{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679753841024.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5649/jjphcs.27.5"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10557649"}},{"identifier":{"@type":"NAID","@value":"110001166485"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/digimeta/10557649"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/10557649"}},{"identifier":{"@type":"URI","@value":"http://dl.ndl.go.jp/info:ndljp/pid/10557649"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2001240244"}}],"dc:title":[{"@language":"en","@value":"A Study on Drug-Induced Hypersensitivity Hepatic Injury by Leucocyte Migration Test"},{"@value":"白血球遊走試験による薬剤過敏性肝障害の検討"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"The identification of allergenic drugs was performed in 79 patients suspected of suffering from drug-induced hepatic injury using the leucocyte migration test (LMT). Moreover, the LMT was performed on the administered drugs in 35 patients who had been receiving drugs but had not yet manifested any allergic symptoms (patients without hypersensitivity to drugs). If either leucocyte migration activating factor (LMAF) or leucocyte migration inhibitory factor (LMIF) was detected in the LMT either with or without the patient's serum, then the test results were regarded as positive. <BR>The proportion of LMT positives was 67.1% in 79 patients suspected of suffering drug-induced hepatic injury and 8.6% in 35 patients without any such hypersensitivity to the drugs, and therefore the positive rate was significantly higher in the patients suspected of suffering drug-induced hepatic injury than in the patients without hypersensitivity to the drugs (p<0.0001, X<SUP>2</SUP>-test). The proportion of LMT positives was 45.6% for tests with the patient's serum and 46.8% for tests without the patient' s serum, and there was no substantial difference in the LMT-positive rate between both tests. In addition, no substantial difference was observed among the four clinical types of hepatic injuries. In addition, LMAF was detected in 34.2% and LMIF in 38.0%, and no substantial difference was seen in the rate of detection between both factors. However, concomitant symptoms were observed in 34 cases (43.0%). The proportion of LMT positives was 82.4% in the cases with concomitant symptoms and 55.6% in those without concomitant symptoms. Accordingly, the proportion of LMT positives were significantly higher in the cases with concomitant symptoms than in those without concomitant symptoms (p<0.05, X<SUP>2</SUP>-test). LMT-positive drugs were detected in 57 cases, in which 38.6% were β-lactam antibiotics and 17.5% were non-steroidal antiinflammatory drugs. LMAF was more frequently detected in patients with β-lactam antibiotic-induced hepatic injury (p<0.01, X<SUP>2</SUP>-test), while LMIF was detected more frequently in the patients with non-steroidal antiinflammatory drug-induced hepatic injury (p<0.01, X<SUP>2</SUP>-test). The latent period from the start of drug administration to the onset of hepatic injury was 6.3 days in the patients with β-lactam antibiotic-induced hepatic injury but 33.7 days in those with hepatic injury induced by central nervous system drugs, except for non-steroidal antiinflammatory drugs (p<0.05, t-test).<BR>Our findings indicate that the LMT is a valuable method for identifying allergenic drugs in drug-induced hypersensitivity hepatic injury, while cell-mediated immunity was shown to be closely involved in the pathogenesis of hepatic injury with concomitant symptoms and the patient's serum may thus play little role in the pathogenesis of drug-induced hepatic injury. Furthermore, the pathogenic mechanism of β-lactam antibiotic-induced hepatic injury was also found to possibly be different from that of non-steroidal antiinflammatory drug-induced hepatic injury. The latent period from the start of drug administration up until the onset of β-lactam antibiotic-induced hepatic injury may be shorter than that of hepatic injury induced by central nervous system drugs, except for non-steroidal antiinflammatory drugs."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410572171252501888","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Abe Manabu"},{"@language":"ja","@value":"阿部 学"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacy, Suibarago Hospital"},{"@language":"ja","@value":"水原郷病院薬剤科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410572171252501889","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000363364573"}],"foaf:name":[{"@language":"en","@value":"Uno Katsuji"},{"@language":"ja","@value":"宇野 勝次"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacy, Suibarago Hospital"},{"@language":"ja","@value":"水原郷病院薬剤科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1346342X"},{"@type":"LISSN","@value":"1346342X"},{"@type":"EISSN","@value":"18821499"},{"@type":"NCID","@value":"AA11527197"}],"prism:publicationName":[{"@language":"en","@value":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)"},{"@language":"ja","@value":"医療薬学"},{"@language":"en","@value":"Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)"},{"@language":"en","@value":"JJPHCS"},{"@language":"en","@value":"Jpn. J. Pharm. Health Care Sci."