{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679878075136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2131/jts.35.265"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10652100"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/10652100"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I10652100"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jts/35/2/35_2_265/_pdf"}},{"identifier":{"@type":"PMID","@value":"20371980"}},{"identifier":{"@type":"NAID","@value":"10026193564"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2010278648"}}],"dc:title":[{"@language":"en","@value":"Serum level of expressed in renal carcinoma (ERC)/ mesothelin  in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Expressed in renal carcinoma (ERC)/mesothelin is a good biomarker for human mesothelioma and has been investigated for its mechanistic rationale during the mesothelioma development. Studies are thus ongoing in our laboratories to assess expression of ERC/mesothelin in sera and normal/proliferative/neoplastic mesothelial tissues of animals untreated or given potentially mesothelioma-inducible xenobiotics, by an enzyme-linked immunosorbent assay (ELISA) for N- and C-(terminal fragments of) ERC/mesothelin and immunohistochemistry for C-ERC/mesothelin. In the present paper, we intend to communicate our preliminary data, because this is the first report to show how and from what stage the ERC/mesothelin expression changes during the chemical induction of mesothelial proliferative/neoplatic lesions. Serum N-ERC/mesothelin levels were 51.4 ± 5.6 ng/ml in control male Fischer 344 rats, increased to 83.6 ± 11.2 ng/ml in rats given a single intrascrotal administration of 1 mg/kg body weight of multi-wall carbon nanotube (MWCNT) and bearing mesothelial hyperplasia 52 weeks thereafter, and further elevated to 180 ± 77 ng/ml in rats similarly treated and becoming moribund 40 weeks thereafter, or killed as scheduled at the end of week 52, bearing mesothelioma. While C-ERC/mesothelin was expressed in normal and hyperplastic mesothelia, the protein was detected only in epithelioid mesothelioma cells at the most superficial layer. It is thus suggested that ERC/mesothelin can be used as a biomarker of mesothelial proliferative lesions also in animals, and that the increase of levels may start from the early stage and be enhanced by the progression of the mesothelioma development."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679878075146","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017276664"}],"foaf:name":[{"@language":"en","@value":"Hagiwara Yoshiaki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology and Oncology, Juntendo University School of Medicine"},{"@language":"en","@value":"Immuno-Biological Laboratory Co., Ltd."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878075136","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006885559"}],"foaf:name":[{"@language":"en","@value":"Sakamoto Yoshimitsu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Environmental Health 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Akio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878075140","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Satoh Kanako"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03881350"},{"@type":"LISSN","@value":"03881350"},{"@type":"EISSN","@value":"18803989"},{"@type":"NDL_BIB_ID","@value":"000000032748"},{"@type":"ISSN","@value":"03881350"},{"@type":"NCID","@value":"AN00002808"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of Toxicological Sciences"},{"@language":"ja","@value":"Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ"},{"@language":"en","@value":"J. 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