{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679610580352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2332/allergolint.08-rai-0019"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD1MXnsFSjug%3D%3D"}},{"identifier":{"@type":"PMID","@value":"18797182"}},{"identifier":{"@type":"URI","@value":"http://api.elsevier.com/content/article/PII:S1323893015307917?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"http://api.elsevier.com/content/article/PII:S1323893015307917?httpAccept=text/plain"}},{"identifier":{"@type":"NAID","@value":"10025108142"}},{"identifier":{"@type":"NAID","@value":"130004476988"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2009186395"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"The Role of Leukotriene B4 in Allergic Diseases"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is a lipid mediator with potent chemoattractant properties and that is rapidly generated from activated innate immune cells such as neutrophils, macrophages, and mast cells. Elevated levels of LTB<sub>4</sub> have been reported in various allergic diseases and these levels have been related to disease activity and response to treatment. Recent studies using LTB<sub>4</sub> receptor-1 (BLT1) antagonists or BLT1-deficient mice have revealed that ligation of BLT1 by LTB<sub>4</sub> is important for the activation and recruitment of inflammatory cells including neutrophils, eosinophils, monocytes/macrophages, mast cells, dendritic cells, and more recently, effector T cells to inflamed tissues in various inflammatory diseases. The LTB<sub>4</sub>/BLT1 pathway appears to play an important role in the pathogenesis of severe persistent asthma, aspirin- and exercise-induced asthma, allergic rhinitis, and atopic dermatitis together with other mediators including cysteinyl leukotrienes, cytokines, and chemokines. LTB<sub>4</sub> production is in general resistant to corticosteroid treatment. In fact, corticosteroids can upregulate BLT1 expression on corticosteroid-resistant inflammatory cells such as neutrophils, monocytes, and effector memory CD8<sup>+</sup> T cells. As a result, this corticosteroid-resistant LTB<sub>4</sub>/BLT1 pathway may contribute to the development of inflammation in allergic diseases that do not respond to the introduction of corticosteroids. Inhibition of this pathway has potential therapeutic benefit in various allergic diseases that have involvement of corticosteroid-insensitivity.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751156466816","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90553876"},{"@type":"NRID","@value":"1000090553876"},{"@type":"NRID","@value":"9000001207931"},{"@type":"NRID","@value":"9000016382367"},{"@type":"NRID","@value":"9000021925577"},{"@type":"NRID","@value":"9000001817925"},{"@type":"NRID","@value":"9000257948522"},{"@type":"NRID","@value":"9000002566848"},{"@type":"NRID","@value":"9000283110076"},{"@type":"NRID","@value":"9000366498694"},{"@type":"NRID","@value":"9000389551731"},{"@type":"NRID","@value":"9000265535087"},{"@type":"NRID","@value":"9000328998017"},{"@type":"NRID","@value":"9000410905459"},{"@type":"NRID","@value":"9000017563965"},{"@type":"NRID","@value":"9000378128443"},{"@type":"NRID","@value":"9000240218647"},{"@type":"NRID","@value":"9000267783129"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0096900"}],"foaf:name":[{"@language":"en","@value":"Ohnishi Hiroshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Cell Biology, Department of Pediatrics, National Jewish Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801200468992","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70335610"},{"@type":"NRID","@value":"1000070335610"},{"@type":"NRID","@value":"9000326651152"},{"@type":"NRID","@value":"9000413572740"},{"@type":"NRID","@value":"9000016382368"},{"@type":"NRID","@value":"9000244881526"},{"@type":"NRID","@value":"9000240023813"},{"@type":"NRID","@value":"9000411587968"},{"@type":"NRID","@value":"9000410343054"},{"@type":"NRID","@value":"9000391592388"},{"@type":"NRID","@value":"9000362268354"},{"@type":"NRID","@value":"9000412189574"},{"@type":"NRID","@value":"9000415396715"},{"@type":"NRID","@value":"9000018136