{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679609332736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1046/j.1440-1592.2001.00214.x"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1323893015313575?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1323893015313575?httpAccept=text/xml"}},{"identifier":{"@type":"NAID","@value":"10009585753"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2002014764"}}],"dc:title":[{"@language":"en","@value":"Low-dose exogenous interleukin (IL)-12 enhances antigen-induced interferon-.GAMMA. production without affecting IL-10 production in asthmatics."},{"@value":"Low-Dose Exogenous Interleukin (IL)-12 Enhances Antigen-Induced Interferon-γ Production Without Affecting IL-10 Production in Asthmatics"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<b>Background:</b> Although interleukin (IL)-12, IL-10 and interferon (IFN)-γ are key cytokines that control the T helper (Th) 1/Th2 balance in human allergic disorders, details of their interactions in humans have not been clarified. Recently IL-10, one of the Th2 cytokines, has been shown to have an anti-inflammatory effect against allergic responses. To clarify the effect of IL-12 on the production of IFN-γ and IL-10, in the present study we examined responses of peripheral blood mononuclear cells (PBMC) from asthmatics to stimulation by <i>Dermatophagoides farinae</i> (Df) antigen in the presence of exogenous IL-12.<br> <b>Methods:</b> Peripheral blood mononuclear cells of Df-sensitized (<i>n</i> = 7) and non-sensitized (<i>n</i> = 5) asthmatics were stimulated by Df antigen after incubation with exogenous IL-12 (100 pg/mL). Interferon-γ and IL-10 produced in culture supernatants were measured by ELISA. The effect of IL-12 on lymphocyte proliferation was assayed by [<sup>3</sup>H]-thymidine incorporation in both groups.<br> <b>Results:</b> The production of IFN-γ by PBMC was significantly enhanced by incubation with IL-12 in both patient groups (<i>P</i> < 0.05), while IL-12 did not affect the production of IL-10 in either group. Lymphocyte proliferation induced by Df antigen was significantly higher in the Df-sensitized group (<i>P</i> < 0.01). This lymphocyte proliferation was significantly enhanced by exogenous IL-12 only in the Df-sensitized group (<i>P</i> < 0.05).<br> <b>Conclusions:</b> These observations indicate that IL-12 enhances Th1-shifted immune responses without affecting IL-10 production and suggest that IL-12 may effectively inhibit the Th2 dominant state of bronchial asthma by regulating the Th1/Th2 balance.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679609332744","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Horiba Masahide"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Okayama University Medical School"},{"@language":"en","@value":"Department of Allergy, Minami-Okayama Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679608948232","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000481008"}],"foaf:name":[{"@language":"en","@value":"Kimura Goro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Allergy, Minami-Okayama Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658432052481","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60284098"},{"@type":"NRID","@value":"1000060284098"},{"@type":"NRID","@value":"9000253626406"},{"@type":"NRID","@value":"9000004442074"},{"@type":"NRID","@value":"9000250172783"},{"@type":"NRID","@value":"9000256314150"},{"@type":"NRID","@value":"9000256519051"},{"@type":"NRID","@value":"9000258061561"},{"@type":"NRID","@value":"9000020336566"},{"@type":"NRID","@value":"9000257947353"},{"@type":"NRID","@value":"9000255792047"},{"@type":"NRID","@value":"9000257947338"},{"@type":"NRID","@value":"9000391592783"},{"@type":"NRID","@value":"9000258061927"},{"@type":"NRID","@value":"9000261024271"},{"@type":"NRID","@value":"9000021327770"},{"@type":"NRID","@value":"9000317154993"},{"@type":"NRID","@value":"9000257802155"},{"@type":"NRID","@value":"9000003746471"},{"@type":"NRID","@value":"9000391595563"},{"@type":"NRID","@value":"9000256313649"},{"@type":"NRID","@value":"9000253619345"},{"@type":"NRID","@value":"9000003765735"},{"@type":"NRID","@value":"9000018209852"},{"@type":"NRID","@value":"9000256313907"},{"@type":"NRID","@value":"9000001400399"},{"@type":"NRID","@value":"9000256313763"},{"@type":"NRID","@value":"9000256519661"},{"@type":"NRID","@value":"9000018375521"},{"@type":"NRID","@value":"9000391595747"},{"@type":"NRID","@value":"9000258061748"},{"@type":"NRID","@value":"9000256313979"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0051771"}],"foaf:name":[{"@language":"en","@value":"Tanimoto Yasushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Okayama University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204633198473","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000404667973"},{"@type":"NRID","@value":"9000020591436"},{"@type":"NRID","@value":"9000257947343"},{"@type":"NRID","@value":"9000391593444"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0015886"}],"foaf:name":[{"@language":"en","@value":"Kanehiro Arihiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Okayama University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679609332736","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Takeda Akiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Okayama University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679159793024","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254132963"},{"@type":"NRID","@value":"9000401842118"},{"@type":"NRID","@value":"9000003293382"},{"@type":"NRID","@value":"9000401582370"},{"@type":"NRID","@value":"9000254554157"},{"@type":"NRID","@value":"9000401847355"},{"@type":"NRID","@value":"9000252943718"}],"foaf:name":[{"@language":"en","@value":"Okada Chiharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Allergy, Minami-Okayama Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658432052480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50177391"},{"@type":"NRID","@value":"1000050177391"},{"@type":"NRID","@value":"9000004445315"},{"@type":"NRID","@value":"9000024802413"},{"@type":"NRID","@value":"9000244881534"},{"@type":"NRID","@value":"9000240023819"},{"@type":"NRID","@value":"9000256313895"},{"@type":"NRID","@value":"9000022451013"},{"@type":"NRID","@value":"9000024817472"},{"@type":"NRID","@value":"9000021303173"},{"@type":"NRID","@value":"9000256314145"},{"@type":"NRID","@value":"9000237829557"},{"@type":"NRID","@value":"9000020336562"},{"@type":"NRID","@value":"9000391601535"},{"@type":"NRID","@value":"9000257947336"},{"@type":"NRID","@value":"9000327437877"},{"@type":"NRID","@value":"9000256313644"},{"@type":"NRID","@value":"9000256313954"},{"@type":"NRID","@value":"9000256313912"},{"@type":"NRID","@value":"9000256313760"},{"@type":"NRID","@value":"9000391601537"},{"@type":"NRID","@value":"9000000381853"},{"@type":"NRID","@value":"9000256313975"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0015883"}],"foaf:name":[{"@language":"en","@value":"Kataoka Mikio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Okayama University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679609332742","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Takahashi Kiyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Allergy, Minami-Okayama Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679609332743","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Harada Mine"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Second Department of Internal Medicine, Okayama University Medical School"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13238930"},{"@type":"LISSN","@value":"13238930"},{"@type":"EISSN","@value":"14401592"},{"@type":"NCID","@value":"AA11091750"}],"prism:publicationName":[{"@language":"en","@value":"Allergology International"},{"@language":"en","@value":"Allergol. Int."