{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679601632512.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.22.745"}},{"identifier":{"@type":"PMID","@value":"10443477"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"4802017"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/4802017"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I4802017"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb1993/22/7/22_7_745/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003639751"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2000002001"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"cAMP-Independent Chloride Secretion Activated by a Vasoactive Intestinal Peptide in a Monolayer Culture of Human Bronchial Epithelial Cells."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"To investigate the effects of vasoactive intestinal peptide (VIP) on Cl<SUP>-</SUP> transport across normal human bronchial epithelial (NHBE) cells grown in a monolayer, changes in short-circuit current (Isc) were measured in Ussing chamber systems. In the presence of 10<SUP>-4</SUP>M amiloride, the addition of VIP to the serosal solution led to an increase in the Isc in a concentration-dependent manner, the 50% effective concentration (EC<SUB>50</SUB>) being 2.6×10<SUP>-11</SUP>M. However, the addition of 10<SUP>-5</SUP>M forskolin had little effect on the increase in Isc. On the other hand, in the intracellular cAMP measurement, 10<SUP>-5</SUP>M forskolin remarkably increased the cAMP levels, but 10<SUP>-7</SUP>M VIP did not.This result suggests that Cl<SUP>-</SUP> secretion by VIP is not related to the raised intracellular cAMP levels in NHBE cells."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679601632513","@type":"Researcher","foaf:name":[{"@language":"en","@value":"TOKUNAGA Tetsuhiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601632515","@type":"Researcher","foaf:name":[{"@language":"en","@value":"KISO Tatsuya"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679601632514","@type":"Researcher","foaf:name":[{"@language":"en","@value":"NAMIKAWA Tomoko"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326214712448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90257973"},{"@type":"NRID","@value":"1000090257973"},{"@type":"NRID","@value":"9000018677363"},{"@type":"NRID","@value":"9000006348204"},{"@type":"NRID","@value":"9000391810932"},{"@type":"NRID","@value":"9000392524571"},{"@type":"NRID","@value":"9000002955784"},{"@type":"NRID","@value":"9000399229425"},{"@type":"NRID","@value":"9000392524615"},{"@type":"NRID","@value":"9000258430160"},{"@type":"NRID","@value":"9000391807885"},{"@type":"NRID","@value":"9000375890507"},{"@type":"NRID","@value":"9000005126908"},{"@type":"NRID","@value":"9000303645265"},{"@type":"NRID","@value":"9000305621632"},{"@type":"NRID","@value":"9000378103917"},{"@type":"NRID","@value":"9000375892183"},{"@type":"NRID","@value":"9000375890504"},{"@type":"NRID","@value":"9000405883048"},{"@type":"NRID","@value":"9000405883045"},{"@type":"NRID","@value":"9000398985047"},{"@type":"NRID","@value":"9000405883010"},{"@type":"NRID","@value":"9000253015737"},{"@type":"NRID","@value":"9000402295175"},{"@type":"NRID","@value":"9000308052260"},{"@type":"NRID","@value":"9000414822535"},{"@type":"NRID","@value":"9000405882827"},{"@type":"NRID","@value":"9000304976702"},{"@type":"NRID","@value":"9000308051598"},{"@type":"NRID","@value":"9000414824628"},{"@type":"NRID","@value":"9000392752763"},{"@type":"NRID","@value":"9000392524659"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0181538"}],"foaf:name":[{"@language":"en","@value":"OHTSUBO Yoshikazu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NDL_BIB_ID","@value":"000000153250"},{"@type":"ISSN","@value":"09186158"},{"@type":"LISSN","@value":"09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"1999","prism:volume":"22","prism:number":"7","prism:startingPage":"745","prism:endingPage":"748"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/4802017"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I4802017"},{"@id":"http://www.jstage.jst.go.jp/article/bpb1993/22/7/22_7_745/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2000002001"}],"availableAt":"1999","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=vasoactive%20intestinal%20peptide","dc:title":"vasoactive intestinal peptide"},{"@id":"https://cir.nii.ac.jp/all?q=chloride%20secretion","dc:title":"chloride secretion"},{"@id":"https://cir.nii.ac.jp/all?q=short-circuit%20current%20(Isc)","dc:title":"short-circuit current (Isc)"},{"@id":"https://cir.nii.ac.jp/all?q=transpithelial%20resistance","dc:title":"transpithelial resistance"},{"@id":"https://cir.nii.ac.jp/all?q=cell%20monolayer","dc:title":"cell monolayer"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360574096058888448","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Morphogenesis of the Polarized Epithelial Cell Phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1360581244947281152","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Chloride and sodium transport across bovine tracheal epithelium: Effects of secretagogues and indomethacin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520509917696","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749533600000","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570009749533601152","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570009749533602304","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570009750907433088","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570009751747771904","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570009751769536512","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570291224510310656","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570291224510311936","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570572701689367552","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417124417154688","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417124417155712","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417126616051072","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571980076388634368","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572261549347286784","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543024323997568","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573387449254130304","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668923839543680","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950399207549824","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950399207551104","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950401413702272","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231874184260096","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231874184261248","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231876417774080","@type":"Article","relationType":["cites"]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008643935"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I4802017"},{"@type":"CROSSREF","@value":"10.1248/bpb.22.745"},{"@type":"PUBMED","@value":"10443477"},{"@type":"CIA","@value":"110003639751"}]}