{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679749396480.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11289/otoljpn.24.760"}},{"identifier":{"@type":"NAID","@value":"130005165995"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2015152043"}}],"dc:title":[{"@language":"ja","@value":"難治性中耳炎症状を呈するANCA陽性症例の疫学調査と診断基準の問題点に関する検討"},{"@language":"en","@value":"Epidemiological study of ANCA-positive patients with refractory otitis media-like symptoms and implications for diagnosis of on MPO-ANCA-associated refractory otitis media"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"It was reported that among the patients who complained of refractory otitis media-like symptoms, some had anti-neutrophil cytoplasmic autoantibodies (ANCA) in the serum, but did not meet the criteria of ANCA-associated vasculites such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA).  Most of them showed a positive MPO-ANCA, but not PR3-ANCA in the serum with no pulmonary and renal lesions.  Subsequently, these patients often suffered from sensorineural hearing loss and facial palsy.  In 2011, we proposed the diagnostic term and criteria of MPO-ANCA-associated middle ear disease with sensorineural hearing loss and facial palsy (MPO-ANCA-associated middle ear disease).  In the present epidemiological study, we examined 17 ANCA-positive patients with refractory otitis media-like symptoms from 25 affiliated hospitals.  The diagnosis of GPA was given to 11 patients, while 6 patients were diagnosed as MPO-ANCA-associated middle ear disease.  In the latter group of 6 patients, however, the diagnosis GPA was warranted on the basis of a positive MPO-ANCA in the serum.  Indeed, it was reported that some patients with GPA that was diagnosed histopathologically, showed a positive MPO-ANCA in the serum.  Therefore, the present study suggests that MPO-ANCA-associated middle ear disease should be classified as a subtype of GPA despite the lack of histopathological evidence of vasculitis."},{"@language":"ja","@value":"近年、難治性中耳炎症状を呈するANCA陽性症例の報告が増加している。これらの症例の中には、ANCA関連血管炎であるGPA、MPA、EGPAの診断基準を満たさず、2011年に我々が提唱した感音難聴と顔面神経麻痺を示すMPO-ANCA関連中耳疾患 (以下、MPO-ANCA関連中耳疾患) が含まれる。<br>今回我々は、難治性の中耳炎症状を呈するANCA陽性症例において、MPO-ANCA関連中耳疾患とANCA関連血管炎であるGPA、MPA、EGPAとの関係を明らかにする目的で、近畿と四国の関連病院25施設にアンケート調査を行い、17例の回答を得た。この17例は、診断基準に基づいてGPAとMPO-ANCA関連中耳疾患の2疾患に診断できた。さらに、仮にGPAの診断基準にMPO-ANCA陽性を追加すると、全例がGPAと診断できることが分った。全身型GPAにはMPO-ANCA陽性の症例も存在することから、難治性の中耳炎症状を呈するMPO-ANCA陽性でPR3-ANCA陰性のMPO-ANCA関連中耳疾患は、病理組織検査では血管炎の所見が得られないものの、疫学研究結果からは限局型GPAに含まれると考えられた。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658324094208","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30206982"},{"@type":"NRID","@value":"1000030206982"},{"@type":"NDL_AUTHOR_ID","@value":"00731774"},{"@type":"NRID","@value":"9000003195677"},{"@type":"NRID","@value":"9000398801022"},{"@type":"NRID","@value":"9000410657705"},{"@type":"NRID","@value":"9000255943222"},{"@type":"NRID","@value":"9000249260117"},{"@type":"NRID","@value":"9000415416157"},{"@type":"NRID","@value":"9000415417438"},{"@type":"NRID","@value":"9000311063119"},{"@type":"NRID","@value":"9000253267609"},{"@type":"NRID","@value":"9000283281489"},{"@type":"NRID","@value":"9000018750558"},{"@type":"NRID","@value":"9000280535167"},{"@type":"NRID","@value":"9000004888992"},{"@type":"NRID","@value":"9000311063245"},{"@type":"NRID","@value":"9000347134323"},{"@type":"NRID","@value":"9000325828354"},{"@type":"NRID","@value":"9000413900865"},{"@type":"NRID","@value":"9000413337611"},{"@type":"NRID","@value":"9000000448975"},{"@type":"NRID","@value":"9000398605436"},{"@type":"NRID","@value":"9000321625855"},{"@type":"NRID","@value":"9000412194329"},{"@type":"NRID","@value":"9000404787284"},{"@type":"NRID","@value":"9000415416200"},{"@type":"NRID","@value":"9000364827847"},{"@type":"NRID","@value":"9000404089150"},{"@type":"NRID","@value":"9000367021438"},{"@type":"NRID","@value":"9000415416176"},{"@type":"NRID","@value":"9000292185292"},{"@type":"NRID","@value":"9000283315202"},{"@type":"NRID","@value":"9000370764931"},{"@type":"NRID","@value":"9000345349963"},{"@type":"NRID","@value":"9000305637535"},{"@type":"NRID","@value":"9000254465287"},{"@type":"NRID","@value":"9000283315125"},{"@type":"NRID","@value":"9000345302105"},{"@type":"NRID","@value":"9000345302282"},{"@type":"NRID","@value":"9000398302586"},{"@type":"NRID","@value":"9000273003518"},{"@type":"NRID","@value":"9000415417451"},{"@type":"NRID","@value":"9000412185509"},{"@type":"NRID","@value":"9000412234232"},{"@type":"NRID","@value":"9000370764754"},{"@type":"NRID","@value":"9000375901151"},{"@type":"NRID","@value":"9000398278846"},{"@type":"NRID","@value":"9000258258804"},{"@type":"NRID","@value":"9000257690917"},{"@type":"NRID","@value":"9000361693565"},{"@type":"NRID","@value":"9000399773424"},{"@type":"NRID","@value":"9000370764917"},{"@type":"NRID","@value":"9000316692237"},{"@type":"NRID","@value":"9000305637507"},{"@type":"NRID","@value":"9000410657717"},{"@type":"NRID","@value":"9000415417414"},{"@type":"NRID","@value":"9000345302108"},{"@type":"NRID","@value":"9000345230324"},{"@type":"NRID","@value":"9000408919295"},{"@type":"NRID","@value":"9000283281746"},{"@type":"NRID","@value":"9000257947997"},{"@type":"NRID","@value":"9000399773416"},{"@type":"NRID","@value":"9000408919264"},{"@type":"NRID","@value":"9000415416404"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0013690"}],"foaf:name":[{"@language":"ja","@value":"武田 