{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679601201408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.29.933"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"7892388"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/7892388"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I7892388"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb/29/5/29_5_933/_pdf"}},{"identifier":{"@type":"NAID","@value":"110005602217"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2006296919"}}],"dc:title":[{"@language":"en","@value":"Effects of L/N-Type Calcium Channel Antagonist, Cilnidipine on Progressive Renal Injuries in Dahl Salt-Sensitive Rats"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The sympathetic nerve activity plays an important role on the renal function through the vasoactive system and the renin-angiotensin system. Although interest in the renal protective effects of anti-sympathetic agents has been increased, there are not enough data to clarify this efficiency. Therefore, we investigated the effects of L/N-type calcium channel antagonist, cilnidipine on progressive renal injury in Dahl salt-sensitive (Dahl S) rats. Male Dahl S rats (6 weeks of age) were fed a high salt (4% NaCl) diet. They were divided into groups with similar blood pressure at 12 weeks of age and they received vehicle (<i>n</i>=7) or cilnidipine (30 mg/kg/d as food admix, <i>n</i>=9) for 8 weeks. Cilnidipine treatment suppressed the increase in systolic blood pressure. Although urinary protein excretion was not influenced, cilnidipine inhibited the increase in blood urea nitrogen and decrease in creatinine clearance. Histological investigation revealed that progression of gromerular sclerosis was inhibited in cilnidipine treatment group. Of notes, cilnidipine reduced plasma norepinephrine level and plasma rennin activity compared with vehicle-treated Dahl S rats. These data indicated that cilnidipine has suppressive effects against progressive renal injury in Dahl S rats. This effect is not only explained by the L-type calcium channel blocking action that lowered blood pressure, but also partially explained by the N-type calcium channel blocking action that lead to suppression of the sympathetic nerve activity and renin-angiotensin system."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204626160643","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005129514"}],"foaf:name":[{"@language":"en","@value":"Konda Tomoyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmaceutical Research Laboratories, Ajinomoto Co., Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204626160642","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005129518"}],"foaf:name":[{"@language":"en","@value":"Enomoto Azusa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmaceutical Research Laboratories, Ajinomoto Co., Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326236023552","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80377481"},{"@type":"NRID","@value":"1000080377481"},{"@type":"NRID","@value":"9000317155025"},{"@type":"NRID","@value":"9000257961665"},{"@type":"NRID","@value":"9000010955056"},{"@type":"NRID","@value":"9000003891349"},{"@type":"NRID","@value":"9000380977861"},{"@type":"NRID","@value":"9000414220783"},{"@type":"NRID","@value":"9000411832760"},{"@type":"NRID","@value":"9000021175710"},{"@type":"NRID","@value":"9000411832752"},{"@type":"NRID","@value":"9000003886649"},{"@type":"NRID","@value":"9000021100562"},{"@type":"NRID","@value":"9000408482800"},{"@type":"NRID","@value":"9000005129510"},{"@type":"NRID","@value":"9000238829704"},{"@type":"NRID","@value":"9000412195160"},{"@type":"NRID","@value":"9000410162145"},{"@type":"NRID","@value":"9000367826350"},{"@type":"NRID","@value":"9000259298899"},{"@type":"NRID","@value":"9000410155527"},{"@type":"NRID","@value":"9000392000599"},{"@type":"NRID","@value":"9000257777326"},{"@type":"NRID","@value":"9000020799038"},{"@type":"NRID","@value":"9000242073953"},{"@type":"NRID","@value":"9000408488058"},{"@type":"NRID","@value":"9000411832731"},{"@type":"NRID","@value":"9000004037968"},{"@type":"NRID","@value":"9000414221484"},{"@type":"NRID","@value":"9000256006576"},{"@type":"NRID","@value":"9000257892665"},{"@type":"NRID","@value":"9000022138022"},{"@type":"NRID","@value":"9000410163214"},{"@type":"NRID","@value":"9000408488998"},{"@type":"NRID","@value":"9000259832797"},{"@type":"NRID","@value":"9000261667900"},{"@type":"NRID","@value":"9000021111079"},{"@type":"NRID","@value":"9000021071853"},{"@type":"NRID","@value":"9000014200362"},{"@type":"NRID","@value":"9000240037582"},{"@type":"NRID","@value":"9000398625826"},{"@type":"NRID","@value":"9000413254064"},{"@type":"NRID","@value":"9000408482757"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0119808"}],"foaf:name":[{"@language":"en","@value":"Takahara Akira"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmaceutical Research Laboratories, Ajinomoto Co., Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601201411","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006246161"}],"foaf:name":[{"@language":"en","@value":"Yamamoto Hiroshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmaceutical Research Laboratories, Ajinomoto Co., Inc."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NDL_BIB_ID","@value":"000000153250"},{"@type":"ISSN","@value":"09186158"},{"@type":"LISSN","@value":"09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2006","prism:volume":"29","prism:number":"5","prism:startingPage":"933","prism:endingPage":"937"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/7892388"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I7892388"},{"@id":"http://www.jstage.jst.go.jp/article/bpb/29/5/29_5_933/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2006296919"}],"availableAt":"2006","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=N-type%20calcium%20channel","dc:title":"N-type calcium channel"},{"@id":"https://cir.nii.ac.jp/all?q=hypertension","dc:title":"hypertension"},{"@id":"https://cir.nii.ac.jp/all?q=renal%20disease","dc:title":"renal disease"},{"@id":"https://cir.nii.ac.jp/all?q=Dahl%20salt-sensitive%20(Dahl%20S)%20rat","dc:title":"Dahl salt-sensitive (Dahl S) rat"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050013397240361344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Calcium channel blocker in patients with chronic kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143593170176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145136700928","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Chronic renal denervation prevents glomerular hyperfiltration in diabetic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145748805248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sympathetic-adrenal medullary responses to acute stress in dahl hypertensive (S/JR) 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