{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679627362944.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2177/jsci.23.30"}},{"identifier":{"@type":"PMID","@value":"10771570"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jsci1978/23/1/23_1_30/_pdf"}},{"identifier":{"@type":"NAID","@value":"10005222889"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2000168397"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Hypersensitivity peumonitis in a patient with rheumatoid arthritis."},{"@value":"過敏性肺臓炎を合併した慢性関節リウマチの１例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We report a case with rheumatoid arthritis and hypersensitivity pneumonitis. A 66-year-old female was admitted to our hospital because of fever, cough, and progressive dyspnea on October 10, 1997. She had a history of rheumatoid arthritis from 1987 and was treated with cyclophosphamide when she developed pulmonary symptoms in September 1997. On admission arthritis was subsided. Fine crackles on ausculation of lung, hypoxia, ground-glass appearance on chest X-ray were detected. The computed tomography of the chest disclosed diffuse interstitial shadow with patchy destruction of alveolar structures. Bronchoalveolar lavage demonstrated an increase in lymphocytes with predominance of suppressor-cytotoxic T cell subset (CD 8<sup>+</sup>). The histopathological examination of transbronchial lung biopsy showed interstitial inflammation with marked predominance of lymphocyte with intraalveolar exudate. Her condition got better and she discharged without definitive diagnosis and treatment for her respiratory symptoms. Eight hours after she went back home, she suddenly presented high fever and cough and gradually developed dyspnea. She was readmitted 5 days after the previous discharge. Although no specific precipitin antibody against various microorganisms was detected in her sera, the diagnosis of hypersensitivity pneumonitis was made. Thirty mg per day of prednisolone was resolved her symptoms promptly.<br> There was no reported case with hypersensitivity pneumonitis and rheumatoid arthritis of other collagen diseases. The clinical course that arthritis and pulmonary symptoms appeared alternatively is of considerable intrest to investigate for the pathogenesis of these two immune disorders."},{"@value":"症例は66歳,女性. 1987年に慢性関節リウマチ(RA)に罹患し加療されるも活動性関節炎が持続. 1997年9月下旬より,発熱・咳嗽に続き呼吸困難が出現.それとともに関節炎は軽快.胸部単純X線写真で両下肺野のびまん性散布性粒状陰影と著明な低酸素血症が認められ10月10日入院.胸部CTで両肺野のびまん性スリガラス様陰影,気管支肺胞洗浄液でリンパ球優位の細胞数増加とCD4<sup>+</sup>/CD8<sup>+</sup>細胞比の低下,経気管支肺生検で著明な胞隔炎を認めた.肺病変の原因は確診に至らなかった.呼吸器症状の改善とともに関節炎は再燃したが, 11月30日退院.帰宅8時間後に発熱し,咳嗽・呼吸困難もきたし, 12月5日に再入院.血清学的検査で原因抗原を特定できなかったが,臨床症状,経過,諸検査の所見から,過敏性肺臓炎(HP)と診断した. RAとHPの合併の報告はなく, HP発症とともにRAの関節炎が軽快するという経過をとった興味ある1例と考え報告する."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751155865728","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90211432"},{"@type":"NRID","@value":"1000090211432"},{"@type":"NRID","@value":"9000000973980"},{"@type":"NRID","@value":"9000018552004"},{"@type":"NRID","@value":"9000280554932"},{"@type":"NRID","@value":"9000262367084"},{"@type":"NRID","@value":"9000259337181"},{"@type":"NRID","@value":"9000262367030"},{"@type":"NRID","@value":"9000020563298"},{"@type":"NRID","@value":"9000258418558"},{"@type":"NRID","@value":"9000020357149"},{"@type":"NRID","@value":"9000001182723"},{"@type":"NRID","@value":"9000265566103"},{"@type":"NRID","@value":"9000240536367"},{"@type":"NRID","@value":"9000259336863"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ayakonkjm"}],"foaf:name":[{"@language":"en","@value":"Nakajima Ayako"},{"@language":"ja","@value":"中島 亜矢子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Divisin of Rheumatic Disease, Tokyo Metropolitan Ohtsuka Hospital"},{"@language":"ja","@value":"東京都立大塚病院リウマチ膠原病科"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133697598592","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30187819"},{"@type":"NRID","@value":"1000030187819"},{"@type":"NRID","@value":"9000350568752"},{"@type":"NRID","@value":"9000000973913"},{"@type":"NRID","@value":"9000391778828"},{"@type":"NRID","@value":"9000364811797"},{"@type":"NRID","@value":"9000391408362"},{"@type":"NRID","@value":"9000391778584"},{"@type":"NRID","@value":"9000283723274"},{"@type":"NRID","@value":"9000006515798"},{"@type":"NRID","@value":"9000253177991"},{"@type":"NRID","@value":"9000391775631"},{"@type":"NRID","@value":"9000001000432"},{"@type":"NRID","@value":"9000021645936"},{"@type":"NRID","@value":"9000350568800"},{"@type":"NRID","@value":"9000391778620"},{"@type":"NRID","@value":"9000020563139"},{"@type":"NRID","@value":"9000007158836"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0163866"}],"foaf:name":[{"@language":"en","@value":"Suwa Akira"},{"@language":"ja","@value":"諏訪 昭"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Divisin of Rheumatic Disease, Tokyo Metropolitan Ohtsuka Hospital"},{"@language":"ja","@value":"東京都立大塚病院リウマチ膠原病科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679626476800","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003757844"}],"foaf:name":[{"@language":"en","@value":"Suzuki Takahiro"},{"@language":"ja","@value":"鈴木 