{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679768276352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2957/kanzo.32.596"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/kanzo1960/32/6/32_6_596/_pdf"}},{"identifier":{"@type":"NAID","@value":"130000878097"}}],"dc:title":[{"@language":"en","@value":"Cytotoxicity of spleen T lymphocytes against autologous biliary epithelial cells in patients with primary biliary cirrhosis."},{"@value":"原発性胆汁性肝硬変における自己胆管上皮細胞に対するひ臓由来の細胞傷害性Ｔ細胞活性の測定"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The mechanism of biliary epithelial cell injury was examined by assessing spleen-derived lymphocyte cytotoxicity to autologous biliary epithelial cells in patients with primary biliary cirrhosis(PBC). Spleen-lymphocytes had cytotoxicity against autologous biliary epithelial cells in all of 3 patients with PBC but in none of 6 patients with non-PBC. The cytotoxicity was found in T cells butnot in non-T cells. CD8 positive T lymphocytes were shown to be responsible for the cytotoxicity by negative depletion and the cytotoxicity was partially suppressed by anti-MHC class I. It was suggested that T cell cytotoxicity functioned through the interaction with MHC class I antigens. The cytotoxicity was dose-dependently suppressed by anti-biliary epithelial cell antibody. Our data support the current hypothesis that the pathogenesis of PBC is due to T cell autoimmunity against biliary epithelium."},{"@value":"原発性胆汁性肝硬変(PBC)患者の脾臓リンパ球の自己胆管上皮細胞に対する細胞傷害活性を測定する系を確立し,胆管上皮細胞の傷害機序を検討した.PBC 3症例の脾臓リンパ球は自己胆管上皮細胞に対して全例が細胞傷害活性を示したが,対照疾患6症例は全例細胞傷害活性を示さなかった.細胞傷害活性はT細胞分画に検出され,non-T細胞分面には検出されなかった.T細胞の細胞傷害活性はnegative depletionよりCD8陽性細胞集団に検出され,抗MHC class I抗体添加により部分的抑制を認め,細胞傷害活性の発現にMHC class I抗原の関与が示唆された.またT細胞傷害活性は抗胆管上皮抗体添加により濃度依存性に抑制された.以上の成績は,PBCの自己免疫機序による胆管上皮細胞傷害に,より直接的な根拠を与えるものと考えられる."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679768276480","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021370368"}],"foaf:name":[{"@language":"en","@value":"NAKATA Shusaku"},{"@language":"ja","@value":"中田 収作"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Internal Medicine, Kochi Medical 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Hepatology"},{"@language":"ja","@value":"一般社団法人　日本肝臓学会"}],"prism:publicationDate":"1991","prism:volume":"32","prism:number":"6","prism:startingPage":"596","prism:endingPage":"603"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/kanzo1960/32/6/32_6_596/_pdf"}],"availableAt":"1991","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=HLA","dc:title":"HLA"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%8E%9F%E7%99%BA%E6%80%A7%E8%83%86%E6%B1%81%E6%80%A7%E8%82%9D%E7%A1%AC%E5%A4%89","dc:title":"原発性胆汁性肝硬変"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%8A%97%E8%83%86%E7%AE%A1%E4%B8%8A%E7%9A%AE%E7%B4%B0%E8%83%9E%E6%8A%97%E4%BD%93","dc:title":"抗胆管上皮細胞抗体"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%83%86%E7%AE%A1%E4%B8%8A%E7%9A%AE%E7%B4%B0%E8%83%9E","dc:title":"胆管上皮細胞"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%B4%B0%E8%83%9E%E5%82%B7%E5%AE%B3%E6%80%A7T%E7%B4%B0%E8%83%9E","dc:title":"細胞傷害性T細胞"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0007766138"},{"@type":"CROSSREF","@value":"10.2957/kanzo.32.596"},{"@type":"CIA","@value":"130000878097"}]}