{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679617300992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2745/dds.19.511"}},{"identifier":{"@type":"NAID","@value":"10014117174"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2005057907"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Polymer-coated liposomes for oral drug delivery"},{"@value":"リポソームとＤＤＳ　　経口ドラッグキャリアとしてのポリマーコーティングリポソーム"}],"dcterms:alternative":[{"@language":"en","@value":"Polymer-coated liposomes for oral drug delivery"},{"@value":"経口ドラッグキャリアとしてのポリマーコーティングリポソーム"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Mucoadhesive liposomal systems were developed for oral delivery of poorly absorbable drugs such as peptide drugs. The novel drug delivery systems could be prepared by coating the surface of liposomes containing the drugs with mucoadhesive polymers such as chitosan and Carbopol. Improvement of peptide drug absorption with the polymer coated liposomes was demonstrated in rats. The penetration of the liposomal systems into the mucosa of rat intestines was observed with confocal laser scanning microscopy as well as their retentive properties in the intestinal tract. Immunological response was also detected in oral administration of the chitosan-coated liposomes containing ovalbumin."},{"@value":"ペプチド性薬物のような難吸収性薬物の経口投与を目指して, 新しいリポソームシステムを考案した. そのシステムは, リポソーム表面をキトサンやカーボポールといった粘膜付着性ポリマーでコーティングすることによって調製することが出来る. ラットを用いた実験でインスリン, カルシトニンなどの消化管吸収改善を示すことが出来た. 腸管内での滞留性向上とともに, 粘膜組織にそのリポソームが浸入している様子が共焦点レーザー顕微鏡を用いて観察された. また, 卵アルブミンを封入したキトサンコーティングリポソームを用いて経口免疫性剤としての有用性を示す結果も得られている."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801209080064","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50171616"},{"@type":"NRID","@value":"1000050171616"},{"@type":"NRID","@value":"9000400185320"},{"@type":"NRID","@value":"9000400185355"},{"@type":"NRID","@value":"9000400185933"},{"@type":"NRID","@value":"9000400185963"},{"@type":"NRID","@value":"9000402084958"},{"@type":"NRID","@value":"9000021940366"},{"@type":"NRID","@value":"9000347641560"},{"@type":"NRID","@value":"9000243905114"},{"@type":"NRID","@value":"9000254731786"},{"@type":"NRID","@value":"9000398301740"},{"@type":"NRID","@value":"9000255958409"},{"@type":"NRID","@value":"9000003827391"},{"@type":"NRID","@value":"9000254691868"},{"@type":"NRID","@value":"9000400185948"},{"@type":"NRID","@value":"9000400184809"},{"@type":"NRID","@value":"9000369747155"},{"@type":"NRID","@value":"9000254230869"},{"@type":"NRID","@value":"9000254732106"},{"@type":"NRID","@value":"9000297486290"},{"@type":"NRID","@value":"9000377383025"},{"@type":"NRID","@value":"9000363983072"},{"@type":"NRID","@value":"9000002271055"},{"@type":"NRID","@value":"9000254226371"},{"@type":"NRID","@value":"9000254731010"},{"@type":"NRID","@value":"9000254707227"},{"@type":"NRID","@value":"9000254687357"},{"@type":"NRID","@value":"9000240034828"},{"@type":"NRID","@value":"9000016984131"},{"@type":"NRID","@value":"9000403411846"},{"@type":"NRID","@value":"9000254243288"},{"@type":"NRID","@value":"9000254243070"},{"@type":"NRID","@value":"9000254706296"},{"@type":"NRID","@value":"9000400185337"},{"@type":"NRID","@value":"9000402084930"},{"@type":"NRID","@value":"9000403937853"},{"@type":"NRID","@value":"9000311504054"},{"@type":"NRID","@value":"9000254225060"},{"@type":"NRID","@value":"9000254219023"},{"@type":"NRID","@value":"9000400185331"},{"@type":"NRID","@value":"9000400185314"},{"@type":"NRID","@value":"9000402084964"},{"@type":"NRID","@value":"9000400184781"},{"@type":"NRID","@value":"9000019947873"},{"@type":"NRID","@value":"9000254732275"},{"@type":"NRID","@value":"9000258225402"},{"@type":"NRID","@value":"9000258681541"},{"@type":"NRID","@value":"9000019214646"},{"@type":"NRID","@value":"9000400185333"},{"@type":"NRID","@value":"9000400185323"},{"@type":"NRID","@value":"9000400185955"},{"@type":"NRID","@value":"9000021107810"},{"@type":"NRID","@value":"9000021143331"},{"@type":"NRID","@value":"9000283717021"},{"@type":"NRID","@value":"9000345288822"},{"@type":"NRID","@value":"9000254255404"},{"@type":"NRID","@value":"9000254255407"},{"@type":"NRID","@value":"9000254730183"},{"@type":"NRID","@value":"9000403034726"},{"@type":"NRID","@value":"9000256046096"},{"@type":"NRID","@value":"9000392641978"},{"@type":"NRID","@value":"9000400185350"},{"@type":"NRID","@value":"9000402084935"},{"@type":"NRID","@value":"9000402084138"},{"@type":"NRID","@value":"9000021283909"},{"@type":"NRID","@value":"9000369337995"},{"@type":"NRID","@value":"9000364000034"},{"@type":"NRID","@value":"9000400185939"},{"@type":"NRID","@value":"9000020063214"},{"@type":"NRID","@value":"9000399344573"},{"@type":"NRID","@value":"9000242137210"},{"@type":"NRID","@value":"9000390924566"},{"@type":"NRID","@value":"9000344832055"},{"@type":"NRID","@value":"9000402084914"},{"@type":"NRID","@value":"9000402084953"},{"@type":"NRID","@value":"9000400184829"},{"@type":"NRID","@value":"9000254240030"},{"@type":"NRID","@value":"9000254730291"},{"@type":"NRID","@value":"9000254707418"},{"@type":