{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679673200384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1247/csf.28.3"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD3sXjtVymsL8%3D"}},{"identifier":{"@type":"PMID","@value":"12655145"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6487134"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6487134"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6487134"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/csf/28/1/28_1_3/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004053827"}},{"identifier":{"@type":"NAID","@value":"50000775056"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2003224368"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"The Role of Apaf-1 in Programmed Cell Death: From Worm to Tumor."},{"@language":"ja-Kana","@value":"Role of Apaf 1 in Programmed Cell Death From Worm to Tumor"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of <i>C. elegans</i>, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistant to various apoptotic stimuli. Apaf-1-mediated apoptosis plays a role in the prevention of tumorigenesis. However, Apaf-1-independent cell death pathways are also indicated. In this review, we will summarize what has been learned about the role of Apaf-1 by biochemical and genetical approaches.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679673200384","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255679471"},{"@type":"NRID","@value":"9000011153818"}],"foaf:name":[{"@language":"en","@value":"Yoshida Hiroshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03867196"},{"@type":"EISSN","@value":"13473700"},{"@type":"NDL_BIB_ID","@value":"000000129749"},{"@type":"ISSN","@value":"03867196"},{"@type":"LISSN","@value":"03867196"},{"@type":"NCID","@value":"AA0060007X"}],"prism:publicationName":[{"@language":"en","@value":"Cell Structure and Function"},{"@language":"en","@value":"Cell Struct. Funct."}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Cell Biology"},{"@language":"ja","@value":"日本細胞生物学会"}],"prism:publicationDate":"2003","prism:volume":"28","prism:number":"1","prism:startingPage":"3","prism:endingPage":"9"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/6487134"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6487134"},{"@id":"http://www.jstage.jst.go.jp/article/csf/28/1/28_1_3/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2003224368"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Apaf-1","dc:title":"Apaf-1"},{"@id":"https://cir.nii.ac.jp/all?q=apoptosis","dc:title":"apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=mitochondria","dc:title":"mitochondria"},{"@id":"https://cir.nii.ac.jp/all?q=caspase","dc:title":"caspase"},{"@id":"https://cir.nii.ac.jp/all?q=cytochrome%20%3Ci%3Ec%3C/i%3E","dc:title":"cytochrome <i>c</i>"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145028013952","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145070802944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145646082176","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Developmental defects and tumor predisposition in Rb mutant mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146108153472","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced 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