}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Allergology"},{"@language":"ja","@value":"一般社団法人日本アレルギー学会"}],"prism:publicationDate":"2001","prism:volume":"50","prism:number":"2","prism:startingPage":"143","prism:endingPage":"151"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://api.elsevier.com/content/article/PII:S1323893015313575?httpAccept=text/plain"},{"@id":"https://api.elsevier.com/content/article/PII:S1323893015313575?httpAccept=text/xml"},{"@id":"https://search.jamas.or.jp/link/ui/2002014764"}],"availableAt":"2001","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=bronchial%20asthma","dc:title":"bronchial asthma"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EDermatophagoides%20farinae%3C/i%3E","dc:title":"<i>Dermatophagoides farinae</i>"},{"@id":"https://cir.nii.ac.jp/all?q=interferon-%CE%B3","dc:title":"interferon-γ"},{"@id":"https://cir.nii.ac.jp/all?q=interleukin-10","dc:title":"interleukin-10"},{"@id":"https://cir.nii.ac.jp/all?q=interleukin-12","dc:title":"interleukin-12"},{"@id":"https://cir.nii.ac.jp/all?q=peripheral%20blood%20mononuclear%20cells","dc:title":"peripheral blood mononuclear cells"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360016870027536512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-proliferative effect of IFN-gamma in immune regulation. 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IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones."}]},{"@id":"https://cir.nii.ac.jp/crid/1360016870540252288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619836761728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Statement on Standards for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619859202176","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Interleukin-10 regulation in normal subjects and patients with asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298341431582848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 produced by antigen-presenting cells induces IL-2-independent proliferation of T helper cell clones"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345420005504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 inhibits Th2 cytokine responses induced by eggs of\n                    <i>Schistosoma mansoni</i>\n                    ."}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345420100992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345420282880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 induces human T cells secreting IL-10 with IFN-γ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345420556544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Resistance to Antigen-Induced Airway Hyperresponsiveness Requires Endogenous Production of IL-12"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345516575488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 receptor. 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Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345516818432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of IL-12 on helper T cell-dependent immune responses in vivo."}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345516941824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity."}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345517251584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345517409152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Corticosteroids Enhance the Capacity of Macrophages to Induce Th2 Cytokine Synthesis in CD4+ Lymphocytes by Inhibiting IL-12 Production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094185732480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor by T Cells of Patients with Bronchial Asthma in Response to\n                    <i>Dermatophagoides farinae</i>\n                    and Its Relation to Eosinophil Colony-stimulating Factor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579816408985472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 receptor. 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Distribution and regulation of receptor expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579816409199232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lack of IL-12 signaling in human allergen-specific Th2 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569659689088","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571115825408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1360857671203371904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861291383605632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants."}]},{"@id":"https://cir.nii.ac.jp/crid/1360861291383985408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861291384054400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IL-12 augments antigen-dependent proliferation of activated T lymphocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861291384085120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044333213952","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046024239104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recombinant human interleukin 5 is a selective activator of human eosinophil function."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519528937728","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519974660352","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520122406016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhaled Corticosteroids Increase Interleukin-10 but Reduce Macrophage Inflammatory Protein-1 α, Granulocyte-Macrophage Colony-stimulating Factor, and Interferon- γ Release from Alveolar Macrophages in Asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994232499200","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994514432640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin‐10 inhibits cytokine generation from mast 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Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944790939008","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944844219392","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419217181440","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Role of interleukin 10 in specific immunotherapy."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419431656576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894429093248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Predominant T<sub>H2</sub>-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895613460864","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846011938688","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones."}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318683791616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes."}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320065017216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-12 Inhibits Production of Interleukin-5 but Not of Granulocyte/Macrophage Colony-Stimulating Factor by Antigen-Stimulated Blood Mononuclear Cells in Allergic Bronchial Asthmatics"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320196443392","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and 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