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Patients with CAH received a four-week regimen of prednisolone with daily dosage tapering from 40 to 10 mg (total 700 mg). Within one year after the withdrawal of prednisolone, 19 (70%) lost HBeAg and 11 of them (41% of the total) developed anti-HBe, at rates significantly higher than 3 (12%) and 1 (4%) who spontaneously showed respective serological changes among 26 matched controls during one year (p < 0.001). Within two years after the withdrawal, 21 (78%) lost HBeAg and 19 (70%) developed anti-HBe, in contrast to 6 (23%) and 2 (8%) of controls who showed respective changes during that period (p < 0.001). Seroconversion to anti-HBe was invariably accompanied by clinical and biochemical improvements along with loss of DNA polymerase from circulation. Elevation in transaminase levels, reflecting the rebound of steroid withdrawal, always heralded and appeared to be required for the seroconversion, but serious aggravation of hepatitis was not encountered in any of the 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Mineo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Kojima Naika Clinic"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679845565827","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253111281"}],"foaf:name":[{"@language":"en","@value":"SUZUKI Hiroshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"the First Department of Internal Medicine, Yamanashi Medical College"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679845565830","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000253111282"}],"foaf:name":[{"@language":"en","@value":"MAYUMI Makoto"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Immunology Division, Jichi Medical School"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00215120"},{"@type":"EISSN","@value":"1881123X"}],"prism:publicationName":[{"@language":"en","@value":"Japanese Journal of Medicine"},{"@language":"en","@value":"Jpn J Med"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Internal Medicine"},{"@language":"ja","@value":"社団法人 日本内科学会"}],"prism:publicationDate":"1987","prism:volume":"26","prism:number":"2","prism:startingPage":"217","prism:endingPage":"222"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://www.jstage.jst.go.jp/article/internalmedicine1962/26/2/26_2_217/_pdf"}],"availableAt":"1987","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20virus","dc:title":"Hepatitis B virus"},{"@id":"https://cir.nii.ac.jp/all?q=Chronic%20hepatitis%20B","dc:title":"Chronic hepatitis B"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B%20e%20antigen","dc:title":"Hepatitis B e antigen"},{"@id":"https://cir.nii.ac.jp/all?q=Seroconversion","dc:title":"Seroconversion"},{"@id":"https://cir.nii.ac.jp/all?q=Corticosteroid","dc:title":"Corticosteroid"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/2050870367073795072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prevention of hepatitis B virus reactivation in immunosuppressive therapy or chemotherapy"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0017196974"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine1962.26.217"},{"@type":"PUBMED","@value":"3626161"},{"@type":"CIA","@value":"130003514025"},{"@type":"OPENAIRE","@value":"doi_dedup___::7885d291943d10a372399be2e23495f3"},{"@type":"CROSSREF","@value":"10.1007/s10157-011-0464-7_references_DOI_BOttmizuYbFjHC18DnFDJxWvNFH"}]}