{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679848816640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2169/internalmedicine.52.9458"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BC3sjmsVygug%3D%3D"}},{"identifier":{"@type":"PMID","@value":"23812192"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/internalmedicine/52/13/52_52.9458/_pdf"}},{"identifier":{"@type":"NAID","@value":"130003365695"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014231669"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Liver Dysfunction in Patients with Systemic Lupus Erythematosus"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<b>Objective</b> We aimed to define the clinical features of liver dysfunction in patients with systemic lupus erythematosus (SLE).<br> <b>Methods</b> The frequency and causes of liver dysfunction were examined in 206 patients with SLE.<br> <b>Results</b> Liver dysfunction was evident in 123 (59.7%) of the 206 patients. Liver dysfunction in patients with SLE can be drug-induced (30.9%) or caused by SLE itself (28.5%), fatty liver (17.9%), autoimmune hepatitis (AIH) (4.9%), primary biliary cirrhosis (2.4%), cholangitis (1.6%), alcohol (1.6%) or viral hepatitis (0.8%), and it tends to be mild except when caused by AIH. Values for aminotransferase were significantly increased when AIH was the cause, whereas alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GTP) were significantly increased when AIH or drugs were the cause. The liver was already dysfunctional at the time of SLE onset in 56 (45.5%) of 123 patients with liver dysfunction. Neurological involvement was more common among patients with than without liver dysfunction, whereas SLE activity and prognosis did not significantly differ between the two groups.<br> <b>Conclusion</b> Liver dysfunction in the presence of SLE can be caused by many factors, but when extant at the time of SLE onset, either SLE itself or drugs can be the cause. Autoimmune hepatitis should be considered when liver dysfunction is relatively severe.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679848816641","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056551"}],"foaf:name":[{"@language":"en","@value":"Takahashi Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816649","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056555"}],"foaf:name":[{"@language":"en","@value":"Abe Kazumichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816644","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056556"}],"foaf:name":[{"@language":"en","@value":"Saito Rie"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816648","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056557"}],"foaf:name":[{"@language":"en","@value":"Iwadate Haruyo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816647","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056558"}],"foaf:name":[{"@language":"en","@value":"Okai Ken"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816645","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056552"}],"foaf:name":[{"@language":"en","@value":"Kobayashi Hiroko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816640","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056561"}],"foaf:name":[{"@language":"en","@value":"Kanno Yukiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816651","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056553"}],"foaf:name":[{"@language":"en","@value":"Watanabe Hiroshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816650","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056554"}],"foaf:name":[{"@language":"en","@value":"Ohira Hiromasa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816643","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056559"}],"foaf:name":[{"@language":"en","@value":"Katsushima Fumiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816642","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056562"}],"foaf:name":[{"@language":"en","@value":"Saito Hironobu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679848816646","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000240056560"}],"foaf:name":[{"@language":"en","@value":"Monoe Kyoko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09182918"},{"@type":"EISSN","@value":"13497235"}],"prism:publicationName":[{"@language":"en","@value":"Internal Medicine"},{"@language":"en","@value":"Intern. Med."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Internal Medicine"},{"@language":"ja","@value":"一般社団法人 日本内科学会"}],"prism:publicationDate":"2013","prism:volume":"52","prism:number":"13","prism:startingPage":"1461","prism:endingPage":"1465"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/internalmedicine/52/13/52_52.9458/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2014231669"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=SLE","dc:title":"SLE"},{"@id":"https://cir.nii.ac.jp/all?q=liver%20dysfunction","dc:title":"liver dysfunction"},{"@id":"https://cir.nii.ac.jp/all?q=autoimmune%20hepatitis","dc:title":"autoimmune hepatitis"},{"@id":"https://cir.nii.ac.jp/all?q=anti-ribosomal%20P%20antibody","dc:title":"anti-ribosomal P antibody"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282813895513856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1050865817813687040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical features of liver dysfunction in collagen diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186632830336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Systemic lupus erythematosus complicated with liver cirrhosis in a patient with Papillon-Lefèvre syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093841532672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The 1982 revised criteria for the classification of systemic lupus erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570348855680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessment of 287 Japanese cases of drug induced liver injury by the diagnostic scale of the International Consensus Meeting"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571296242304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical and biological aspects of anti-P-ribosomal protein autoantibodies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519211647744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vasculitis in systemic lupus erythematosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521071007744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence and Risk Factors for Liver Biochemical Abnormalities in Canadian Patients with Systemic Lupus Erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371079129856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The spectrum of liver disease in systemic lupus erythematosus. 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