{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679618153472.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2745/dds.15.32"}},{"identifier":{"@type":"NAID","@value":"10007334024"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2000121026"}}],"dc:title":[{"@language":"en","@value":"Drug delivery system for cancer gene therapy-A review."},{"@value":"癌治療とＤＤＳ　　癌の遺伝子治療におけるＤＤＳ"}],"dcterms:alternative":[{"@language":"en","@value":"Drug delivery system for cancer gene therapy—A review"},{"@value":"癌の遺伝子治療におけるDDS"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Drug delivery system (DDS), currently employed for cancer gene therapy was reviewed. There have been at least four systems hitherto developed to deliver the anticancer genes to tumor. They include 1) modified liposome system such as cationic liposorne, HVJ-liposme, transferrin conjugated liposome etc. 2) naked plasmid DNA conjugated with ligand or antibody which are known to interact with receptor or antigen on tumor cells. 3) viral vectors such as retroviral vector, adenoviral vector, lenti viral vector, adenoassociated viral vector etc. 4) replication competent oncolytic viruses such as E 1 B attenuated adenovirus or genetically modified herpes simplex virus. Although most of these delivery systems are found to be applicable for local administration of transgene, little success has been reported as to specific targeting to tumor by systemic administration. Therefore efforts are now focusing on the development of devise to target tumor <I>in vivo</I>."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679618153473","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Takahashi Minoru"},{"@language":"ja","@value":"高橋 稔"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine"},{"@language":"ja","@value":"札幌医科大学第四内科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326213725952","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80343383"},{"@type":"NRID","@value":"1000080343383"},{"@type":"NRID","@value":"9000002282966"},{"@type":"NRID","@value":"9000413918071"},{"@type":"NRID","@value":"9000413376250"},{"@type":"NRID","@value":"9000282391134"},{"@type":"NRID","@value":"9000259835554"},{"@type":"NRID","@value":"9000300215420"},{"@type":"NRID","@value":"9000303995903"},{"@type":"NRID","@value":"9000258040409"},{"@type":"NRID","@value":"9000258042924"},{"@type":"NRID","@value":"9000329006414"},{"@type":"NRID","@value":"9000413743557"},{"@type":"NRID","@value":"9000311506903"},{"@type":"NRID","@value":"9000256350655"},{"@type":"NRID","@value":"9000314074292"},{"@type":"NRID","@value":"9000248227954"},{"@type":"NRID","@value":"9000400188923"},{"@type":"NRID","@value":"9000410272786"},{"@type":"NRID","@value":"9000398801063"},{"@type":"NRID","@value":"9000258043110"},{"@type":"NRID","@value":"9000258038911"},{"@type":"NRID","@value":"9000022058477"},{"@type":"NRID","@value":"9000411000573"},{"@type":"NRID","@value":"9000255802898"},{"@type":"NRID","@value":"9000413743533"},{"@type":"NRID","@value":"9000410615727"},{"@type":"NRID","@value":"9000412365171"},{"@type":"NRID","@value":"9000283539833"},{"@type":"NRID","@value":"9000412284060"},{"@type":"NRID","@value":"9000411545882"},{"@type":"NRID","@value":"9000411033750"},{"@type":"NRID","@value":"9000256348998"},{"@type":"NRID","@value":"9000409014636"},{"@type":"NRID","@value":"9000309571810"},{"@type":"NRID","@value":"9000243890364"},{"@type":"NRID","@value":"9000256351427"},{"@type":"NRID","@value":"9000248229564"},{"@type":"NRID","@value":"9000018606954"},{"@type":"NRID","@value":"9000400188941"},{"@type":"NRID","@value":"9000415312954"},{"@type":"NRID","@value":"9000356648383"},{"@type":"NRID","@value":"9000413699722"},{"@type":"NRID","@value":"9000411983981"},{"@type":"NRID","@value":"9000412226099"},{"@type":"NRID","@value":"9000242565816"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0083229"}],"foaf:name":[{"@language":"en","@value":"Sato Yasushi"},{"@language":"ja","@value":"佐藤 康史"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine"},{"@language":"ja","@value":"札幌医科大学第四内科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679618153474","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001051353"}],"foaf:name":[{"@language":"en","@value":"Niitsu Yoshiro"},{"@language":"ja","@value":"新津 洋司郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine"},{"@language":"ja","@value":"札幌医科大学第四内科学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09135006"},{"@type":"EISSN","@value":"18812732"},{"@type":"CODEN","@value":"DDSYEI"},{"@type":"NCID","@value":"AN10084591"}],"prism:publicationName":[{"@language":"en","@value":"Drug Delivery System"},{"@language":"ja","@value":"Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ"},{"@language":"en","@value":"DDS"},{"@language":"en","@value":"Official Journal of the Japan Society of Drug Delivery System"},{"@language":"ja","@value":"ＤＤＳ"}],"dc:publisher":[{"@language":"en","@value":"THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM"},{"@language":"ja","@value":"日本DDS学会"}],"prism:publicationDate":"2000","prism:volume":"15","prism:number":"1","prism:startingPage":"32","prism:endingPage":"38"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2000121026"}],"availableAt":"2000","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=viral%20vector","dc:title":"viral vector"},{"@id":"https://cir.nii.ac.jp/all?q=liposome","dc:title":"liposome"},{"@id":"https://cir.nii.ac.jp/all?q=ligand%20conjugated%20plasmid%20DNA","dc:title":"ligand conjugated plasmid DNA"},{"@id":"https://cir.nii.ac.jp/all?q=antibody%20conjugated%20plasmid%20DNA","dc:title":"antibody conjugated plasmid DNA"},{"@id":"https://cir.nii.ac.jp/all?q=replication%20competent%20oncolytic%20virus","dc:title":"replication competent oncolytic virus"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360855570340418944","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Gene gun and other non-viral approaches for cancer gene therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468760945920","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844165645440","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Hydrodynamics-based transfection in animals by systemic administration of plasmid 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