{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679754600960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5649/jjphcs1975.19.80"}},{"identifier":{"@type":"NAID","@value":"130004103100"}}],"dc:title":[{"@language":"en","@value":"Quantitative Analysis of Emetine and Cephaeline in Ipecac Syrup."},{"@value":"トコンシロップ中のエメチン，セファエリンの定量法について"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We established an easy and quick determination method of emetine (EM) and cephaeline (CP) in ipecac syrup by HPLC, which was carried out by using chloroquine as an internal standard. The calibration plots of these alkaloids showed a good linearity. Semi-preparative HPLC followed by mass-spectrometry was employed and the spectra of EM and CP isolated by preparative HPLC were found to be identical with those of authentic samples. Constant amounts of EM and CP were added to samples and the recovery rates were determined. This method gave a good recovery. The total contents of EM and CP in ipecac syrup from the USA ranged 153.2-184.9 mg/ 100ml and the content ratios (CP/ EM) were 2.6-3.0. These levels were higher than those of the USP standard for ipecac syrup."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679754600961","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255839957"}],"foaf:name":[{"@language":"en","@value":"TESHIMA DAISUKE"},{"@language":"ja","@value":"手嶋 大輔"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University"},{"@language":"ja","@value":"九州大学医学部附属病院薬剤部"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679754600960","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000255839958"}],"foaf:name":[{"@language":"en","@value":"AOYAMA TOSHINOBU"},{"@language":"ja","@value":"青山 敏信"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University"},{"@language":"ja","@value":"九州大学医学部附属病院薬剤部"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03899098"},{"@type":"EISSN","@value":"21859477"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Hospital Pharmacy"},{"@language":"ja","@value":"病院薬学"},{"@language":"en","@value":"Japanese Journal of Hospital Pharmacy"},{"@language":"ja","@value":"病院薬学"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Pharmaceutical Health Care and Sciences"},{"@language":"ja","@value":"一般社団法人 日本医療薬学会"}],"prism:publicationDate":"1993","prism:volume":"19","prism:number":"1","prism:startingPage":"80","prism:endingPage":"83"},"reviewed":"false","availableAt":"1993","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=ipecac%20syrup","dc:title":"ipecac syrup"},{"@id":"https://cir.nii.ac.jp/all?q=emetine","dc:title":"emetine"},{"@id":"https://cir.nii.ac.jp/all?q=cephaeline","dc:title":"cephaeline"},{"@id":"https://cir.nii.ac.jp/all?q=high%20performance%20liquid%20chromatography","dc:title":"high performance liquid chromatography"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0007946664"},{"@type":"CROSSREF","@value":"10.5649/jjphcs1975.19.80"},{"@type":"CIA","@value":"130004103100"}]}