{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679849446144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2169/internalmedicine.51.6021"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BC38vps12rtQ%3D%3D"}},{"identifier":{"@type":"PMID","@value":"22449662"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/internalmedicine/51/6/51_6_559/_pdf"}},{"identifier":{"@type":"NAID","@value":"130002061912"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013185238"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"High Serum Thioredoxin Levels Are Reduced after Tonsillectomy in Patients with IgA Nephropathy"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<b>Objective</b> The role of oxidative stress in IgA nephropathy (IgAN), the most common type of primary glomerulonephritis, is unknown. We evaluated the clinical significance of serum levels of oxidative stress markers, thioredoxin (TRX) and manganese superoxide dismutase (MnSOD), in patients with IgAN.<br> <b>Methods</b> Forty-eight patients with histologically confirmed IgAN and 14 healthy subjects were enrolled in this study. Serum samples from 14 IgAN patients were obtained after tonsillectomy, a procedure hypothesized to be an effective treatment for IgAN.<br> <b>Results</b> Serum TRX levels were significantly higher in patients with IgAN than in healthy subjects (mean [ng/mL]; 49.5 vs.14.4, p<0.001). Serum TRX levels are positively correlated with blood urea nitrogen, serum uric acid and proteinuria, and negatively with estimated glomerular filtration rate (eGFR). In addition, serum TRX levels gradually increased as the severity of renal histology increased. High levels of serum TRX were significantly decreased after tonsillectomy in patients with IgAN (mean [ng/mL]; 55.5 to 41.1, p=0.02). In contrast, serum MnSOD levels did not differ between IgAN patients and healthy subjects, and these levels did not change after tonsillectomy in IgAN patients.<br> <b>Conclusion</b> Serum TRX is associated with IgAN, and tonsillectomy may decrease oxidative stress in IgAN patients, leading to clinical improvement.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679849446145","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066518"}],"foaf:name":[{"@language":"en","@value":"Nosaki Tsuyoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658834998784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20347058"},{"@type":"NRID","@value":"1000020347058"},{"@type":"NRID","@value":"9000300215497"},{"@type":"NRID","@value":"9000257940945"},{"@type":"NRID","@value":"9000305640949"},{"@type":"NRID","@value":"9000272997440"},{"@type":"NRID","@value":"9000018964390"},{"@type":"NRID","@value":"9000391969493"},{"@type":"NRID","@value":"9000242077433"},{"@type":"NRID","@value":"9000018583448"},{"@type":"NRID","@value":"9000391978535"},{"@type":"NRID","@value":"9000022066528"},{"@type":"NRID","@value":"9000411808368"},{"@type":"NRID","@value":"9000360588670"},{"@type":"NRID","@value":"9000256596924"}],"foaf:name":[{"@language":"en","@value":"Uto Hirofumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658591133440","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10500473"},{"@type":"NRID","@value":"1000010500473"},{"@type":"NRID","@value":"9000398803284"},{"@type":"NRID","@value":"9000249249918"},{"@type":"NRID","@value":"9000321413826"},{"@type":"NRID","@value":"9000317155072"},{"@type":"NRID","@value":"9000005289917"},{"@type":"NRID","@value":"9000326652659"},{"@type":"NRID","@value":"9000402124201"},{"@type":"NRID","@value":"9000249256283"},{"@type":"NRID","@value":"9000022066529"}],"foaf:name":[{"@language":"en","@value":"Takami Yoichiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446152","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066531"}],"foaf:name":[{"@language":"en","@value":"Oku Manei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446151","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066533"}],"foaf:name":[{"@language":"en","@value":"Fukumoto Mayumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446147","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066535"}],"foaf:name":[{"@language":"en","@value":"Mera Kumiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446146","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066537"}],"foaf:name":[{"@language":"en","@value":"Nishida Chika"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446156","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066539"}],"foaf:name":[{"@language":"en","@value":"Tokunaga Koki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446149","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066540"}],"foaf:name":[{"@language":"en","@value":"Sogabe Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658395401088","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50274816"},{"@type":"NRID","@value":"1000050274816"},{"@type":"NRID","@value":"9000020926510"},{"@type":"NRID","@value":"9000240108368"},{"@type":"NRID","@value":"9000001883673"},{"@type":"NRID","@value":"9000002887470"},{"@type":"NRID","@value":"9000243890274"},{"@type":"NRID","@value":"9000001503859"},{"@type":"NRID","@value":"9000399375282"},{"@type":"NRID","@value":"9000022066520"},{"@type":"NRID","@value":"9000411808378"},{"@type":"NRID","@value":"9000022105900"},{"@type":"NRID","@value":"9000347091075"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0184760"}],"foaf:name":[{"@language":"en","@value":"Oketani Makoto"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, 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Akio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679849446155","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022066524"}],"foaf:name":[{"@language":"en","@value":"Kurono Yuichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otolaryngology Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751152480256","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60145480"},{"@type":"NRID","@value":"1000060145480"},{"@type":"NRID","@value":"9000020926513"},{"@type":"NRID","@value":"9000300215495"},{"@type":"NRID","@value":"9000242086277"},{"@type":"NRID","@value":"9000021871693"},{"@type":"NRID","@value":"9000005808337"},{"@type":"NRID","@value":"9000020411190"},{"@type":"NRID","@value":"9000242082356"},{"@type":"NRID","@value":"9000021468772"},{"@type":"NRID","@value":"9000021482434"},{"@type":"NRID","@value":"9000242077392"},{"@type":"NRID","@value":"9000256568415"},{"@type":"NRID","@value":"9000021545239"},{"@type":"NRID","@value":"9000347038255"},{"@type":"NRID","@value":"9000347120618"},{"@type":"NRID","@value":"9000243890185"},{"@type":"NRID","@value":"9000266899147"},{"@type":"NRID","@value":"9000256349426"},{"@type":"NRID","@value":"9000021488785"},{"@type":"NRID","@value":"9000020594180"},{"@type":"NRID","@value":"9000020593233"},{"@type":"NRID","@value":"9000258037291"},{"@type":"NRID","@value":"9000309562708"},{"@type":"NRID","@value":"9000020412127"},{"@type":"NRID","@value":"9000020535808"},{"@type":"NRID","@value":"9000391969495"},{"@type":"NRID","@value":"9000258205419"},{"@type":"NRID","@value":"9000258017904"},{"@type":"NRID","@value":"9000397435786"},{"@type":"NRID","@value":"9000253567369"},{"@type":"NRID","@value":"9000020562596"},{"@type":"NRID","@value":"9000283328232"},{"@type":"NRID","@value":"9000241881771"},{"@type":"NRID","@value":"9000391969532"},{"@type":"NRID","@value":"9000256350290"},{"@type":"NRID","@value":"9000375849832"},{"@type":"NRID","@value":"9000391978536"},{"@type":"NRID","@value":"9000022066526"},{"@type":"NRID","@value":"9000411808382"},{"@type":"NRID","@value":"9000256377300"},{"@type":"NRID","@value":"9000258559003"},{"@type":"NRID","@value":"9000415049034"},{"@type":"NRID","@value":"9000020563691"},{"@type":"NRID","@value":"9000391973139"},{"@type":"NRID","@value":"9000360588668"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0048913"}],"foaf:name":[{"@language":"en","@value":"Tsubouchi