{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679648652928.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3164/jcbn.2008012"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD1cXotVOht74%3D"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jcbn/42/2/42_2008012/_pdf"}},{"identifier":{"@type":"PMID","@value":"18385822"}},{"identifier":{"@type":"NAID","@value":"130004466508"}}],"dc:title":[{"@language":"en","@value":"Proton Pump Inhibitors and Gastritis"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Proton pump inhibitors (PPIs) are novel compounds that strongly inhibit the H<sup>+</sup>/K<sup>+</sup>-ATPase in the gastric parietal cells to cause profound suppression of acid secretion. Acid-generating ATPase, also known as vacuolar-type ATPase, is located in the lysozomes of leukocytes and osteoclasts and its activity is also reportedly influenced by treatment with PPIs. This concept is supported by the results of studies using autoradiography in which <sup>3</sup>H-Lansoprazole uptake sites were clearly detected in the cytoplasmic granules of neutrophils infiltrating the gastric mucosa. <i>In vitro</i> studies indicate that PPIs increase the intra-vacuolar pH in the lysosomes of purified neutrophils and attenuate the adherence of neutrophils to the vascular endothelium. In clinical practice, the acidic environment in the stomach plays a critical role in the development of gastritis induced by <i>Helicobacter pylori</i> (<i>H. pylori</i>). This is worthy of note, because persistent gastritis often results in atrophic and metaplastic changes in the gastric mucosa, which are believed to be preneoplastic abnormalities. In patients with <i>H. pylori</i>-infection, PPI therapy causes corpus-predominant gastritis, which is frequently found in the background mucosa in patients with gastric cancer. The efficacy and safety of long-term PPI-treatment have not been conclusive, thus we need to pay more attention to the additional pharmacological actions of PPIs.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679648652929","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000257905887"}],"foaf:name":[{"@language":"en","@value":"Suzuki Masayuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Gastroenterology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751164801280","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70255454"},{"@type":"NRID","@value":"1000070255454"},{"@type":"CINII_AUTHOR_ID","@value":"DA14647575"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA14647575#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA14647575"},{"@type":"NRID","@value":"9000345272528"},{"@type":"NRID","@value":"9000413751352"},{"@type":"NRID","@value":"9000405895901"},{"@type":"NRID","@value":"9000411815042"},{"@type":"NRID","@value":"9000414826674"},{"@type":"NRID","@value":"9000283664951"},{"@type":"NRID","@value":"9000403042825"},{"@type":"NRID","@value":"9000414334490"},{"@type":"NRID","@value":"9000409611912"},{"@type":"NRID","@value":"9000021518143"},{"@type":"NRID","@value":"9000350642126"},{"@type":"NRID","@value":"9000412253368"},{"@type":"NRID","@value":"9000411100790"},{"@type":"NRID","@value":"9000411100762"},{"@type":"NRID","@value":"9000409764369"},{"@type":"NRID","@value":"9000255803460"},{"@type":"NRID","@value":"9000404672951"},{"@type":"NRID","@value":"9000001816601"},{"@type":"NRID","@value":"9000412590172"},{"@type":"NRID","@value":"9000257906690"},{"@type":"NRID","@value":"9000258624567"},{"@type":"NRID","@value":"9000010322313"},{"@type":"NRID","@value":"9000022094233"},{"@type":"NRID","@value":"9000411802394"},{"@type":"NRID","@value":"9000411952042"},{"@type":"NRID","@value":"9000411117785"},{"@type":"NRID","@value":"9000411013680"},{"@type":"NRID","@value":"9000248241409"},{"@type":"NRID","@value":"9000021618723"},{"@type":"NRID","@value":"9000411211892"},{"@type":"NRID","@value":"9000411118383"},{"@type":"NRID","@value":"9000257905551"},{"@type":"NRID","@value":"9000258620363"},{"@type":"NRID","@value":"9000311062595"},{"@type":"NRID","@value":"9000257907009"},{"@type":"NRID","@value":"9000258623848"},{"@type":"NRID","@value":"9000256494641"},{"@type":"NRID","@value":"9000415428612"},{"@type":"NRID","@value":"9000018204313"},{"@type":"NRID","@value":"9000396113716"},{"@type":"NRID","@value":"9000283422065"},{"@type":"NRID","@value":"9000283423402"},{"@type":"NRID","@value":"9000283422922"},{"@type":"NRID","@value":"9000402394685"},{"@type":"NRID","@value":"9000021033428"},{"@type":"NRID","@value":"9000316209845"},{"@type":"NRID","@value":"9000414494618"},{"@type":"NRID","@value":"9000257906613"},{"@type":"NRID","@value":"9000258620515"},{"@type":"NRID","@value":"9000258626229"},{"@type":"NRID","@value":"9000002008949"},{"@type":"NRID","@value":"9000324993092"},{"@type":"NRID","@value":"9000410462967"},{"@type":"NRID","@value":"9000410014750"},{"@type":"NRID","@value":"9000409764275"},{"@type":"NRID","@value":"9000257911401"},{"@type":"NRID","@value":"9000257907294"},{"@type":"NRID","@value":"9000259335671"},{"@type":"NRID","@value":"9000254449944"},{"@type":"NRID","@value":"9000257905888"},{"@type":"NRID","@value":"9000001217166"},{"@type":"NRID","@value":"9000001498930"},{"@type":"NRID","@value":"9000345289596"},{"@type":"NRID","@value":"9000403159568"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/HidekazuSuzuki1201"}],"foaf:name":[{"@language":"en","@value":"Suzuki Hidekazu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160-8582, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679648652930","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000257905889"}],"foaf:name":[{"@language":"en","@value":"Hibi Toshifumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160-8582, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09120009"},{"@type":"EISSN","@value":"18805086"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Clinical Biochemistry and Nutrition"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ"},{"@language":"en","@value":"J. Clin. Biochem. Nutr."},{"@language":"ja","@value":"Ｊ．　Ｃｌｉｎ．　Ｂｉｏｃｈｅｍ．　Ｎｕｔｒ．"