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AST605IU/<I>l</I>, ALT620IU/<I>l</I>, 総ビリルビン3.4mg/d<I>l</I>. A, B, C, G型肝炎ウイルスマーカーは陰性で, EBウイルス, サイトメガロウイルスは既往感染だった. IgG2009mg/dl, 抗平滑筋抗体160×, HLADR4陽性, 慢性肝炎の組織所見から, 国際診断基準スコアが治療前17点となり, 自己免疫性肝炎 (AIH) (definite) と診断した. プレドニン40mg/日で治療を開始し, 4週間後には肝機能検査が正常化して退院. 18カ月後の現在, プレドニン10mg/日でトランスアミナーゼ, IgG濃度とも正常範囲である. 治療後スコアは19点で, AIH (definite) と診断した. 本例の抗核抗体 (ANA) はHEp-2細胞を用いた間接蛍光抗体法で, 抗セントロメア抗体 (ACA) を示す散在斑紋型 (discretespeckled) のみ陽性だった. 文献上わが国のAIHの約10%がACA/散在斑紋型 ANA 陽性であり, 他の自己免疫疾患の合併が多い以外は臨床像に差異を認めなかった. AIH診断スコアの算定に散在斑紋型も ANA 陽性と見なすことを提案した."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679768554375","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000000387680"}],"foaf:name":[{"@language":"en","@value":"KASHIWAKURA Yuji"},{"@language":"ja","@value":"柏倉 祐司"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679768554497","@type":"Researcher","foaf:name":[{"@language":"en","@value":"HASHIMOTO Naoaki"},{"@language":"ja","@value":"橋本 直明"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679768554379","@type":"Researcher","foaf:name":[{"@language":"en","@value":"MATSUURA Hiroshi"},{"@language":"ja","@value":"松浦 広"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204790865408","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000004234838"}],"foaf:name":[{"@language":"en","@value":"TAKEDA Yasushi"},{"@language":"ja","@value":"竹田 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