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秀典"},{"@language":"en","@value":"Inohara Hidenori"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otolaryngology, Osaka University Medical School"},{"@language":"ja","@value":"大阪大学耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751163973888","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60380028"},{"@type":"NRID","@value":"1000060380028"},{"@type":"NRID","@value":"9000003770100"},{"@type":"NRID","@value":"9000410657714"},{"@type":"NRID","@value":"9000257948549"},{"@type":"NRID","@value":"9000020926445"},{"@type":"NRID","@value":"9000311063117"},{"@type":"NRID","@value":"9000283281486"},{"@type":"NRID","@value":"9000258225930"},{"@type":"NRID","@value":"9000311063242"},{"@type":"NRID","@value":"9000413900873"},{"@type":"NRID","@value":"9000283104863"},{"@type":"NRID","@value":"9000261039186"},{"@type":"NRID","@value":"9000404787283"},{"@type":"NRID","@value":"9000399542436"},{"@type":"NRID","@value":"9000292183068"},{"@type":"NRID","@value":"9000283315201"},{"@type":"NRID","@value":"9000021554244"},{"@type":"NRID","@value":"9000243896246"},{"@type":"NRID","@value":"9000398302593"},{"@type":"NRID","@value":"9000412185508"},{"@type":"NRID","@value":"9000329015030"},{"@type":"NRID","@value":"9000412234239"},{"@type":"NRID","@value":"9000399773423"},{"@type":"NRID","@value":"9000410657715"},{"@type":"NRID","@value":"9000415417406"},{"@type":"NRID","@value":"9000370764773"},{"@type":"NRID","@value":"9000408919303"},{"@type":"NRID","@value":"9000257947990"},{"@type":"NRID","@value":"9000399773415"},{"@type":"NRID","@value":"9000292185287"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ykitamura1212"}],"foaf:name":[{"@language":"ja","@value":"北村 嘉章"},{"@language":"en","@value":"Kitamura Yoshiaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otolaryngology, Unoversity of Tokushima School of Medicine"},{"@language":"ja","@value":"徳島大学耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679749396486","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000329015031"}],"foaf:name":[{"@language":"ja","@value":"阿部 晃治"},{"@language":"en","@value":"Abe Koji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otolaryngology, Unoversity of Tokushima School of Medicine"},{"@language":"ja","@value":"徳島大学耳鼻咽喉科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09172025"},{"@type":"EISSN","@value":"18841457"}],"prism:publicationName":[{"@language":"en","@value":"Otology Japan"},{"@language":"ja","@value":"Ｏｔｏｌｏｇｙ　Ｊａｐａｎ"},{"@language":"en","@value":"Otol Jpn"},{"@language":"ja","@value":"Ｏｔｏｌ　Ｊｐｎ"}],"dc:publisher":[{"@language":"en","@value":"Japan Otological Society"},{"@language":"ja","@value":"一般社団法人　日本耳科学会"}],"prism:publicationDate":"2014","prism:volume":"24","prism:number":"5","prism:startingPage":"760","prism:endingPage":"765"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2015152043"}],"availableAt":"2014","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E9%9B%A3%E6%B2%BB%E6%80%A7%E4%B8%AD%E8%80%B3%E7%82%8E","dc:title":"難治性中耳炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%84%9F%E9%9F%B3%E9%9B%A3%E8%81%B4","dc:title":"感音難聴"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%A1%94%E9%9D%A2%E7%A5%9E%E7%B5%8C%E9%BA%BB%E7%97%BA","dc:title":"顔面神経麻痺"},{"@id":"https://cir.nii.ac.jp/all?q=MPO-ANCA%E9%96%A2%E9%80%A3%E4%B8%AD%E8%80%B3%E7%96%BE%E6%82%A3","dc:title":"MPO-ANCA関連中耳疾患"},{"@id":"https://cir.nii.ac.jp/all?q=ANCA%E9%96%A2%E9%80%A3%E8%A1%80%E7%AE%A1%E7%82%8E%E6%80%A7%E4%B8%AD%E8%80%B3%E7%82%8E","dc:title":"ANCA関連血管炎性中耳炎"},{"@id":"https://cir.nii.ac.jp/all?q=MPO-ANCA-associated%20vasculitis","dc:title":"MPO-ANCA-associated vasculitis"},{"@id":"https://cir.nii.ac.jp/all?q=Wegener's%20glanulomatosis","dc:title":"Wegener's glanulomatosis"},{"@id":"https://cir.nii.ac.jp/all?q=granulomatosis%20with%20polyangiitis","dc:title":"granulomatosis with polyangiitis"},{"@id":"https://cir.nii.ac.jp/all?q=MPO-ANCA-associated%20middle%20ear%20disease","dc:title":"MPO-ANCA-associated middle ear disease"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2001055411"},{"@type":"CIA","@value":"130005165995"}]}