}],"dc:publisher":[{"@language":"en","@value":"SOCIETY FOR FREE RADICAL RESEARCH JAPAN"},{"@language":"ja","@value":"一般社団法人　日本酸化ストレス学会"}],"prism:publicationDate":"2008","prism:volume":"42","prism:number":"2","prism:startingPage":"71","prism:endingPage":"75"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/jcbn/42/2/42_2008012/_pdf"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=gastritis","dc:title":"gastritis"},{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EHelicobacter%20pylori%3C/i%3E","dc:title":"<i>Helicobacter pylori</i>"},{"@id":"https://cir.nii.ac.jp/all?q=vacuolar%20H%3Csup%3E+%3C/sup%3E-ATPase","dc:title":"vacuolar H<sup>+</sup>-ATPase"},{"@id":"https://cir.nii.ac.jp/all?q=osteoclast","dc:title":"osteoclast"},{"@id":"https://cir.nii.ac.jp/all?q=leukocyte","dc:title":"leukocyte"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143655702016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lansoprazole Inhibits Oxygen-Derived Free Radical Production from Neutrophils Activated by Helicobacter pylori"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145106494976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Omeprazole attenuates neutrophil–endothelial cell adhesive interaction induced by extracts of <i>Helicobacter pylori</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618885006336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proton pump inhibitor modifies inflammatory reaction in human gastric mucosa infected by <i>Helicobacter pylori</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093527454592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Treatment with a proton pump inhibitor promotes corpus gastritis in patients with <i>Helicobacter pylori</i>‐infected antrum‐predominant gastritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044100165888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Atrophic Gastritis and<i>Helicobacter pylori</i>Infection in Patients with Reflux Esophagitis Treated with Omeprazole or Fundoplication"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044349597312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Studies Regarding The Mechanism of False Negative Urea Breath Tests With Proton Pump Inhibitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045484710272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sensitivity to vanadate and isoforms of subunits A and B distinguish the osteoclast proton pump from other vacuolar H+ ATPases."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519421790720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>\n                    Infection and the Development of Gastric Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519756679296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>‐eradication therapy decreases the level of neutrophil‐derived oxidants in the ulcerous mucosa of the human stomach: Relationship between ulcer stage and mucosal oxidant level"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521413636096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Omeprazole, a specific inhibitor of H+−K+-ATPase, inhibits bone resorptionin vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994783173504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A vacuolar type H(+)-ATPase regulates cytoplasmic pH in murine macrophages."}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996438198656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470647074304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Selective Inhibition of Osteoclast Vacuolar H+-ATPase"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471254787712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase."}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944730878848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A new mechanism for anti‐inflammatory actions of proton pump inhibitors – inhibitory effects on neutrophil–endothelial cell interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370134355072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843877756928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Omeprazole attenuates oxygen-derived free radical production from human neutrophils"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846209254144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole."}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795424616448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in Children"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269935067136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neutrophil-derived oxidants promote leukocyte adherence in postcapillary venules"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270551916800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A selective inhibitor of the osteoclastic V-H+-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271080627328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271156626816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of omeprazole, an inhibitor of H+, K+-ATPase, on bone resorption in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204672195840","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bile Acids Induce Cdx2 Expression Through the Farnesoid X Receptor in Gastric Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204673396608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lansoprazole-Induced Improvement of Esophageal Submucosal Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204673399424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Immune and Inflammatory Responses in GERD and Lansoprazole"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204673455232","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Progression from Chronic Atrophic Gastritis to Gastric Cancer; Tangle, Toggle, Tackle with Korea Red Ginseng"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204674052096","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Expression of Heme Oxygenase-1 Induced by Lansoprazole"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679599051520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Helicobacter pylori Urease Inhibition by Rabeprazole, a Proton Pump Inhibitor."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679650762496","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-.ALPHA. and Interleukin-1.BETA. Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-.KAPPA.B and Extracellular Signal-Regulated Kinase"},{"@value":"Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-α and Interleukin-1β Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-κB and Extracellular Signal-Regulated Kinase"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0031020192"},{"@type":"CROSSREF","@value":"10.3164/jcbn.2008012"},{"@type":"CIA","@value":"130004466508"},{"@type":"OPENAIRE","@value":"doi_dedup___::02534a0845102a3eccce2006c1635d5c"},{"@type":"CROSSREF","@value":"10.3164/jcbn.10-03_references_DOI_3LwHNTRWNUzgThtTCn0xcaHbIu7"},{"@type":"CROSSREF","@value":"10.3164/jcbn.sr09-28_references_DOI_3LwHNTRWNUzgThtTCn0xcaHbIu7"},{"@type":"CROSSREF","@value":"10.3164/jcbn.08-267_references_DOI_3LwHNTRWNUzgThtTCn0xcaHbIu7"},{"@type":"CROSSREF","@value":"10.3164/jcbn.09-71_references_DOI_3LwHNTRWNUzgThtTCn0xcaHbIu7"}]}