{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679631731840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.7130/hokkaidoshakai.22.3_1"}},{"identifier":{"@type":"NAID","@value":"130003825426"}},{"identifier":{"@type":"NAID","@value":"10016120845"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1997031300"}}],"dc:title":[{"@language":"en","@value":"Fluctuations of leucocytes and complement system in heart-lung machine."},{"@value":"人工心肺下における白血球，補体系の変動"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@value":"体外循環により血液成分が高分子素材に接触して活性化され,全身の炎症反応を引き起こす。体外循環中,白血球数は漸増し120分後には術前より高値となったが,血小板数は逆に減少し硫酸プロタミン投与後に更に低下した。また,β－トロンボグロブリン等の上昇が見られ,血小板の脱顆粒と消費が示唆された。体外循環中にC3a,C4aが増加したがC5aは全く上昇せず,速やかに不活化されているものと思われた。開心術中の顆粒球の活性酸素産生能を化学発光法で調べると,殆ど変化がなく,体外循環は活性酸素産生能に影響しなかった。反対に血清顆粒球エラスターゼは体外循環中に上昇し,顆粒球の活性化が示唆された。エラスターゼを分泌する活性化顆粒球は血管外に遊走し,不活性な顆粒球が循環血液中に残ったものと思われた。ヘパリンコーティング回路はヘパリン投与量の減量だけでなく白血球,補体系の活性化や血小板減少を抑制し,生体への侵襲を軽減し得るものと期待される。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679631731840","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001528616"},{"@type":"NRID","@value":"9000254375610"}],"foaf:name":[{"@language":"ja","@value":"芳賀 佳之"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"浦和市立病院心臓血管外科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09122664"},{"@type":"EISSN","@value":"18845452"},{"@type":"NCID","@value":"AN1020635X"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Extra-Corporeal Technology"},{"@value":"体外循環技術"},{"@language":"ja","@value":"体外循環技術"},{"@language":"en","@value":"JJECT"},{"@language":"ja","@value":"体外循環技術"},{"@language":"en","@value":"Japanese journal of extra-corporeal technology"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Extra-Corporeal Technology in Medicine"},{"@language":"ja","@value":"一般社団法人 日本体外循環技術医学会"}],"prism:publicationDate":"1996","prism:volume":"22","prism:number":"3","prism:startingPage":"1","prism:endingPage":"9"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/1997031300"}],"availableAt":"1996","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E4%BD%93%E5%A4%96%E5%BE%AA%E7%92%B0","dc:title":"体外循環"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%99%BD%E8%A1%80%E7%90%83","dc:title":"白血球"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A1%86%E7%B2%92%E7%90%83%E3%82%A8%E3%83%A9%E3%82%B9%E3%82%BF%E3%83%BC%E3%82%BC","dc:title":"顆粒球エラスターゼ"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%A3%9C%E4%BD%93","dc:title":"補体"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%98%E3%83%91%E3%83%AA%E3%83%B3%E3%82%B3%E3%83%BC%E3%83%86%E3%82%A3%E3%83%B3%E3%82%B0","dc:title":"ヘパリンコーティング"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204654516224","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Study of open heart surgical 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