原発性胆汁性肝硬変における自己胆管上皮細胞に対するひ臓由来の細胞傷害性Ｔ細胞活性の測定

DOI Web Site

書誌事項

タイトル別名
  • Cytotoxicity of spleen T lymphocytes against autologous biliary epithelial cells in patients with primary biliary cirrhosis.
公開日
1991
DOI
  • 10.2957/kanzo.32.596
公開者
一般社団法人　日本肝臓学会

この論文をさがす

説明

The mechanism of biliary epithelial cell injury was examined by assessing spleen-derived lymphocyte cytotoxicity to autologous biliary epithelial cells in patients with primary biliary cirrhosis(PBC). Spleen-lymphocytes had cytotoxicity against autologous biliary epithelial cells in all of 3 patients with PBC but in none of 6 patients with non-PBC. The cytotoxicity was found in T cells butnot in non-T cells. CD8 positive T lymphocytes were shown to be responsible for the cytotoxicity by negative depletion and the cytotoxicity was partially suppressed by anti-MHC class I. It was suggested that T cell cytotoxicity functioned through the interaction with MHC class I antigens. The cytotoxicity was dose-dependently suppressed by anti-biliary epithelial cell antibody. Our data support the current hypothesis that the pathogenesis of PBC is due to T cell autoimmunity against biliary epithelium.

収録刊行物

  • 肝臓

    肝臓 32 (6), 596-603, 1991

    一般社団法人　日本肝臓学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