{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679881479040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2131/jts.38.503"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BC3sXhtVKhsL3N"}},{"identifier":{"@type":"PMID","@value":"23719928"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"024784154"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/024784154"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I024784154"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jts/38/3/38_503/_pdf"}},{"identifier":{"@type":"NAID","@value":"10031158916"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014081413"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Genotoxicity and reactive oxygen species production induced by magnetite nanoparticles in mammalian cells"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"We examined the genotoxicity of magnetite nanoparticles (primary particle size: 10 nm) on human A549 and Chinese hamster ovary (CHO) AA8 cells. Six hours’ treatment with the particles dose-dependently increased the frequency of micronuclei (MN) in the A549 and CHO AA8 cells up to 5.2% and 5.0% at a dose of 200 µg/ml (34 µg/cm<sup>2</sup>), respectively. In A549 cells, treatment with the nano­particles (2 µg/ml) for 1 hr induced H2AX phosphorylation, which is suggestive of DNA double strand breaks (DSB). Treating CHO AA8 cells with 2 µg/ml (0.34 µg/cm<sup>2</sup>) magnetite for 1 hour resulted in a five times higher frequency of sister chromatid exchange (SCE) than the control level. We detected reactive oxygen species (ROS) in CHO cells treated with the particles. These findings indicate that magnetite nano­particles induce ROS in mammalian cells, leading to the direct or indirect induction of DSB, followed by clastogenic events including MN and SCE."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326223739008","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70332963"},{"@type":"NRID","@value":"1000070332963"},{"@type":"NRID","@value":"9000014611520"},{"@type":"NRID","@value":"9000363399634"},{"@type":"NRID","@value":"9000363399595"},{"@type":"NRID","@value":"9000255723718"},{"@type":"NRID","@value":"9000363399614"},{"@type":"NRID","@value":"9000257967103"},{"@type":"NRID","@value":"9000018362446"},{"@type":"NRID","@value":"9000363399618"},{"@type":"NRID","@value":"9000363399645"},{"@type":"NRID","@value":"9000363399460"},{"@type":"NRID","@value":"9000363399524"},{"@type":"NRID","@value":"9000006939400"},{"@type":"NRID","@value":"9000363399476"},{"@type":"NRID","@value":"9000006939411"},{"@type":"NRID","@value":"9000360556413"},{"@type":"NRID","@value":"9000363399441"},{"@type":"NRID","@value":"9000363399510"},{"@type":"NRID","@value":"9000242882805"},{"@type":"NRID","@value":"9000363399619"},{"@type":"NRID","@value":"9000363399474"},{"@type":"NRID","@value":"9000363399571"},{"@type":"NRID","@value":"9000258742855"},{"@type":"NRID","@value":"9000363399543"},{"@type":"NRID","@value":"9000363399588"},{"@type":"NRID","@value":"9000021810533"},{"@type":"NRID","@value":"9000409026211"},{"@type":"NRID","@value":"9000363399545"},{"@type":"NRID","@value":"9000257946522"},{"@type":"NRID","@value":"9000018723797"},{"@type":"NRID","@value":"9000405671257"},{"@type":"NRID","@value":"9000363399613"},{"@type":"NRID","@value":"9000363399620"},{"@type":"NRID","@value":"9000409026227"},{"@type":"NRID","@value":"9000363399547"},{"@type":"NRID","@value":"9000363399508"},{"@type":"NRID","@value":"9000363399598"},{"@type":"NRID","@value":"9000255723722"},{"@type":"NRID","@value":"9000363399551"},{"@type":"NRID","@value":"9000363399549"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0057385"}],"foaf:name":[{"@language":"en","@value":"Kawanishi 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Yukari"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Cancer Development System, National Cancer Center Research Institute"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276187524864","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60584878"},{"@type":"NRID","@value":"1000060584878"},{"@type":"NRID","@value":"9000018431643"},{"@type":"NRID","@value":"9000240184373"},{"@type":"NRID","@value":"9000018565776"},{"@type":"NRID","@value":"9000258742859"},{"@type":"NRID","@value":"9000347094109"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/60584878"}],"foaf:name":[{"@language":"en","@value":"Ishino Kousuke"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Cancer Development System, National Cancer Center Research 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Takashi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Graduate School of Science and Radiation Research Center, Osaka Prefecture University"},{"@language":"en","@value":"Department of Life Science, Dongguk University Seoul"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03881350"},{"@type":"LISSN","@value":"03881350"},{"@type":"EISSN","@value":"18803989"},{"@type":"NDL_BIB_ID","@value":"000000032748"},{"@type":"ISSN","@value":"03881350"},{"@type":"NCID","@value":"AN00002808"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of Toxicological Sciences"},{"@language":"ja","@value":"Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ"},{"@language":"en","@value":"J. Toxicol. Sci."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Society of Toxicology"},{"@language":"ja","@value":"一般社団法人　日本毒性学会"}],"prism:publicationDate":"2013","prism:volume":"38","prism:number":"3","prism:startingPage":"503","prism:endingPage":"511"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/024784154"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I024784154"},{"@id":"https://www.jstage.jst.go.jp/article/jts/38/3/38_503/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2014081413"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Magnetite%20nanoparticles","dc:title":"Magnetite nanoparticles"},{"@id":"https://cir.nii.ac.jp/all?q=Genotoxicity","dc:title":"Genotoxicity"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20damage","dc:title":"DNA damage"},{"@id":"https://cir.nii.ac.jp/all?q=Reactive%20oxygen%20species","dc:title":"Reactive oxygen 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