{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679711281024.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11263/jsotp.31.13"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BC38XhtFSrsbfL"}},{"identifier":{"@type":"URI","@value":"https://petit.lib.yamaguchi-u.ac.jp/19751"}},{"identifier":{"@type":"NAID","@value":"10031168915"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2012235909"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Comparative study of subacute toxicity in anti-inflammatory drug, Presteron and steroidal anti-inflammatory drug, dexamethasone"},{"@language":"ja","@value":"抗炎症薬プレステロンとステロイド系抗炎症薬デキサメタゾンの亜急性毒性比較試験"},{"@language":"ja-Kana","@value":"コウエンショウヤク プレステロン ト ステロイドケイ コウエンショウヤク デキサメタゾン ノ アキュウセイ ドクセイ ヒカク シケン"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Presteron (PS) is an anti-inflammatory drug. It was reported that PS had no side effects like steroids on oral administration and intramuscular injection in human. The purpose of this study was to compare the subacute toxicity of PS with a general steroidal anti-inflammatory drug, dexamethasone (Dex) in rat.<br>21 male Wistar rats were divided into three groups with 7 rats in each. The rats were injected subcutaneously for 14 days in each 0.1mL/100g body weight/day with: a control solution (saline contained CMC and Tween20), CT group; a control solution containing 16mg/mL PS, PS group; a control solution containing 0.1mg/mL Dex, Dex group.<br>CT group and PS group showed no difference in behavior and body weight of rats, but Dex group revealed significantly marked suppression of increasing body weight. In blood test Dex group showed significant increase of erythrocyte, hemoglobin, hematocrit. In histological Dex group was demonstrated markedly degenerative changes, but no marked change was observed with PS group.<br>It was indicated that Dex yields the typical steroidal side effects such as marked atrophy in adrenal gland, spleen and thymus. On the other hand, it was concluded that PS systemically exhibits no adverse effect like steroids on administration of about 20-fold clinical dose for 14 days."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410853647124809731","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259330534"}],"foaf:name":[{"@language":"en","@value":"TOMURA JUNJI"},{"@language":"ja","@value":"戸村 淳嗣"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Nippon Shika Yakuhin Co., Ltd."},{"@language":"ja","@value":"日本歯科薬品株式会社"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326225710848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90205914"},{"@type":"NRID","@value":"1000090205914"},{"@type":"NRID","@value":"9000259330535"},{"@type":"NRID","@value":"9000345269550"},{"@type":"NRID","@value":"9000397814452"},{"@type":"NRID","@value":"9000002065608"},{"@type":"NRID","@value":"9000025042066"},{"@type":"NRID","@value":"9000411384477"},{"@type":"NRID","@value":"9000405365241"},{"@type":"NRID","@value":"9000265246599"},{"@type":"NRID","@value":"9000021953025"},{"@type":"NRID","@value":"9000021953006"},{"@type":"NRID","@value":"9000257759483"},{"@type":"NRID","@value":"9000020941698"},{"@type":"NRID","@value":"9000311503909"},{"@type":"NRID","@value":"9000240042179"},{"@type":"NRID","@value":"9000404666407"},{"@type":"NRID","@value":"9000020620735"},{"@type":"NRID","@value":"9000022059495"},{"@type":"NRID","@value":"9000414259801"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0207071"}],"foaf:name":[{"@language":"en","@value":"SATO KOICHI"},{"@language":"ja","@value":"佐藤 晃一"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"山口大学農学部獣医学科生体機能学講座獣医薬理学"},{"@language":"en","@value":"Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658408845312","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30274187"},{"@type":"NRID","@value":"1000030274187"},{"@type":"NRID","@value":"9000005512437"},{"@type":"NRID","@value":"9000259330536"},{"@type":"NRID","@value":"9000020625161"},{"@type":"NRID","@value":"9000020841765"},{"@type":"NRID","@value":"9000256186385"},{"@type":"NRID","@value":"9000321623175"},{"@type":"NRID","@value":"9000402820508"},{"@type":"NRID","@value":"9000254980845"},{"@type":"NRID","@value":"9000020857979"},{"@type":"NRID","@value":"9000321624300"},{"@type":"NRID","@value":"9000321623151"},{"@type":"NRID","@value":"9000009620159"},{"@type":"NRID","@value":"9000321624148"},{"@type":"NRID","@value":"9000321623215"},{"@type":"NRID","@value":"9000321624274"},{"@type":"NRID","@value":"9000321624395"},{"@type":"NRID","@value":"9000399368596"},{"@type":"NRID","@value":"9000399379656"},{"@type":"NRID","@value":"9000254429501"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0185157"}],"foaf:name":[{"@language":"en","@value":"MORIMOTO MASAHIRO"},{"@language":"ja","@value":"森本 將弘"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University"},{"@language":"ja","@value":"山口大学農学部獣医学科病態制御学講座獣医病理学"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282680164797699","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014618724"},{"@type":"NRID","@value":"9000383071618"},{"@type":"NRID","@value":"9000375898199"}],"foaf:name":[{"@language":"en","@value":"TSUNEKAWA MASAYOSHI"},{"@language":"ja","@value":"常川 勝由"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Nippon Shika Yakuhin Co., Ltd."},{"@language":"ja","@value":"日本歯科薬品株式会社"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02881012"},{"@type":"EISSN","@value":"18844928"},{"@type":"NCID","@value":"AN0023517X"}],"prism:publicationName":[{"@language":"en","@value":"ORAL THERAPEUTICS AND PHARMACOLOGY"},{"@language":"ja","@value":"歯科薬物療法"},{"@language":"en","@value":"Shika yakubutsu ryoho"},{"@language":"en","@value":"Oral Therap. Pharmacol."