{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679656118528.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4009/jsdt.47.435"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"025725392"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/025725392"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I025725392"}},{"identifier":{"@type":"NAID","@value":"130004679426"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014336873"}}],"dc:title":[{"@language":"ja","@value":"慢性血液透析に導入されたHIV陽性患者9症例の臨床経過と生命予後"},{"@language":"en","@value":"The mortality and clinical course of HIV-infected patients who received chronic hemodialysis treatment"},{"@language":"ja-Kana","@value":"マンセイ ケツエキ トウセキ ニ ドウニュウ サレタ HIV ヨウセイ カンジャ 9 ショウレイ ノ リンショウ ケイカ ト セイメイ ヨゴ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"【Background】 The mortality of HIV-infected patients has been dramatically improved since the highly active anti-retroviral therapy (HAART) era. However, an increase in chronic dialysis patients with HIV has emerged as a new social problem, along with the increasing number of long-term survivors with HIV-infection. The mortality and clinical course of those who have undergone chronic hemodialysis (HD) are not fully understood. 【Subjects and Methods】Clinical characteristics including the status of HIV control, frequency of admission after HD initiation, mean number of days of hospitalization after HD initiation, incidences of cardiac disease, pneumonia, and cancer, and all-cause mortality were retrospectively studied in 9 HIV-infected patients. Cumulative mortality over time following the chronic HD initiation was analyzed by the Kaplan-Meier method. The Kaplan-Meier estimates were compared between HIV patients and 19 age-, gender-, and diabetes comorbidity rate-matched non-HIV CKD patients who initiated chronic HD during the study period. 【Results】Mean patient age was 53.0±8.8 years. Median follow-up period was 4.6 years (range 3.5-8.9 years). All HIV-infected patients had received HAART before the HD initiation. The 5-year cumulative survival rate over time after the HD initiation of the HIV-infected patients was 88.9%, whereas that of the control patients was 79.9% (p=0.4505). Laboratory data of HIV control parameters were well controlled during the maintenance dialysis period. Five cardiac diseases, three bacterial pneumonias, and one oropharynx cancer occurred after the HD initiation. Mean frequency of hospitalization was 2.2±1.4 times and mean number of days of hospitalization was 58.0±51.8. HIV-contaminated needle-stick injury, HIV transmission to medical staff and patients, and trouble due to harmful rumors in dialysis facilities were not reported during the follow-up period. 【Conclusions】The mortality and clinical course of HIV-infected patients after the initiation of chronic HD were better than expected."},{"@language":"ja","@value":"【背景】HIV患者の生命予後は抗HIV薬の多剤併用療法 (HAART) の登場により劇的に改善した. しかし, 長期生存例の増加に伴い, HIV陽性慢性透析患者の出現が新たな社会問題となっている. 本邦には, 慢性血液透析 (HD) に導入されたHIV患者の臨床経過および生命予後を検討した報告はない. 【対象と方法】2004年4月から2013年3月までに, 当院で慢性HDに導入され, サテライト透析施設で外来通院治療が可能であったHIV患者9例を対象とし, 導入後の臨床病像, HIV感染コントロール状態, 主な新規合併症, 入院回数, 延べ入院日数などを2013年9月に電子診療録により調査した. 生命予後をKaplan-Meier曲線にて解析し, 同時期に慢性HDに導入された非HIV患者の中で, 年齢, 性別, 糖尿病合併率をマッチさせた19例を対照として比較した. 【結果】慢性HD導入時の平均年齢は53.0±8.8歳, 観察期間中央値は4.6年 (範囲3.5～8.9年) であった. 全例がHAART治療を継続し, 5年累積生存率は, 88.9％であり, 対照群の79.9％とは有意差を認めなかった. 導入後調査時のHIV感染コントロール状態は良好だった. 新規合併症は心疾患5例 (狭心症+心不全2例, 急性心筋梗塞1例, 狭心症1例, 心不全1例), 細菌性肺炎3例, 中咽頭癌1例を6例の患者に認めた. 導入後の入院回数は平均2.2±1.4回, 延べ入院日数は平均58.0±51.8日だった. 針刺し事故, 他者へのHIV感染事例, 風評被害はなかった. 【結語】HD導入後もHIV感染コントロールの悪化はなく, 生命予後は良好である. 心疾患の新規発症例が多いが, 多くは独歩で外来通院透析を継続できている."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679656118536","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839819"}],"foaf:name":[{"@language":"ja","@value":"原 正樹"},{"@language":"en","@value":"Hara Masaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Renal Division, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院腎臓内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118528","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839820"}],"foaf:name":[{"@language":"ja","@value":"柳澤 如樹"},{"@language":"en","@value":"Yanagisawa Naoki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Infectious Diseases, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院感染症科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118534","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839821"}],"foaf:name":[{"@language":"ja","@value":"能木場 宏彦"},{"@language":"en","@value":"Nokiba Hirohiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Renal Division, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院腎臓内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118531","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839822"}],"foaf:name":[{"@language":"ja","@value":"森戸 卓"},{"@language":"en","@value":"Morito Taku"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Renal Division, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院腎臓内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118533","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839823"}],"foaf:name":[{"@language":"ja","@value":"岩佐 悠子"},{"@language":"en","@value":"Iwasa Yuko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Renal Division, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院腎臓内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118530","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839824"}],"foaf:name":[{"@language":"ja","@value":"菅沼 