{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679878328448.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2131/jts.16.supplementi_95"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jts1976/16/SupplementI/16_SupplementI_95/_pdf"}},{"identifier":{"@type":"NAID","@value":"110001804984"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1993232555"}}],"dc:title":[{"@language":"en","@value":"5-1) 8-HYDROXYGUANINE, A DNA ADDUCT FORMED BY OXYGEN RADICALS : ITS IMPLICATION ON OXYGEN RADICAL-INVOLVED MUTAGENESIS/CARCINOGENESIS"},{"@value":"8-Hydroxyguanine, a DNA adduct formed by oxygen radicals: its implication on oxygen radical-involved mutagenesis/carcinogenesis"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Oxygen radicals have been suggested to be involved in mutation/carcinogenesis. The C-8 position of guanine residues in DNA is hydroxylated to produce 8-hydroxyguanine(8-OH-Gua) in DNA in vitro by various oxygen radical producing agents. The formation of 8-OH-Gua was also observed in cellular DNA in vivo by radiation or oxygen radical forming carcinogens. The 8-OH-Gua residue in DNA is often misread in the position of 8-OH-Gua residue itself but also at neighboring residues next to 8-OH-Gua. When second guanine in codon 12 was specifically replaced with 8-OH-Gua and transferred to NIH3T3, the recipient cells were transformed to malignant cell type. E. coli was found to contain an endonuclease which specifically recognizes 8-OH-Gua residue and cleave DNA strand before and after the modified base. The data obtained imply that 8-OH-Gua formed in DNA in vivo is recognized as an abnormal modified base which, if not repaired, play a role in the mediation of oxygen radical-involved mutation/carcinogenesis."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679878328451","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033527"}],"foaf:name":[{"@language":"en","@value":"Kasai H."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328454","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033531"}],"foaf:name":[{"@language":"en","@value":"Chung M. H."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328453","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033537"}],"foaf:name":[{"@language":"en","@value":"Jones D. S."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328455","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033543"}],"foaf:name":[{"@language":"en","@value":"Inoue H."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328452","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033550"}],"foaf:name":[{"@language":"en","@value":"Ishikawa H."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328450","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033555"}],"foaf:name":[{"@language":"en","@value":"Kamiya H."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328448","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033560"}],"foaf:name":[{"@language":"en","@value":"Ohtsuka E."}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679878328449","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021033566"}],"foaf:name":[{"@language":"en","@value":"Nishimura S."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03881350"},{"@type":"LISSN","@value":"03881350"},{"@type":"EISSN","@value":"18803989"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/03881350"},{"@type":"NCID","@value":"AN00002808"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of Toxicological Sciences"},{"@language":"ja","@value":"Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ"},{"@language":"en","@value":"J. Toxicol. Sci."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Toxicology"},{"@language":"ja","@value":"一般社団法人　日本毒性学会"}],"prism:publicationDate":"1991","prism:volume":"16","prism:number":"SupplementI","prism:startingPage":"95","prism:endingPage":"105"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/jts1976/16/SupplementI/16_SupplementI_95/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/1993232555"}],"availableAt":"1991","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=mutagenesis/carcinogenesis","dc:title":"mutagenesis/carcinogenesis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567184176163712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118742662272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanism of reactive oxygen species generation and oxidative DNA damage induced by acrylohydroxamic acid, a putative metabolite of acrylamide"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341811527936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Myricetin causes site-specific DNA damage via reactive oxygen species generation by redox interactions with copper ions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865815485651840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oxidative DNA damage: Induction by fructose, in vitro, and its enhancement by hydrogen peroxide"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204455020544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Effects of 1-Nitropyrene on Oxidative DNA Damage and Expression of DNA Repair Enzymes"},{"@language":"ja-Kana","@value":"Effects of 1 Nitropyrene on Oxidative DNA Damage and Expression of DNA Repair Enzymes"},{"@value":"The Effects of 1‐Nitropyrene on Oxidative DNA Damage and Expression of DNA Repair Enzymes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204790799616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Ｎｏｎａｌｃｏｈｏｌｉｃ　Ｓｔｅａｔｏｈｅｐａｔｉｔｉｓ（ＮＡＳＨ）への実験医学的アプローチ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205256387328","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanism of Oxidative DNA Damage Induced by Environmental Carcinogens and Antioxidants"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206440507776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"医学と医療の最前線　　脂肪肝から肝がんへ…動物モデルから見たＮＡＳＨの新展開"},{"@language":"ja-Kana","@value":"イガク ト イリョウ ノ サイゼンセン シボウ カン カラ カン ガン エ ドウブツ モデル カラ ミタ NASH ノ シン テンカイ"},{"@language":"en","@value":"[From fatty liver to liver cancer--new development in non-alcoholic steatohepatitis (NASH) using animal models]."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679391993600","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Promotion Effect of a Choline-deficient L-amino Acid-defined (CDAA) Diet on Hepatocellular Foci Formation Initiated by Diethylnitrosamine in Fischer 344 Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/2051996266990690304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Copper-mediated DNA damage caused by purpurin, a natural anthraquinone"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0036253929"},{"@type":"CROSSREF","@value":"10.2131/jts.16.supplementi_95"},{"@type":"CIA","@value":"110001804984"},{"@type":"CROSSREF","@value":"10.1293/tox.14.105_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"},{"@type":"CROSSREF","@value":"10.1186/s41021-022-00245-2_references_DOI_O4b9GlPVbYoYXxiTMgGcOGUTkXT"},{"@type":"CROSSREF","@value":"10.1539/joh.47.261_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"},{"@type":"CROSSREF","@value":"10.1080/10715762.2018.1562179_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"},{"@type":"CROSSREF","@value":"10.3123/jemsge.30.1_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"},{"@type":"CROSSREF","@value":"10.1016/j.mrgentox.2021.503420_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"},{"@type":"CROSSREF","@value":"10.1016/j.mrgentox.2023.503694_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"},{"@type":"CROSSREF","@value":"10.1016/j.mrgentox.2023.503719_references_DOI_M2mNqR8l1eajYQb3p2veosnU3Ec"}]}