},{"@language":"ja","@value":"歯薬療法"},{"@language":"en","@value":"Oral. Therap. Pharmacol."},{"@language":"ja","@value":"歯科薬物療法"}],"dc:publisher":[{"@language":"en","@value":"JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY"},{"@language":"ja","@value":"日本歯科薬物療法学会"}],"prism:publicationDate":"2012","prism:volume":"31","prism:number":"1","prism:startingPage":"13","prism:endingPage":"20"},"dcterms:accessRights":"http://purl.org/coar/access_right/c_14cb","url":[{"@id":"https://petit.lib.yamaguchi-u.ac.jp/19751"},{"@id":"https://search.jamas.or.jp/link/ui/2012235909"}],"availableAt":"2012","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=presteron%20(epidihydrocholesterin)","dc:title":"presteron (epidihydrocholesterin)"},{"@id":"https://cir.nii.ac.jp/all?q=anti-inflammatory%20drug","dc:title":"anti-inflammatory drug"},{"@id":"https://cir.nii.ac.jp/all?q=dexamethasone","dc:title":"dexamethasone"},{"@id":"https://cir.nii.ac.jp/all?q=subacute%20toxicity","dc:title":"subacute toxicity"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%97%E3%83%AC%E3%82%B9%E3%83%86%E3%83%AD%E3%83%B3%EF%BC%8C%E3%82%A8%E3%83%94%E3%82%B8%E3%83%92%E3%83%89%E3%83%AD%E3%82%B3%E3%83%AC%E3%82%B9%E3%83%86%E3%83%AA%E3%83%B3","dc:title":"プレステロン，エピジヒドロコレステリン"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%8A%97%E7%82%8E%E7%97%87%E8%96%AC","dc:title":"抗炎症薬"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%87%E3%82%AD%E3%82%B5%E3%83%A1%E3%82%BF%E3%82%BE%E3%83%B3","dc:title":"デキサメタゾン"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%BA%9C%E6%80%A5%E6%80%A7%E6%AF%92%E6%80%A7%E8%A9%A6%E9%A8%93","dc:title":"亜急性毒性試験"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@value":"presteron (epidihydrocholesterin)"}]},{"subjectScheme":"Other","notation":[{"@value":"プレステロン, エピジヒドロコレステリン"}]},{"subjectScheme":"Other","notation":[{"@value":"anti-inflammatory drug"}]},{"subjectScheme":"Other","notation":[{"@value":"抗炎症薬"}]},{"subjectScheme":"Other","notation":[{"@value":"dexamethasone"}]},{"subjectScheme":"Other","notation":[{"@value":"デキサメタゾン"}]},{"subjectScheme":"Other","notation":[{"@value":"subacute toxicity"}]},{"subjectScheme":"Other","notation":[{"@value":"亜急性毒性試験"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1060307889704340736","@type":"Product","relationType":["isVersionOf"]},{"@id":"https://cir.nii.ac.jp/crid/1390001205153938688","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"鉄ウィスカーにおよぼす中性子照射の影響"},{"@language":"en","@value":"Irradiation Effects in Iron Whisker"},{"@language":"ja-Kana","@value":"テツ ウィスカー ニ オヨボス チュウセイシ ショウシャ ノ エイキョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1520572358024028416","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Steroidの鎮痛作用に関する研究-1-"},{"@language":"ja-Kana","@value":"Steroid ノ チンツウ サヨウ ニ カンスル ケンキュウ 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センタクシ"}]},{"@id":"https://cir.nii.ac.jp/crid/1523669554791642496","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"内科領域におけるプレステロンの臨床効果"},{"@language":"ja-Kana","@value":"ナイカ リョウイキ ニ オケル プレステロン ノ リンショウ コウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1523951029797172864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Epidihydrocholesterol-Pasteの抜歯窩使用に際しての治癒成績について"},{"@language":"ja-Kana","@value":"Epidihydrocholesterol-Paste ノ バッシカシヨウ ニ サイシテ ノ チユ セイセキ ニ ツイテ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225553721216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"歯周組織炎治療薬TCPS軟膏に関する研究 : 歯髄細胞でのアラキドン酸とその代謝産物の遊離に対する抗炎症薬プレステロンの効果"},{"@language":"en","@value":"Studies on anti-periodontitis ointment TCPS (Tetracycline Presteron) paste : effect of presteron on the release of arachidonic acid and its metabolites in rat clonal dental pulp cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699355977984","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"歯槽膿漏症の治療薬「T.c-プレステロン軟膏」の臨床成績"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699355980544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Fluorometholone の亜急性毒性試験-ラットにおける Dexamethasone との比較試験"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854174332690816","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Epidihydrocholesterin の毒性に関する研究 (第3報)-ラットにおける経口投与による亜急性毒性試験-"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176091995392","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"新しい歯周炎治療薬「テトラサイクリン・プレステロン歯科用軟膏 (TCPSカートリッジ)」の臨床経験"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599262815488","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"歯肉炎に対する T.C Presteron 軟膏 (科薬抗生物質研究所製) の臨床効果について"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074239525760","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Epidihydrocholesterin の毒性に関する研究 (第2報)-ラットにおける腹腔内投与による亜急性毒性試験-"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549216237568","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"TC Presteron 軟膏の使用成績について"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924099790720","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Epidihydrocholesterin の化膿性疾患に対する抵抗性に就いて"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924099797248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"急性化膿性智歯周囲炎に対する T.C Presteron 軟膏の使用成績について"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399076503552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Epidihydrocholesterin 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