貴博"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Institute of Rheumatology, Tokyo Women's Medical University"},{"@language":"ja","@value":"東京女子医科大学膠原病リウマチ痛風センター"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679627362945","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000005801877"}],"foaf:name":[{"@language":"en","@value":"Tanaka Michi"},{"@language":"ja","@value":"田中 みち"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Divisin of Rheumatic Disease, Tokyo Metropolitan Ohtsuka Hospital"},{"@language":"ja","@value":"東京都立大塚病院リウマチ膠原病科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204648326536","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000338950"}],"foaf:name":[{"@language":"en","@value":"Yamada Takashi"},{"@language":"ja","@value":"山田 隆"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Divisin of Rheumatic Disease, Tokyo Metropolitan Ohtsuka Hospital"},{"@language":"ja","@value":"東京都立大塚病院リウマチ膠原病科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204648326530","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000003753003"}],"foaf:name":[{"@language":"en","@value":"Inada Shinichi"},{"@language":"ja","@value":"稲田 進一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Divisin of Rheumatic Disease, Tokyo Metropolitan Ohtsuka Hospital"},{"@language":"ja","@value":"東京都立大塚病院リウマチ膠原病科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09114300"},{"@type":"EISSN","@value":"13497413"},{"@type":"NCID","@value":"AN00357971"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Clinical Immunology"},{"@language":"ja","@value":"日本臨床免疫学会会誌"},{"@language":"en","@value":"Jpn. J. Clin. Immunol."},{"@language":"ja","@value":"日臨免誌"},{"@language":"en","@value":"Jpn.J.clin.Immun"}],"dc:publisher":[{"@language":"en","@value":"The Japan Society for Clinical Immunology"},{"@language":"ja","@value":"日本臨床免疫学会"}],"prism:publicationDate":"2000","prism:volume":"23","prism:number":"1","prism:startingPage":"30","prism:endingPage":"36"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/jsci1978/23/1/23_1_30/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2000168397"}],"availableAt":"2000","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=hypersensitivity%20pneumonitis","dc:title":"hypersensitivity pneumonitis"},{"@id":"https://cir.nii.ac.jp/all?q=rheumatoid%20arthritis","dc:title":"rheumatoid arthritis"},{"@id":"https://cir.nii.ac.jp/all?q=interstitial%20pneumonia","dc:title":"interstitial pneumonia"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1363388846222554624","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Th1/Th2 cytokine balance in arthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1523388079753286016","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"過敏性肺臓炎--現況,病態,診断,治療と予防"},{"@language":"ja-Kana","@value":"カビンセイ ハイゾウエン ゲンキョウ ビョウタイ シンダン チリョウ ト ヨボ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749447825792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Experimental hypersensitivity pneumonitis : in vitro effects of interleukin-2 and interferongamma"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224424530816","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lung diseases in the tropics"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224424531968","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pigeon breeder's lung : association with HLA-DR 3"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699401246592","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interferon-γ is necessary for the expression of hypersensitivity pneumonitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854174377696256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Induction of Th 2 cytokines and control of collagen-induced arthritis by nondepleting ant-CD 4 Abs"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854174377953792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanisms accounting for granulomatous responses in hypersensitivity pneumonitis. Sarcoidosis Vasc."}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649354666240","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Is the different T helper cell activity in sarcoidosis and extrinsic allergic alveolitis also reflected by the cellular bronchoalveolar lavage fluid profile?"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074284794624","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HLA-DQw 3 in Japanese summer-type hypersensitivity pneumonitis in duced by Trichosporon cutaneum"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500904575104","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Extrinsic allergic alveoritis (hypersensitivity pneumonitis) : past, present and future"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924145061888","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Th1 CD4^+ cells adoptively transfer experimental hypersensitivity pneumonitis."}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008750113"},{"@type":"CROSSREF","@value":"10.2177/jsci.23.30"},{"@type":"PUBMED","@value":"10771570"},{"@type":"CIA","@value":"10005222889"},{"@type":"OPENAIRE","@value":"doi_dedup___::8751a79c5fbfb92370e76384784fc5c4"}]}