Hirohito"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09182918"},{"@type":"EISSN","@value":"13497235"}],"prism:publicationName":[{"@language":"en","@value":"Internal Medicine"},{"@language":"en","@value":"Intern. Med."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Internal Medicine"},{"@language":"ja","@value":"一般社団法人 日本内科学会"}],"prism:publicationDate":"2012","prism:volume":"51","prism:number":"6","prism:startingPage":"559","prism:endingPage":"565"},"reviewed":"false","url":[{"@id":"https://www.jstage.jst.go.jp/article/internalmedicine/51/6/51_6_559/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2013185238"}],"availableAt":"2012","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=tonsillectomy","dc:title":"tonsillectomy"},{"@id":"https://cir.nii.ac.jp/all?q=thioredoxin","dc:title":"thioredoxin"},{"@id":"https://cir.nii.ac.jp/all?q=IgA%20nephropathy","dc:title":"IgA nephropathy"},{"@id":"https://cir.nii.ac.jp/all?q=biomarker","dc:title":"biomarker"},{"@id":"https://cir.nii.ac.jp/all?q=oxidative%20stress","dc:title":"oxidative stress"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257074307712","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21790673"},{"@type":"JGN","@value":"JP21790673"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790673/"}],"notation":[{"@language":"ja","@value":"HGFによる肝細胞分化誘導メカニズムの解明"},{"@language":"en","@value":"Elucidation of mechanisms for hepatic differentiation by HGF"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257122216064","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23249043"},{"@type":"JGN","@value":"JP23249043"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23249043/"}],"notation":[{"@language":"ja","@value":"プロテオミクスを用いた難治性消化器疾患の病態解明と新規診断・治療法の確立"},{"@language":"en","@value":"Using proteomics to elucidate pathogenesis and establish new diagnostic or treatment evaluation methods in refractory gastrointestinal diseases"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292618565737856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early prediction of IgA nephropathy progression: Proteinuria and AOPP are strong prognostic markers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620429971584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621170417792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"REDOX REGULATION OF CELLULAR ACTIVATION"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621216519168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential Effects of Circulating IgA Isolated from Patients with IgA Nephropathy on Superoxide and Fibronectin Production of Mesangial 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patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044872185088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A meta-analysis of the clinical remission rate and long-term efficacy of tonsillectomy in patients with IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994142853248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Moderately Proteinuric IgA Nephropathy: Prognostic Prediction of Individual Clinical Courses and Steroid Therapy in Progressive Cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468579278080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468648786688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced intrarenal oxidative stress and angiotensinogen in IgA nephropathy patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943693471744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945083804032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thioredoxin"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945089436800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vitamin E Ameliorates Renal Injury in an Experimental Model of Immunoglobulin A Nephropathy1"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945856050048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893358717696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidative Stress in IgA Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369905472512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Corticosteroid Effectiveness in IgA Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843290297472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318495364992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Steroid Therapy during the Early Stage of Progressive IgA Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320246879744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>Infection Induces Oxidative Stress and Programmed Cell Death in Human Gastric Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794420627456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IgA Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268664745344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Corticosteroids in IgA nephropathy: a randomised controlled trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268936448768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074193578496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equations for estimated GFR from serum creatinine in Japan. American journal of kidney diseases: the official journal of the"},{"@value":"Revised equations for estimating glomerular filtration rate (GFR) from serum creatinine in Japan"},{"@value":"Hishida A; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimating GFR. Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimated GFR"},{"@value":"Japanese equation for estimated GFR"},{"@value":"Revised equation for estimating glomerular filtration rate (GFR) from serum creatinin in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842048569216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical guidelines for immunoglobulin A (IgA) nephropathy in Japan, second version"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1000003426"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.51.6021"},{"@type":"PUBMED","@value":"22449662"},{"@type":"CIA","@value":"130002061912"},{"@type":"KAKEN","@value":"PRODUCT-13110868"},{"@type":"KAKEN","@value":"PRODUCT-13830462"},{"@type":"KAKEN","@value":"PRODUCT-13830499"}]}