{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679777319040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11340/skinresearch1959.26.1060"}},{"identifier":{"@type":"NAID","@value":"130003843341"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1985156292"}}],"dc:title":[{"@value":"化粧品原料の皮膚一次刺激性試験法の比較研究　　培養細胞試験"},{"@language":"en","@value":"Cultured Cell Toxicity Test"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We examined polyols (propylene glycol, 1, 3-butylene glycol and glycerin) using cultured cell toxicity test. The members of this study were 6 researchers in the different 3 cosmetic companies. We performed this test with the same procedure in each laboratory. JTC-17 strain was served for this study. We took the following results; the cell toxicity order of three polyols was 1, 3-butylene glycol > propylene glycol >> glycerin."},{"@value":"グリセリン, プロピレングリコール, 1, 3-ブチレングリコールの細胞障害性をヒト皮膚由来培養細胞株JTC-17を用いて3施設で試験した。その結果, 細胞障害性の順位は1, 3-ブチレングリコール>プロピレングリコール>>グリセリンであった。<BR>細胞障害性の要因の1つに浸透圧が考えられるため, 試験液の浸透圧測定を行ったが, その結果からは浸透圧の大きさが多価アルコールの細胞障害性の主たる原因とは推測し得なかった。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679777319041","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254415718"}],"foaf:name":[{"@language":"en","@value":"KOIZUMI Yoshio"},{"@language":"ja","@value":"小泉 義夫"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratories, Mikimoto pharmaceutical Co., Ltd."},{"@language":"ja","@value":"御木本製薬株式会社研究開発部"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679777319045","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254415717"}],"foaf:name":[{"@language":"en","@value":"TSUTSUMI Masako"},{"@language":"ja","@value":"堤 雅子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Research Laboratory, Pias Co., Ltd."},{"@language":"ja","@value":"ピアス株式会社研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679777319044","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254415719"}],"foaf:name":[{"@language":"en","@value":"HOUNOKI Susumu"},{"@language":"ja","@value":"朴木 進"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Laboratories, Mikimoto pharmaceutical Co., Ltd."},{"@language":"ja","@value":"御木本製薬株式会社研究開発部"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679777319042","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254415716"}],"foaf:name":[{"@language":"en","@value":"NAKANO Eiji"},{"@language":"ja","@value":"中野 栄次"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Research Laboratory, Pias Co., Ltd."},{"@language":"ja","@value":"ピアス株式会社研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679777319040","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254415721"}],"foaf:name":[{"@language":"en","@value":"IGARASHI Atsuko"},{"@language":"ja","@value":"五十嵐 敦子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Laboratories"},{"@language":"ja","@value":"株式会社資生堂研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679777319043","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000254415720"}],"foaf:name":[{"@language":"en","@value":"NAGURA Toshiaki"},{"@language":"ja","@value":"奈蔵 利彰"}],"jpcoar:affiliationName":[{"@language":"en","@value":"SHISEIDO Laboratories"},{"@language":"ja","@value":"株式会社資生堂研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00181390"},{"@type":"EISSN","@value":"1884541X"}],"prism:publicationName":[{"@language":"en","@value":"Skin research"},{"@language":"ja","@value":"皮膚"},{"@language":"en","@value":"Skin Research"},{"@language":"ja","@value":"皮膚"}],"dc:publisher":[{"@language":"en","@value":"Meeting of Osaka Dermatological Association"},{"@language":"ja","@value":"日本皮膚科学会大阪地方会"}],"prism:publicationDate":"1984","prism:volume":"26","prism:number":"5","prism:startingPage":"1060","prism:endingPage":"1064"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/1985156292"}],"availableAt":"1984","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=JTC-17","dc:title":"JTC-17"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%B4%B0%E8%83%9E%E9%9A%9C%E5%AE%B3%E6%80%A7%E8%A9%A6%E9%A8%93","dc:title":"細胞障害性試験"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%9A%E4%BE%A1%E3%82%A2%E3%83%AB%E3%82%B3%E3%83%BC%E3%83%AB","dc:title":"多価アルコール"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%92%E3%83%88%E7%B4%B0%E8%83%9E","dc:title":"ヒト細胞"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0016986274"},{"@type":"CIA","@value":"130003843341"}]}