"NRID","@value":"9000254715741"},{"@type":"NRID","@value":"9000283245038"},{"@type":"NRID","@value":"9000002157998"},{"@type":"NRID","@value":"9000002467844"},{"@type":"NRID","@value":"9000363982645"},{"@type":"NRID","@value":"9000392643654"},{"@type":"NRID","@value":"9000400185361"},{"@type":"NRID","@value":"9000400185367"},{"@type":"NRID","@value":"9000400185917"},{"@type":"NRID","@value":"9000400185929"},{"@type":"NRID","@value":"9000400185946"},{"@type":"NRID","@value":"9000400184807"},{"@type":"NRID","@value":"9000400184797"},{"@type":"NRID","@value":"9000402084124"},{"@type":"NRID","@value":"9000254729997"},{"@type":"NRID","@value":"9000254709504"},{"@type":"NRID","@value":"9000254705507"},{"@type":"NRID","@value":"9000400185359"},{"@type":"NRID","@value":"9000400185927"},{"@type":"NRID","@value":"9000402084911"},{"@type":"NRID","@value":"9000254228778"},{"@type":"NRID","@value":"9000254241378"},{"@type":"NRID","@value":"9000254729719"},{"@type":"NRID","@value":"9000254691552"},{"@type":"NRID","@value":"9000254701071"},{"@type":"NRID","@value":"9000242731606"},{"@type":"NRID","@value":"9000400185343"},{"@type":"NRID","@value":"9000402084923"},{"@type":"NRID","@value":"9000402084113"},{"@type":"NRID","@value":"9000282408220"},{"@type":"NRID","@value":"9000282408224"},{"@type":"NRID","@value":"9000020223771"},{"@type":"NRID","@value":"9000021916449"},{"@type":"NRID","@value":"9000312722093"},{"@type":"NRID","@value":"9000350643298"},{"@type":"NRID","@value":"9000254227831"},{"@type":"NRID","@value":"9000254705805"},{"@type":"NRID","@value":"9000258615352"},{"@type":"NRID","@value":"9000402084969"},{"@type":"NRID","@value":"9000402084936"},{"@type":"NRID","@value":"9000402084130"},{"@type":"NRID","@value":"9000020711854"},{"@type":"NRID","@value":"9000021265936"},{"@type":"NRID","@value":"9000296662764"},{"@type":"NRID","@value":"9000254706320"},{"@type":"NRID","@value":"9000399344297"},{"@type":"NRID","@value":"9000008986684"},{"@type":"NRID","@value":"9000007348093"},{"@type":"NRID","@value":"9000400184791"},{"@type":"NRID","@value":"9000400184787"},{"@type":"NRID","@value":"9000402084119"},{"@type":"NRID","@value":"9000020864373"},{"@type":"NRID","@value":"9000254704620"},{"@type":"NRID","@value":"9000254702220"},{"@type":"NRID","@value":"9000412546643"},{"@type":"NRID","@value":"9000402462627"},{"@type":"NRID","@value":"9000254227839"},{"@type":"NRID","@value":"9000400185325"},{"@type":"NRID","@value":"9000400185345"},{"@type":"NRID","@value":"9000399846969"},{"@type":"NRID","@value":"9000400184815"},{"@type":"NRID","@value":"9000398134901"},{"@type":"NRID","@value":"9000258662662"},{"@type":"NRID","@value":"9000241574982"},{"@type":"NRID","@value":"9000363277128"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0020149"}],"foaf:name":[{"@language":"en","@value":"Takeuchi Hirofumi"},{"@language":"ja","@value":"竹内 洋文"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Gifu Pharmaceutical University"},{"@language":"ja","@value":"岐阜薬科大学製剤学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09135006"},{"@type":"EISSN","@value":"18812732"},{"@type":"CODEN","@value":"DDSYEI"},{"@type":"NCID","@value":"AN10084591"}],"prism:publicationName":[{"@language":"en","@value":"Drug Delivery System"},{"@language":"ja","@value":"Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ"},{"@language":"en","@value":"DDS"},{"@language":"en","@value":"Official Journal of the Japan Society of Drug Delivery System"},{"@language":"ja","@value":"ＤＤＳ"}],"dc:publisher":[{"@language":"en","@value":"THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM"},{"@language":"ja","@value":"日本DDS学会"}],"prism:publicationDate":"2004","prism:volume":"19","prism:number":"6","prism:startingPage":"511","prism:endingPage":"519"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2005057907"}],"availableAt":"2004","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=liposomes","dc:title":"liposomes"},{"@id":"https://cir.nii.ac.jp/all?q=surface%20modification","dc:title":"surface modification"},{"@id":"https://cir.nii.ac.jp/all?q=oral%20administration","dc:title":"oral administration"},{"@id":"https://cir.nii.ac.jp/all?q=mucoadhesion","dc:title":"mucoadhesion"},{"@id":"https://cir.nii.ac.jp/all?q=peptide%20drugs","dc:title":"peptide drugs"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781782044288","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"14370731"},{"@type":"JGN","@value":"JP14370731"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370731/"}],"notation":[{"@language":"ja","@value":"薬物精密送達のための微粒子製剤設計と生体応答に関する研究"},{"@language":"en","@value":"Studies on nano-particulate systems and their bio-response for drug delivery"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145534187520","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Comparative, Quantitative Study of Lymphoid and Non-Lymphoid Uptake of 60 nm Polystyrene Particles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145830634112","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"HYPOGLYCqMIC EFFECT OF LIPOSOME-ENTRAPPED INSULIN ADMINISTERED INTRAGASTRICALLY INTO RATS"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893842830336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated Liposomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895610598656","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793711863296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mucoadhesive nanoparticulate systems for peptide drug delivery"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795373867520","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238085334016","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Drug Delivery Systems for Highly Efficient and Non-Stimulating Drug Therapy"},{"@language":"ja","@value":"高効率・低侵襲の薬物治療のためのDDS開発"}]},{"@id":"https://cir.nii.ac.jp/crid/1390845712998243328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"CNTプローブAFM法によるキトサン修飾リポソームとムチン間相互作用の評価"},{"@language":"en","@value":"Characterization of Surface Interaction between Chitosan-modified Liposomes and Mucin Layer by Using CNT Probe AFM Method"},{"@language":"ja-Kana","@value":"CNT プローブ AFMホウ ニ ヨル キトサン シュウショク リポソーム ト ムチン カン ソウゴ サヨウ ノ ヒョウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1523669554575008512","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"薬物キャリアとしてのリポソーム,リピッドマイクロスフェアに関する製剤学的研究"},{"@language":"ja-Kana","@value":"ヤクブツ キャリア トシテノ リポソーム リピッド マイクロスフェア ニ カン"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009751804485376","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1570291225877829504","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gastrointestinal uptake of biodegradable microparticles : effect of particle size"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175174736128","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier in the small intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176486012544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Oral administration of insulin by encapsulation within liposomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176761490688","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571135650151446016","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571135651689241216","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571417126628551552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Intracellular digestion of saturated and unsaturated phospholipid liposomes by mucosal cells. Possible mechanism of transport of liposomally entrapped macromolecules across the isolated vascularly perfused rabbit ileum"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417127325382272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mucoadhesion of polymer-coated liposomes to rat intestine in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601271610496","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transmucosal passage of liposomally entrapped drugs in rat small intestine"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075081579776","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Polymer coated liposomes for drug delivery to target specific organs Recent Advances in Drug Delivery Systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261548957204992","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572261550058290688","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543025034998656","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Experimental methods for determination of bioadhesive bond strength of polymers with mucus"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025034999808","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572543025035000704","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500673459072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The oral absorption of micro- and nano-particulates : neither exceptional nor unusual"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450627182208","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668924941843456","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573668926472235904","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The stability and functional properties of proteoliposomes mixed with dextran derivatives bearing hydrophobic anchor groups"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400580604416","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950401436771968","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231874895263872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of entrapped markers on the in situ jejunal uptake from liposomal systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876404402560","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1574231876448679296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0024570563"},{"@type":"CROSSREF","@value":"10.2745/dds.19.511"},{"@type":"CIA","@value":"10014117174"},{"@type":"KAKEN","@value":"PRODUCT-17797287"},{"@type":"CROSSREF","@value":"10.1248/yakushi.18-00015_references_DOI_LfFC9MFMa27FXyQJk0WtM0v29vI"}]}