Acute pancreatitis and innate immunity

DOI Web Site 37 References
  • TSUJI Yoshihisa
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine
  • WATANABE Tomohiro
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine
  • CHIBA Tsutomu
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine

Bibliographic Information

Other Title
  • 急性膵炎におけるInnate Immunity
Published
2014
DOI
  • 10.2958/suizo.29.45
Publisher
Japan Pancreas Society

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Description

It has been generally accepted that pathogenic intra-acinar trypsinogen activation followed by auto-digestion of the pancreas plays a critical role in the development of acute pancreatitis. However, recent studies suggest that auto-digestion by activated trypsin alone cannot fully account for the pathogenesis of acute pancreatitis since experimental acute pancreatitis is successfully induced even without the full-activation of trypsinogen. Although intra-acinar trypsinogen activation followed by auto-digestion of the pancreas is an initial step of acute pancreatitis, pathogenic immune reactions are involved in the sustained pancreatic inflammation. In this regard, recent studies highlight the importance of innate immune responses mediated by intestinal microflora translocated into the pancreas and by endogenous auto-antigens released from the necrotic pancreatic tissue.<br>

Journal

  • Suizo

    Suizo 29 (1), 45-50, 2014

    Japan Pancreas Society

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