039"},{"@type":"NRID","@value":"9000024817464"},{"@type":"NRID","@value":"9000331445951"},{"@type":"NRID","@value":"9000006864996"},{"@type":"NRID","@value":"9000020336583"},{"@type":"NRID","@value":"9000256522257"},{"@type":"NRID","@value":"9000241847614"},{"@type":"NRID","@value":"9000024817381"},{"@type":"NRID","@value":"9000257948523"},{"@type":"NRID","@value":"9000414490866"},{"@type":"NRID","@value":"9000345383571"},{"@type":"NRID","@value":"9000411581397"},{"@type":"NRID","@value":"9000326665733"},{"@type":"NRID","@value":"9000000381817"},{"@type":"NRID","@value":"9000391659047"},{"@type":"NRID","@value":"9000240055776"},{"@type":"NRID","@value":"9000256521558"},{"@type":"NRID","@value":"9000408628348"},{"@type":"NRID","@value":"9000368412732"},{"@type":"NRID","@value":"9000410627780"},{"@type":"NRID","@value":"9000406036323"},{"@type":"NRID","@value":"9000308381793"},{"@type":"NRID","@value":"9000327439983"},{"@type":"NRID","@value":"9000414490831"},{"@type":"NRID","@value":"9000258061873"},{"@type":"NRID","@value":"9000412585641"},{"@type":"NRID","@value":"9000378071085"},{"@type":"NRID","@value":"9000256521750"},{"@type":"NRID","@value":"9000408628356"},{"@type":"NRID","@value":"9000333083857"},{"@type":"NRID","@value":"9000413373426"},{"@type":"NRID","@value":"9000408451967"},{"@type":"NRID","@value":"9000273021939"},{"@type":"NRID","@value":"9000256522449"},{"@type":"ORCID","@value":"0000-0002-8616-0886"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ayamoe"}],"foaf:name":[{"@language":"en","@value":"Miyahara Nobuaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679610580352","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000016382369"},{"@type":"NRID","@value":"9000257948524"}],"foaf:name":[{"@language":"en","@value":"Gelfand Erwin W"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Cell Biology, Department of Pediatrics, National Jewish Health"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13238930"},{"@type":"LISSN","@value":"13238930"},{"@type":"EISSN","@value":"14401592"},{"@type":"NCID","@value":"AA11091750"}],"prism:publicationName":[{"@language":"en","@value":"Allergology International"},{"@language":"en","@value":"Allergol. Int."}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Allergology"},{"@language":"ja","@value":"一般社団法人日本アレルギー学会"}],"prism:publicationDate":"2008","prism:volume":"57","prism:number":"4","prism:startingPage":"291","prism:endingPage":"298"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://api.elsevier.com/content/article/PII:S1323893015307917?httpAccept=text/xml"},{"@id":"http://api.elsevier.com/content/article/PII:S1323893015307917?httpAccept=text/plain"},{"@id":"https://search.jamas.or.jp/link/ui/2009186395"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=allergic%20conjunctivitis","dc:title":"allergic conjunctivitis"},{"@id":"https://cir.nii.ac.jp/all?q=allergic%20rhinitis","dc:title":"allergic rhinitis"},{"@id":"https://cir.nii.ac.jp/all?q=asthma","dc:title":"asthma"},{"@id":"https://cir.nii.ac.jp/all?q=atopic%20dermatitis","dc:title":"atopic dermatitis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050565162804131968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233462576512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144236485888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Eicosanoids in skin of patients with atopic dermatitis: Prostaglandin E2 and leukotriene B4 are present in biologically active concentrations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144605675392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bronchial CD8 Cell Infiltrate and Lung Function Decline in Asthma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144734854912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leukotriene B4 Receptor-1 Is Essential for Allergen-Mediated Recruitment of CD8+ T Cells and Airway Hyperresponsiveness"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146052263936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Leukotriene B4 level in neutrophils from allergic and healthy subjects stimulated by low concentration of calcium ionophore A23187. 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