595392","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572261549398305152","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543024325779200","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543024375015680","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572824499351729152","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668924281861760","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231874235282176","@type":"Article","relationType":["cites"]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008319188"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I4080089"},{"@type":"CROSSREF","@value":"10.1248/bpb.19.1463"},{"@type":"PUBMED","@value":"8951165"},{"@type":"CIA","@value":"110003663348"},{"@type":"CROSSREF","@value":"10.1248/cpb.58.1492_references_DOI_Wsvy88RIisuGZ1VdAE0fjaOqB3"},{"@type":"CROSSREF","@value":"10.1271/bbb.111002_references_DOI_Wsvy88RIisuGZ1VdAE0fjaOqB3"},{"@type":"CROSSREF","@value":"10.2133/dmpk.dmpk-13-rg-102_references_DOI_Wsvy88RIisuGZ1VdAE0fjaOqB3"}]}