{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679844353280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2169/internalmedicine1962.21.29"}},{"identifier":{"@type":"PMID","@value":"7069940"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"2479933"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/2479933"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I2479933"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/internalmedicine1962/21/1/21_1_29/_pdf"}},{"identifier":{"@type":"NAID","@value":"130003412624"}},{"identifier":{"@type":"NAID","@value":"40005320547"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"A case of membranous nephropathy associated with thyroid antigens."},{"@language":"ja-Kana","@value":"Case of Membranous Nephropathy Associat"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"A 54-year-old woman who had proteinuria due to stage II membranous nephropathy is reported. She was treated with indomethacin for proteinuria and developed drug-induced hepatitis four months later. Liver dysfunction gradually recovered, but hormonal studies revealed abrupt fall of T<sub>3</sub> and T<sub>4</sub> and concomitant elevation of TSH levels within a month. Pathological findings of thyroid specimen and positive antithyroglobulin and antimicrosomal antibodies were compatible to chronic thyroiditis. In the second renal biogsy, glomerular deposits of thyroglobulin, thyroid microsomal antigens and IgG were demonstrated by immunofluorescence. Therefore, membranous nephropathy in this patient is presumed to be caused by immune complexes mediated by thyroid constituents. We believe that this is a precious case because continuous changes in T<sub>3</sub>, T<sub>4</sub> and TSH were followed in a course of chronic thyroiditis, especially in the stage of progress to hypothyroidism, and the chronic thyroiditis was shown to be involved in the membranous nephropathy."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658403676289","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30184857"},{"@type":"NRID","@value":"1000030184857"},{"@type":"NRID","@value":"9000004103393"},{"@type":"NRID","@value":"9000021349772"},{"@type":"NRID","@value":"9000021394646"},{"@type":"NRID","@value":"9000009540900"},{"@type":"NRID","@value":"9000011167886"},{"@type":"NRID","@value":"9000021284836"},{"@type":"NRID","@value":"9000257800238"},{"@type":"NRID","@value":"9000020340249"},{"@type":"NRID","@value":"9000020375365"},{"@type":"NRID","@value":"9000020375004"},{"@type":"NRID","@value":"9000021844206"},{"@type":"NRID","@value":"9000020040397"},{"@type":"NRID","@value":"9000252796298"},{"@type":"NRID","@value":"9000253110301"},{"@type":"NRID","@value":"9000020014882"},{"@type":"NRID","@value":"9000021295826"}],"foaf:name":[{"@language":"en","@value":"IWAOKA Taisuke"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679844353284","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252796299"}],"foaf:name":[{"@language":"en","@value":"UMEDA Teruhisa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679844353282","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252796300"}],"foaf:name":[{"@language":"en","@value":"NAKAYAMA Mahito"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679844353280","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252796301"}],"foaf:name":[{"@language":"en","@value":"SHIMADA Tatsuya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679844353281","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252796302"}],"foaf:name":[{"@language":"en","@value":"FUJII Yumiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679844353285","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252796303"}],"foaf:name":[{"@language":"en","@value":"MIURA Fumihiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679844353286","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252796304"}],"foaf:name":[{"@language":"en","@value":"SATO Tatsuo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the Third Department of Internal Medicine, Kumamoto University School of Medicine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00215120"},{"@type":"EISSN","@value":"1881123X"},{"@type":"NDL_BIB_ID","@value":"000000126718"},{"@type":"ISSN","@value":"00215120"},{"@type":"LISSN","@value":"00215120"},{"@type":"NCID","@value":"AA00691133"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Medicine"},{"@language":"en","@value":"Jpn J Med"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Internal Medicine"},{"@language":"ja","@value":"社団法人 日本内科学会"}],"prism:publicationDate":"1982","prism:volume":"21","prism:number":"1","prism:startingPage":"29","prism:endingPage":"34"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/2479933"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I2479933"},{"@id":"http://www.jstage.jst.go.jp/article/internalmedicine1962/21/1/21_1_29/_pdf"}],"availableAt":"1982","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Immune%20complex","dc:title":"Immune complex"},{"@id":"https://cir.nii.ac.jp/all?q=Membranous%20nephropathy","dc:title":"Membranous nephropathy"},{"@id":"https://cir.nii.ac.jp/all?q=Chronic%20thyroiditis","dc:title":"Chronic thyroiditis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/2050025942159547520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A case of membranous nephropathy secondary to asymptomatic Graves’ 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