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Heterotopic bone formation in tumor stromal tissue. Immunohistochemical considerations.
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- KUMASA SHUNSUKE
- Department of Oral Surgery, Asahi University School of Dentistry
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- MORI HIROMITSU
- Department of Oral Surgery, Asahi University School of Dentistry
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- MORI MASAHIKO
- Department of Oral Surgery, Asahi University School of Dentistry
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- SHIBUTANI TOSHIAKI
- Department of Periodontology, Asahi University School of Dentistry
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- IWAYAMA YUKIO
- Department of Periodontology, Asahi University School of Dentistry
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- TSUJIMURA TAKAHIRO
- Department of Pathology, Sumitomo Hospital
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- OHNISHI TOMOKAZU
- Department of Biochemistry, Kagoshima University Dental School
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- ARAKAKI NAOKATSU
- Department of Biochemistry, Kagoshima University Dental School
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- NAKATA MINORU
- Department of Pediatric Dentistry, Faculty of Dentistry, Kyushu University
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- KURISU KOJIRO
- Department of Oral Anatomy, Faculty of Dentistry, Kyushu University
Bibliographic Information
- Other Title
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- IMMUNOHISTOCHEMICAL CONSIDERATIONS
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Description
Ectopic and heterotopic bone formation rarely occur in stromal tissues of various epithelial tumors. In the present study, ectopic bone forming tumors; calcifying epithelioma Malherbe (6), renal cell carcinoma (1), thyroid adenocarcinoma (1) and ovary carcinoma (1) were examined. The process of ectopic bone formation could be classified into 1) bone formation related to epithelial tissue as found in calcifying epithelioma of Malherbe, 2) bone formation from perivascular smooth muscle, and 3) that due to metaplasia occurring in stromal connective tissue of epithelial tumors. Immunohistochemical detection of proteoglycans (PG) was made in bone-forming matrix areas, and these areas were positive for chondrotin 4 and 6 sulfate, and dermatan and heparan sulfate PGs. Immunohistochemically, fibronectin, collagen III and bone sialoprotein as matrix proteins, and carbonic anhydrase as calcification marker were tested and they appeared in these pre-calcifying tissues.
Journal
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- ACTA HISTOCHEMICA ET CYTOCHEMICA
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ACTA HISTOCHEMICA ET CYTOCHEMICA 23 (4), 427-439, 1990
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
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Details 詳細情報について
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- CRID
- 1390282679838076160
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- NII Article ID
- 110003147542
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- NII Book ID
- AA00508022
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- COI
- 1:CAS:528:DyaK3MXhsVSksL8%3D
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- ISSN
- 13475800
- 00445991
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- NDL Digital Collections (NII-ELS)
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed