{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679601484544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.29.1068"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"7892831"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/7892831"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I7892831"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb/29/5/29_5_1068/_pdf"}},{"identifier":{"@type":"PMID","@value":"16651750"}},{"identifier":{"@type":"NAID","@value":"110005602245"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2006296946"}}],"dc:title":[{"@language":"en","@value":"Comparison of Nicotine Pharmacokinetics in Healthy Japanese Male Smokers Following Application of the Transdermal Nicotine Patch and Cigarette Smoking"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Transdermal nicotine patch (TNP) contains approximately 16.6 and 24.9 mg of nicotine per 20 and 30 cm<sup>2</sup> (TNP-20 and TNP-30). The aims of the study are to investigate linearity of nicotine pharmacokinetics after single application of different strengths of TNP and to directly compare plasma nicotine concentrations with those during cigarette smoking. Twelve healthy Japanese male smokers were randomly allocated to 1 of 2 cohorts consisting of 6 subjects each. Cohort 1 subjects received 1 sheet of TNP-20 (TNP-20×1) in period 1, and 2 sheets of TNP-20 (TNP-20×2) in period 3. Cohort 2 subjects were received 1 sheet of TNP-30 (TNP-30×1) in period 2, and smoked a total of 12 cigarettes at 1 h intervals in period 4. Each TNP was applied to the upper arm for 16 h. After TNP-20×1 or TNP-20×2 treatment in cohort 1, the amount of nicotine delivered from TNP (Dose) was proportional to surface area of TNP. <i>C</i><sub>max</sub> and <i>AUC</i> of nicotine increased with the surface area (Dose), and <i>t</i><sub>max</sub>, <i>t</i><sub>1/2</sub>, <i>CL</i>/<i>F</i> and percentage of dose excreted in urine were almost the same between both treatments. These suggest the linear pharmacokinetics of nicotine in proportion to the surface area and Dose following single application of TNP in identical subjects. In cohort 2, the plasma nicotine concentrations after TNP-30×1 treatment were approximately half those just before each smoking."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679601484546","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006246613"}],"foaf:name":[{"@language":"en","@value":"Sobue Satoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, Pfizer Global R&D, Tokyo Laboratories, Pfizer Japan Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601484544","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006246616"}],"foaf:name":[{"@language":"en","@value":"Sekiguchi Kaneo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, Pfizer Global R&D, Tokyo Laboratories, Pfizer Japan Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601484548","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006246620"}],"foaf:name":[{"@language":"en","@value":"Kikkawa Hironori"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, Pfizer Global R&D, Tokyo Laboratories, Pfizer Japan Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601484547","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006246622"}],"foaf:name":[{"@language":"en","@value":"Akasaki Moriaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Consumer Healthcare Division, Pfizer Japan Inc."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601484545","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006246624"}],"foaf:name":[{"@language":"en","@value":"Irie Shin"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kyushu Clinical Pharmacology Research Clinic, Medical Co. LTA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NDL_BIB_ID","@value":"000000153250"},{"@type":"ISSN","@value":"09186158"},{"@type":"LISSN","@value":"09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2006","prism:volume":"29","prism:number":"5","prism:startingPage":"1068","prism:endingPage":"1073"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/7892831"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I7892831"},{"@id":"http://www.jstage.jst.go.jp/article/bpb/29/5/29_5_1068/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2006296946"}],"availableAt":"2006","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=nicotine","dc:title":"nicotine"},{"@id":"https://cir.nii.ac.jp/all?q=transdermal","dc:title":"transdermal"},{"@id":"https://cir.nii.ac.jp/all?q=pharmacokinetics","dc:title":"pharmacokinetics"},{"@id":"https://cir.nii.ac.jp/all?q=cigarette%20smoking","dc:title":"cigarette smoking"},{"@id":"https://cir.nii.ac.jp/all?q=linearity","dc:title":"linearity"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144325347584","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Differences in Drug Pharmacokinetics Between East Asians and Caucasians and the Role of Genetic Polymorphisms"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618709217152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Nicotine Inhaler"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095086579200","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Effect of Application Sites and Multiple Doses on Nicotine Pharmacokinetics in Healthy Male Japanese Smokers Following Application of the Transdermal Nicotine Patch"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096165526528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arteriovenous 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