{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679706673152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11263/jsotp1982.19.85"}},{"identifier":{"@type":"NAID","@value":"130004040468"}},{"identifier":{"@type":"NAID","@value":"10016241355"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2001081934"}}],"dc:title":[{"@language":"en","@value":"Clinical evaluation of DDS for periodontitis. A comparative literature study."},{"@value":"歯周炎治療用ＤＤＳの臨床評価　　文献による比較検討"}],"dcterms:alternative":[{"@language":"en","@value":"—A comparative literature study—"},{"@value":"―文献による比較検討―"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"As drug information service (DI) in a dental hospital, we evaluated the efficacy and safety of three products of the drug delivery system (DDS) (Periocline<SUP>®</SUP>, Elyzole<SUP>®</SUP>, Perio Chip<SUP>®</SUP>) for treatment of periodontitis, using literature of clinical trials.<BR>Nine literature references (4 for Periocline<SUP>®</SUP>, 4 for Elyzole<SUP>®</SUP>, 1 for Perio Chip<SUP>®</SUP>) were obtained from a MEDLINE database search on the Internet.<BR>The clinical trial design of each reference was a randomized control trial, and three were double blind randomized control trials. The treatment period and examination period were different for each reference. Items of clinical examination included pocket depth (PD), bleeding on probing (BOP), attachment level (AL), plaque index (PI) ; of these, PD was used in all trials.<BR>As for the efficacy of products evaluated by improvement of PD, two references for Periocline<SUP>®</SUP>, and one for Periochnp<SUP>®</SUP>, showed statistically significant improvement, but two references for Elyzole<SUP>®</SUP>, indicated superior improvement of PD in the control group rather than the test group. Only five of the references discussed side effects, but they were mild, transit, local effects."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679706673153","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254947978"},{"@type":"NRID","@value":"9000002511842"}],"foaf:name":[{"@language":"en","@value":"CHIBA TOMOKO"},{"@language":"ja","@value":"千葉 智子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北海道医療大学歯学部附属病院薬剤部"},{"@language":"en","@value":"Department of pharmacy, Dental Hospital, Health Sciences University of Hokkaido"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204277100032","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254947980"},{"@type":"NRID","@value":"9000256106527"},{"@type":"NRID","@value":"9000000807117"},{"@type":"NRID","@value":"9000273749267"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0102563"}],"foaf:name":[{"@language":"en","@value":"SAKATA KUMIKO"},{"@language":"ja","@value":"阪田 久美子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of pharmacy, Dental Hospital, Health Sciences University of Hokkaido"},{"@language":"ja","@value":"北海道医療大学歯学部附属病院薬剤部"},{"@language":"ja","@value":"北海道医療大学薬学部臨床薬剤学教室"},{"@language":"en","@value":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences University of Hokkaido"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679706673154","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254947979"},{"@type":"NRID","@value":"9000001072064"}],"foaf:name":[{"@language":"ja","@value":"小川 隆志"},{"@language":"en","@value":"OGAWA TAKASHI"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of pharmacy, Dental Hospital, Health Sciences University of Hokkaido"},{"@language":"ja","@value":"北海道医療大学歯学部附属病院薬剤部"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679706673152","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254947981"}],"foaf:name":[{"@language":"en","@value":"MIYAZAKI SHOZO"},{"@language":"ja","@value":"宮崎 正三"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences University of Hokkaido"},{"@language":"ja","@value":"北海道医療大学薬学部臨床薬剤学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02881012"},{"@type":"EISSN","@value":"18844928"},{"@type":"NCID","@value":"AN0023517X"}],"prism:publicationName":[{"@language":"en","@value":"ORAL THERAPEUTICS AND PHARMACOLOGY"},{"@language":"ja","@value":"歯科薬物療法"},{"@language":"en","@value":"Shika yakubutsu ryoho"},{"@language":"en","@value":"Oral Therap. Pharmacol."},{"@language":"ja","@value":"歯薬療法"},{"@language":"en","@value":"Oral. Therap. Pharmacol."