{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679672176128.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1247/csf.18.363"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaK2cXlvFGju7o%3D"}},{"identifier":{"@type":"PMID","@value":"8168160"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/csf1975/18/5/18_5_363/_pdf"}},{"identifier":{"@type":"NAID","@value":"130003512799"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Inhibition of Cell Proliferation by a Unique Lysophosphatidic Acid, PHYLPA, Isolated from Physarum polycephalum: Signaling Events of Antiproliferative Action by PHYLPA."}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The unique <i>Physarum lysophosphatidic</i> acid, PHYLPA, having a cyclopropane in the fatty acid moiety and a cyclic phosphate at C-2 and C-3 positions of the glycerol (16), inhibited proliferation of human fibroblast cells, TIG-3 and TIG-7, which were cultured in a chemically defined (serum-free) medium. The cells at S- and M-phases proceeded to G<sub>2</sub>- and G<sub>1</sub>-phases, respectively, and most of cells were arrested at G<sub>1</sub>- or G<sub>2</sub>- phase during PHYLPA treatment. The growth was recovered when PHYLPA was removed from the medium. In the presence of serum, PHYLPA did not show obvious inhibitory effects, indicating the existence of a factor(s) which neutralizes the antiproliferative activity of PHYLPA.<br> PHYLPA elicited an increase in 3', 5' -cyclic adenosine monophosphate (cAMP) in a biphasic fashion in fibroblast cells. It also elicited inositol phosphate accumulation, as well as a transient rise in cytoplasmic free Ca<sup>2+</sup> ion."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679672176000","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253107317"}],"foaf:name":[{"@language":"en","@value":"Murakami-Murofushi Kimiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biology, Faculty of Science, Ochanomizu University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679672176001","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253107318"}],"foaf:name":[{"@language":"en","@value":"Kaji Kazuhiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tokyo Metropolitan Institute of Gerontology"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679672176130","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253107320"}],"foaf:name":[{"@language":"en","@value":"Fukuda Mitsugu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Tokyo Metropolitan Institute of Gerontology"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679672176002","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253107322"}],"foaf:name":[{"@language":"en","@value":"Murofushi Hiromu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679672176129","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253107319"}],"foaf:name":[{"@language":"en","@value":"Kano Kazutaka"}],"jpcoar:affiliationName":[{"@language":"en","@value":"department of Physiological Chemistry and Nutrition, Faculty of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679672176128","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253107321"}],"foaf:name":[{"@language":"en","@value":"Shioda Masaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"department of Physiological Chemistry and Nutrition, Faculty of Medicine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03867196"},{"@type":"EISSN","@value":"13473700"}],"prism:publicationName":[{"@language":"en","@value":"Cell Structure and Function"},{"@language":"en","@value":"Cell Struct. Funct."}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Cell Biology"},{"@language":"ja","@value":"日本細胞生物学会"}],"prism:publicationDate":"1993","prism:volume":"18","prism:number":"5","prism:startingPage":"363","prism:endingPage":"370"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/csf1975/18/5/18_5_363/_pdf"}],"availableAt":"1993","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Iysophosphatidic%20acid","dc:title":"Iysophosphatidic acid"},{"@id":"https://cir.nii.ac.jp/all?q=cell%20proliferation","dc:title":"cell proliferation"},{"@id":"https://cir.nii.ac.jp/all?q=signaling%20pathway","dc:title":"signaling pathway"},{"@id":"https://cir.nii.ac.jp/all?q=cAMP","dc:title":"cAMP"},{"@id":"https://cir.nii.ac.jp/all?q=(%3Ci%3EPhysarum%20polycephalum%3C/i%3E)","dc:title":"(<i>Physarum polycephalum</i>)"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565165792456320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The effect of cyclic phosphatidic acid on the proliferation and differentiation of mouse cerebellar granule precursor cells during cerebellar development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182070599936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567190194501120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lysophosphatidic Acid Stimulates MCP-1 Secretion from  C2C12 Myoblast"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008021881"},{"@type":"CROSSREF","@value":"10.1247/csf.18.363"},{"@type":"PUBMED","@value":"8168160"},{"@type":"CIA","@value":"130003512799"},{"@type":"OPENAIRE","@value":"doi_dedup___::51e306d3af65824006b97a23cbb3be59"},{"@type":"CROSSREF","@value":"10.5402/2012/983420_references_DOI_88tWqUvE5V13JtJU3HXqLM85frk"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2015.04.013_references_DOI_88tWqUvE5V13JtJU3HXqLM85frk"},{"@type":"CROSSREF","@value":"10.1016/j.ejphar.2014.07.040_references_DOI_88tWqUvE5V13JtJU3HXqLM85frk"}]}