This study aimed to survey the current situation of polypharmacy and the characteristics of patients under diabetic treatment who prefer a once-weekly oral hypoglycemic agent (OHA). Among 520 outpatients who were receiving diabetic treatment in our hospital (age, 67±11 years; HbA1c, 7.0±0.8 %; Duration of diabetes, 14±9 years), 413 (79 %) were treated with multiple agents. A multivariate logistic regression analysis revealed that age (OR 1.03 [1.00-1.05]), diabetes duration (OR 1.05 [1.01-1.08]), HbA1c (OR 1.63 [1.15-2.31]), hypertension (OR 10.25 [5.15-20.41]), and the number of clinical departments (OR 1.93 [1.47-2.54]) were independent predictors of polypharmacy. A questionnaire survey revealed that 73 % of the patients preferred a once-weekly OHA, and that the patients who preferred a once-weekly OHA were significantly younger, were more often male, and used more types of medication for diabetes than those who did not prefer a once-weekly OHA. These findings suggest that polypharmacy is prevalent in diabetic patients. In addition, the percentage of patients who preferred once-weekly OHA was high. Furthermore, this patient group was younger, showed a male predominance, and used several types of diabetes medications.
"},{"@language":"ja","@value":"薬物療法中の糖尿病患者を対象に，ポリファーマシーの実態および週1回の経口血糖降下薬を希望する患者の背景因子を調査した．520例中（年齢67±11歳，HbA1c7.0±0.8 %，糖尿病罹病期間14±9年）79 %がポリファーマシーに該当し，年齢（OR 1.03），糖尿病罹病期間（OR 1.05），HbA1c（OR 1.63），高血圧合併（OR 10.25），通院診療科数（OR 1.93）がポリファーマシーの独立した関連因子として抽出された．経口血糖降下薬のうち，週1回製剤への変更を22 %が「大いに希望する」，51 %が「希望する」，28 %が「希望しない」と回答．希望する群は希望しない群と比較し有意に年齢が若く，男性が多く，糖尿病治療薬の種類が多かった．本検討から糖尿病患者ではポリファーマシー率が高く，週1回製剤の希望者は少なくはなく，その特徴として若年，男性，糖尿病治療薬数が多いことが示された．
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日本糖尿病学会"}],"prism:publicationDate":"2017","prism:volume":"60","prism:number":"12","prism:startingPage":"783","prism:endingPage":"790"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2018110046"}],"availableAt":"2017","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%9D%E3%83%AA%E3%83%95%E3%82%A1%E3%83%BC%E3%83%9E%E3%82%B7%E3%83%BC%EF%BC%88%E8%A8%98%E8%BC%89%E3%81%AA%E3%81%97%EF%BC%89","dc:title":"ポリファーマシー（記載なし）"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%80%B11%E5%9B%9E%E8%A3%BD%E5%89%A4%EF%BC%88%E8%A8%98%E8%BC%89%E3%81%AA%E3%81%97%EF%BC%89","dc:title":"週1回製剤（記載なし）"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%A2%E3%83%89%E3%83%92%E3%82%A2%E3%83%A9%E3%83%B3%E3%82%B9","dc:title":"アドヒアランス"},{"@id":"https://cir.nii.ac.jp/all?q=DPP-4%E9%98%BB%E5%AE%B3%E8%96%AC","dc:title":"DPP-4阻害薬"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2003548479"},{"@type":"CIA","@value":"130006295175"}]}