},{"@language":"ja","@value":"医療薬学"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Pharmaceutical Health Care and Sciences"},{"@language":"ja","@value":"一般社団法人日本医療薬学会"}],"prism:publicationDate":"2001","prism:volume":"27","prism:number":"1","prism:startingPage":"5","prism:endingPage":"14"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/digimeta/10557649"},{"@id":"https://dl.ndl.go.jp/pid/10557649"},{"@id":"http://dl.ndl.go.jp/info:ndljp/pid/10557649"},{"@id":"https://search.jamas.or.jp/link/ui/2001240244"}],"availableAt":"2001","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=drug-induced%20hepatic%20injury","dc:title":"drug-induced hepatic injury"},{"@id":"https://cir.nii.ac.jp/all?q=allergenic%20drug","dc:title":"allergenic drug"},{"@id":"https://cir.nii.ac.jp/all?q=leucocyte%20migration%20test","dc:title":"leucocyte migration test"},{"@id":"https://cir.nii.ac.jp/all?q=leucocyte%20migration%20activating%20factor","dc:title":"leucocyte migration activating factor"},{"@id":"https://cir.nii.ac.jp/all?q=leucocyte%20migration%20inhibitory%20factor","dc:title":"leucocyte migration inhibitory factor"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292619065356544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Modulation of Suppressor Mechanisms in Allergic Contact Dermatitis: 1. Effect of C. parvum on the Induction Phase of Contact Allergy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045502772736","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"An Overview of Current Cytochrome P450 Technology for Assessing the Safety and Efficacy of New Materials"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996414721408","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Application of leucocyte migration tests to detection of allergenic drugs in patients with hypersensitivity to <i>β</i>-lactam antibiotics"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204625749120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative Study of the Usefulness of the Drug-Induced Lymphocyte Stimulation Test and the Leukocyte Migration Test in Drug Allergies"},{"@value":"Comparative study of usefulness of the drug-induced lymphocyte stimulation test and the leukocyte migration test in drug allergies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204775695232","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Study on Itching in Allergic Drug Eruption"},{"@language":"ja","@value":"アレルギー性薬疹における掻痒感の検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204790543616","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"薬剤アレルギー性肝障害におけるリンパ球刺激試験，マクロファージ遊走阻止試験，白血球遊走阻止試験の比較検討"},{"@language":"en","@value":"Studies of LST, MIT and LIT in drug-induced hepatic injury"},{"@language":"ja-Kana","@value":"ヤクザイ アレルギーセイ カン ショウガイ ニ オケル リンパキュウ シゲキ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204977086848","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"免疫・アレルギーと老化"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204980701824","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"気管支喘息患者リンパ球に対するデキサメサゾンのアポトーシス誘導"},{"@language":"en","@value":"DEXAMETHASONE-INDUCED APOPTOSIS IN PERIPHERAL T LYMPHOCYTES FROM PATIENTS WITH ASTHMA"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679610157184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Study of Elevated Interleukin-8 (CXCL8) and Detection of Leukocyte Migration Inhibitory Activity in Patients Allergic to Beta-Lactam Antibiotics"},{"@value":"A Study of Elevated Interleukin-8 (CXCL8) Detection of Leukocyte Migration Inhibitory Activity in Patients Allergic to Beta-Lactam Antibiotics"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679751412224","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Study on Drug-Induced Hypersensitivity Blood Disorders Using Leukocyte Migration Test"},{"@value":"白血球遊走試験による薬剤過敏性血液障害の検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679752583040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Analysis of Drug Allergies to Detect Causative Drugs and Determine Other Aspects of Their Pathogenic Mechanisms"},{"@language":"ja","@value":"薬剤アレルギーの起因薬検出,臨床解析および発現機構に関する研究"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679754237952","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"薬物アレルギー起因薬検出における白血球遊走試験 (ケモタキシス·チャンバー法)の臨床的有用性の検討"},{"@language":"en","@value":"Study on Clinical Usefulness of Chemotaxis Chamber Method in Leukocyte Migration Test for Identification of Allergenic 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