明彦"},{"@language":"en","@value":"Suganuma Akihiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Infectious Diseases, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院感染症科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118529","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839825"}],"foaf:name":[{"@language":"ja","@value":"今村 顕史"},{"@language":"en","@value":"Imamura Akifumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Infectious Diseases, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院感染症科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118535","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839826"}],"foaf:name":[{"@language":"ja","@value":"味澤 篤"},{"@language":"en","@value":"Ajisawa Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Infectious Diseases, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院感染症科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656118532","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259839827"}],"foaf:name":[{"@language":"ja","@value":"安藤 稔"},{"@language":"en","@value":"Ando Minoru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Renal Division, Department of Medicine, Tokyo Metropolitan Cancer Center and Infectious Disease Center, Komagome Hospital"},{"@language":"ja","@value":"がん・感染症センター都立駒込病院腎臓内科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13403451"},{"@type":"EISSN","@value":"1883082X"},{"@type":"NDL_BIB_ID","@value":"000000091485"},{"@type":"ISSN","@value":"13403451"},{"@type":"LISSN","@value":"13403451"},{"@type":"NCID","@value":"AN10432053"}],"prism:publicationName":[{"@language":"en","@value":"Nihon Toseki Igakkai Zasshi"},{"@language":"ja","@value":"日本透析医学会雑誌"},{"@language":"en","@value":"Nihon Toseki Igakkai Zasshi"},{"@language":"en","@value":"Journal of Japanese Society for Dialysis Therapy"},{"@language":"en","@value":"J. Jpn. Soc. Dial. Ther."},{"@language":"ja","@value":"透析会誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society for Dialysis Therapy"},{"@language":"ja","@value":"一般社団法人 日本透析医学会"}],"prism:publicationDate":"2014","prism:volume":"47","prism:number":"7","prism:startingPage":"435","prism:endingPage":"440"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/025725392"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I025725392"},{"@id":"https://search.jamas.or.jp/link/ui/2014336873"}],"availableAt":"2014","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E7%B4%AF%E7%A9%8D%E7%94%9F%E5%AD%98%E7%8E%87","dc:title":"累積生存率"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%BF%83%E7%96%BE%E6%82%A3","dc:title":"心疾患"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%B4%B0%E8%8F%8C%E6%80%A7%E8%82%BA%E7%82%8E","dc:title":"細菌性肺炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%82%AA%E6%80%A7%E8%85%AB%E7%98%8D","dc:title":"悪性腫瘍"},{"@id":"https://cir.nii.ac.jp/all?q=cumulative%20mortality","dc:title":"cumulative mortality"},{"@id":"https://cir.nii.ac.jp/all?q=cardiac%20disease","dc:title":"cardiac disease"},{"@id":"https://cir.nii.ac.jp/all?q=pneumonia","dc:title":"pneumonia"},{"@id":"https://cir.nii.ac.jp/all?q=cancer","dc:title":"cancer"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292620219740160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Determinants of Survival among HIV-Infected Chronic Dialysis Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093679902848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Africa and Nephrology: The Forgotten Continent"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518396118912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Characteristics of Kidney Disease in Japanese HIV-Infected Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518761321344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"End‐stage renal disease and dialysis in <scp>HIV</scp>‐positive patients: observations from a long‐term cohort study with a follow‐up of 22 years"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993840671360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Is There an Epidemic of HIV Infection in the US ESRD Program?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995667859584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Outcome and Prognosis Factors in HIV-Infected Hemodialysis Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468359262080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical epidemiology of HIV-associated end-stage renal failure in the UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370112949760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changing Trends in the Survival of Dialysis Patients with Human Immunodeficiency Virus in the United States"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268792466688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Survival during Renal Replacement Therapy among African Americans Infected with HIV Type 1 in Urban Baltimore, Maryland"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317027244672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How to manage HIV-infected patients with chronic kidney disease in the HAART era"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1003786639"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I025725392"},{"@type":"CROSSREF","@value":"10.4009/jsdt.47.435"},{"@type":"CIA","@value":"130004679426"}]}