血小板及び血しょうアフェレーシス実施時の血液アナフィラトキシン値の変動
書誌事項
- タイトル別名
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- Changes in Anaphylatoxin Levels of Blood Donors During Plateletapheresis and Plasmapheresis Procedures.
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説明
The activation of anaphylatoxins during hemapheresis procedures including 3 plateletapheresis and 2 plasmapheresis procedures was studied. The membrane filtration plasmapheresis procedures using APC-4000 (Asahi) and Autopheresis C (Baxter) generated very high levels of C3a of 1254±332ng/ml and of 1435±310ng/ml, respectively. While, the plateletapheresis procedures including the blood centrifugation steps with MCS (Haemonetics), CS-3000 (Baxter), and Spectra (Cobe) elicited much less C3a generation of mean values of 287ng/ml, 471ng/ml and 418ng/ml, respectively. The obtained plasma products from 5 hemapheresis procedures contained high levels of C3a of 303 to 1116ng/ml. All the hemapheresis procedures did not induce C5a but most platelet concentrates and plasma products contained increased C5a levels of 22 to 29 ng/ml. On the other hand, C4a also increased with two membrane-plasmapheresis procedures for 114 to 606ng/ml even if there is no evidence of classical pathway activation. Finally C3a is a most reliable indicator for complement activation during hemapheresis procedures.
収録刊行物
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- 日本輸血学会雑誌
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日本輸血学会雑誌 41 (3), 224-229, 1995
一般社団法人 日本輸血・細胞治療学会
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詳細情報 詳細情報について
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- CRID
- 1390282679885263872
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- NII論文ID
- 130003706901
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- ISSN
- 18838383
- 05461448
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可