{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679603855744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.27.1147"}},{"identifier":{"@type":"PMID","@value":"15256759"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6986971"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6986971"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6986971"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb/27/7/27_7_1147/_pdf"}},{"identifier":{"@type":"NAID","@value":"110003608932"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2005231990"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Lignans from the Bark of Machilus thunbergii and Their DNA Topoisomerases I and II Inhibition and Cytotoxicity"},{"@value":"Lignans from the Bark of Machilus thunbergii and Their DNA Topoisomerases 1 and 2 Inhibition and Cytotoxicity"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Activity-guided fractionation based on topoisomerase I inhibitory activity lead to the isolation of ten lignans (1—10) from the methylene chloride extract of the bark of <i>Machilus thunbergii</i> S<small>IEB</small>. <i>et</i> Z<small>UCC</small>. (Lauraceae). These were identified as machilin A (1), <i>erythro</i>-austrobailignan-6 (2), <i>meso</i>-monomethyl dihydroguaiaretic acid (3), <i>meso</i>-dihydroguaiaretic acid (4), galbacin (5), machilin F (6), nectandrin A (7) nectandrin B (8), (−)-acuminatin (9) and (7<i>S</i>,8<i>S</i>)-7-(4-hydroxy-3-methoxyphenyl)-1′-formyl-3′-methoxy-8-methyldihydrobenzofuran (10) by spectral evidence. In DNA topoisomerase I and II assays <i>in vitro</i> at a concentration of 100 μ<small>M</small>, 4 showed the most potent inhibitory activity, 93.6 and 82.1% inhibition, respectively, and 8 showed 79.1 and 34.3% inhibition, respectively. All of these compounds exhibited weak or no cytotoxicities against either the human colon carcinoma cell line (HT-29) or the human breast carcinoma cell line (MCF-7)."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204163570054","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005122295"}],"foaf:name":[{"@language":"en","@value":"Li Gao"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Yeungnam University"},{"@language":"en","@value":"College of Pharmacy, Yanbian University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204163570055","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005128661"}],"foaf:name":[{"@language":"en","@value":"Lee Chong-Soon"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biochemistry, College of Science, Yeungnam University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204163570051","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005128665"}],"foaf:name":[{"@language":"en","@value":"Woo Mi-Hee"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Catholic University of Daegu"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679603855748","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Lee Seung-Ho"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Yeungnam University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679603855747","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Chang Hyeun-Wook"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Yeungnam University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679603855745","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Son Jong-Keun"}],"jpcoar:affiliationName":[{"@language":"en","@value":"College of Pharmacy, Yeungnam University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NDL_BIB_ID","@value":"000000153250"},{"@type":"ISSN","@value":"09186158"},{"@type":"LISSN","@value":"09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2004","prism:volume":"27","prism:number":"7","prism:startingPage":"1147","prism:endingPage":"1150"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/6986971"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6986971"},{"@id":"http://www.jstage.jst.go.jp/article/bpb/27/7/27_7_1147/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2005231990"}],"availableAt":"2004","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EMachilus%20thunbergii%3C/i%3E","dc:title":"<i>Machilus thunbergii</i>"},{"@id":"https://cir.nii.ac.jp/all?q=Lauraceae","dc:title":"Lauraceae"},{"@id":"https://cir.nii.ac.jp/all?q=lignan","dc:title":"lignan"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20topoisomerase%20I%20inhibition","dc:title":"DNA topoisomerase I inhibition"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20topoisomerase%20II%20inhibition","dc:title":"DNA topoisomerase II inhibition"},{"@id":"https://cir.nii.ac.jp/all?q=cytotoxicity","dc:title":"cytotoxicity"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285708106733312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neolignans from the Arils of <i>Myristica fragrans</i> as Potent Antagonists of CC Chemokine Receptor 3"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617911571200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618847411072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A butanolide and phenolics from Machilus thunbergii"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619259153024","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Butanolides from <i>Machilus thunbergii</i> and their inhibitory activity on nitric oxide synthesis in activated macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619575498368","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Natural occurrence of Erdtman's dehydrodiisoeugenol"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619633750656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"O-demethylation of meso-dimethyl dihydroguaiaretic acid in spodoptera litura"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619789117952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant Lignans from <i>Machilus thunbergii</i> Protect CCl4-injured Primary Cultures of Rat Hepatocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094550575232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA Topoisomerases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360581243381468800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Phytosterols of the trunks of Lindera obtusiloba"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519314464256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lignans from machilus thunbergii"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519644662144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antiproliferative, Anti-Aromatase, Anti-17β-HSD and Antioxidant Activities of Lignans Isolated from<i>Myristica argentea</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520292049280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"2,3-Dihydrobenzofuran neolignans from Aristolochia pubescens"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993605500160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The chemical constituents of\n                    <i>Himantandra</i>\n                    species. 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