書誌事項
- タイトル別名
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- The comparison in double immunodiffusion and western blotting methods of anti-SS-A/B antibodies in patients with Sjoegren's syndrome
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説明
Objective: To investigate the autoimmune responses against SS-A/B antigens by double immunodiffusion (DID) and western blotting (WB) in primary and secondary Sjögren's syndrome (SS).<br> Patients: Forty-nine patients with primary SS (PSS), 28 patients with secondary SS (SSS) and control group that couldn't be diagnosed as SS were included in this study.<br> Results: In DID analysis, Anti-SS-A antibody was detected in 69% of PSS and 86% of SSS, and anti-SS-B antibody was found in 22% of PSS and 39% of SSS. No significant difference could be demonstrated between PSS and SSS concerning anti-SS-A/B antibodies. Conversely, WB studies disclosed evidences that 18% of PSS and no SSS reacted only with the 52 kD protein, and there was significantly increased in PSS. Sera reacting with the 60 kD antigen were found in 37% of PSS, 71% of SSS, and 75% of SSS with SLE, 63% of SSS with RA. The ratio of SSS, and SSS with SLE were particularly significantly higher than PSS.<br> Conclusion: Our results revealed data that there are the difference of reactivity against SS-A/B antigens in WB between PSS and SSS.
収録刊行物
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- 日本臨床免疫学会会誌
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日本臨床免疫学会会誌 26 (2), 74-79, 2003
日本臨床免疫学会
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詳細情報 詳細情報について
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- CRID
- 1390282679627290496
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- NII論文ID
- 130000849653
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- NII書誌ID
- AN00357971
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- ISSN
- 13497413
- 09114300
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- PubMed
- 12760104
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- PubMed
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- 抄録ライセンスフラグ
- 使用不可