},{"@language":"ja","@value":"歯科薬物療法"}],"dc:publisher":[{"@language":"en","@value":"JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY"},{"@language":"ja","@value":"日本歯科薬物療法学会"}],"prism:publicationDate":"2000","prism:volume":"19","prism:number":"2","prism:startingPage":"85","prism:endingPage":"94"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2001081934"}],"availableAt":"2000","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=DDS%20for%20treatment%20of%20periodontitis","dc:title":"DDS for treatment of periodontitis"},{"@id":"https://cir.nii.ac.jp/all?q=Periocline%3CSUP%3E%C2%AE%3C/SUP%3E","dc:title":"Periocline<SUP>®</SUP>"},{"@id":"https://cir.nii.ac.jp/all?q=Elyzole%3CSUP%3E%C2%AE%3C/SUP%3E","dc:title":"Elyzole<SUP>®</SUP>"},{"@id":"https://cir.nii.ac.jp/all?q=Perio%20Chip%3CSUP%3E%C2%AE%3C/SUP%3E","dc:title":"Perio Chip<SUP>®</SUP>"},{"@id":"https://cir.nii.ac.jp/all?q=Clinical%20trials","dc:title":"Clinical trials"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%AD%AF%E5%91%A8%E7%82%8E%E6%B2%BB%E7%99%82%E7%94%A8DDS","dc:title":"歯周炎治療用DDS"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9A%E3%83%AA%E3%82%AA%E3%82%AF%E3%83%AA%E3%83%B3","dc:title":"ペリオクリン"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A8%E3%83%AA%E3%82%BE%E3%83%BC%E3%83%AB","dc:title":"エリゾール"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9A%E3%83%AA%E3%82%AA%E3%83%81%E3%83%83%E3%83%97","dc:title":"ペリオチップ"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%87%A8%E5%BA%8A%E8%A9%A6%E9%A8%93","dc:title":"臨床試験"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144613050624","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795734017664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the long‐term efficacy and safety of locally‐applied minocycline in adult periodontitis patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204411940864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Minocycline HCl concentration in periodontal pocket after administration of LS-007."},{"@value":"ＬＳ‐００７投与後の歯周ポケット内ミノサイクリン濃度"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679388649984","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Periodontal therapy by local delivery of minocycline. Clinical study on optimum concentration of in LS-007."},{"@value":"ミノサイクリンの局所的応用による歯周病治療法　　ＬＳ‐００７至適濃度の臨床的検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225710303872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"変容する歯周治療法の現在"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226453436544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Periodontal therapy by local delibery of tetracycline"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291226735205120","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sustained-release delivery systems for treatment of dental diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700274824064","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"ミノサイクリンの局所的応用による歯周病治療法"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700274826368","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"ミノサイクリンの局所的応用による歯周病治療法, 軟膏基剤との二重盲検比較試験"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700274827648","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Local and systemic chemotherapy in the macagement of periodontao disease- an opinion and review of the concept"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700274828928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A randomized controlled trial of a 2% minocycline gel as an adjunct to non-surgical periodontal treatment, using a design with multiple matching criteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175251540864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"歯周治療における抗菌剤の利用"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135650228248192","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075158377216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"3 reginens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075158380416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980075158382976","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sustained local delivery of chlorhexidine in the treatment of periodontitis, A multi-center study"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980076620232704","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1572261551290471552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Topical metronidazole application compared with subgingival scaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025111800064","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The development and in vitro evaluation of acrylic strips and dialysis tubing for local deligery"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025111802240","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontal disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025111803392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"歯周治療における局所化学療法"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501520136832","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The mandibular alveolar ridge extension method using a surgical splint with porous hydroxyapatite (HAP) particles"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450041933312","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Improved clinical decision-making using the evidence-based approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231876445222144","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"英国における Drug Delivery System の開発の動向 (その2)"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008909021"},{"@type":"CIA","@value":"130004040468"},{"@type":"CIA","@value":"10016241355"}]}