{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679908516864.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/oxfordjournals.jbchem.a003189"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BD38XmslCiu74%3D"}},{"identifier":{"@type":"PMID","@value":"12097169"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6262656"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6262656"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6262656"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/jb/article-pdf/132/1/127/2650326/132-1-127.pdf"}},{"identifier":{"@type":"NAID","@value":"130003418016"}},{"identifier":{"@type":"NAID","@value":"50000577945"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2003009654"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"The Proprotein Convertase PACE4 Is Upregulated by PDGF-BB in Megakaryocytes: Gene Expression of PACE4 and Furin Is Regulated Differently in Dami Cells."},{"@language":"ja-Kana","@value":"Proprotein Convertase PACE4 Is Upregulated by PDGF BB in Megakaryocytes Gene Expression of PACE4 and Furin Is Regulated Differently in Dami Cells"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The differentiation of megakaryocytes into platelets is highly regulated by many cytokines and growth factors. PACE4 and furin are Ca<sup>2+</sup>-dependent serine endoproteases belonging to the subtilisin-like proprotein convertase (SPC) family. These enzymes are involved in the proteolytic activation of proteins that play essential roles in cell growth and differentiation. In this study, we examined the expression of PACE4 and furin during the differentiation of megakatyoblastic cell lines, Dami and HEL cells, induced by phorbol 12-myristate 13-acetate (PMA). PMA stimulates not only the expression of platelet-derived growth factor-B (PDGF-B) mRNA, but also PACE4 mRNA in these cell lines. The expression of PACE4 transcripts (both the PACE4A and PACE4C/CS isoforms) was upregulated more than 4-fold by PMA. Moreover, direct treatment with PDGF-BB also resulted in an increase in the level of PACE4 mRNA. Further, the effect of PDGF-BB on PACE4 expression was confirmed by promoter assay of the PACE4 gene. Although the furin mRNA level was increased by TGF-/β1 in Dami cells, it was not affected by PDGF-BB. These results indicate for the first time that PACE4 expression is specifically upregulated by PDGF-BB in differentiated megakaryoblasts, suggesting a unique role for PACE4 in platelet production."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679908516865","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252815100"}],"foaf:name":[{"@language":"en","@value":"Bando Miwa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679908516864","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000011052396"},{"@type":"NRID","@value":"9000252815101"}],"foaf:name":[{"@language":"en","@value":"Matsuoka Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658352640640","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20155360"},{"@type":"NRID","@value":"1000020155360"},{"@type":"NRID","@value":"9000006868107"},{"@type":"NRID","@value":"9000004722185"},{"@type":"NRID","@value":"9000004708774"},{"@type":"NRID","@value":"9000394472812"},{"@type":"NRID","@value":"9000253470199"},{"@type":"NRID","@value":"9000391636487"},{"@type":"NRID","@value":"9000253198677"},{"@type":"NRID","@value":"9000253176376"},{"@type":"NRID","@value":"9000004248945"},{"@type":"NRID","@value":"9000004458757"},{"@type":"NRID","@value":"9000391637618"},{"@type":"NRID","@value":"9000253204294"},{"@type":"NRID","@value":"9000006631308"},{"@type":"NRID","@value":"9000253200205"},{"@type":"NRID","@value":"9000398022713"},{"@type":"NRID","@value":"9000253200923"},{"@type":"NRID","@value":"9000018568568"},{"@type":"NRID","@value":"9000391641620"},{"@type":"NRID","@value":"9000391616124"},{"@type":"NRID","@value":"9000391620128"},{"@type":"NRID","@value":"9000252815102"},{"@type":"NRID","@value":"9000018988392"},{"@type":"NRID","@value":"9000022203125"},{"@type":"NRID","@value":"9000252811398"},{"@type":"NRID","@value":"9000394472802"},{"@type":"NRID","@value":"9000253199925"},{"@type":"NRID","@value":"9000006868501"},{"@type":"NRID","@value":"9000391641877"},{"@type":"NRID","@value":"9000253184168"},{"@type":"NRID","@value":"9000017714938"},{"@type":"NRID","@value":"9000017713417"},{"@type":"NRID","@value":"9000399531232"},{"@type":"NRID","@value":"9000391648777"},{"@type":"NRID","@value":"9000391605463"},{"@type":"NRID","@value":"9000391616469"},{"@type":"NRID","@value":"9000252814445"},{"@type":"NRID","@value":"9000252815591"},{"@type":"NRID","@value":"9000253174284"},{"@type":"NRID","@value":"9000399542409"},{"@type":"NRID","@value":"9000394472790"},{"@type":"NRID","@value":"9000391616446"},{"@type":"NRID","@value":"9000253203696"},{"@type":"NRID","@value":"9000252813475"},{"@type":"NRID","@value":"9000253164729"},{"@type":"NRID","@value":"9000253178918"},{"@type":"NRID","@value":"9000019252754"},{"@type":"NRID","@value":"9000394472797"},{"@type":"NRID","@value":"9000253204264"},{"@type":"NRID","@value":"9000253178978"},{"@type":"NRID","@value":"9000253171291"},{"@type":"NRID","@value":"9000021295201"},{"@type":"NRID","@value":"9000252900260"},{"@type":"NRID","@value":"9000021856244"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tsujiakihiko"}],"foaf:name":[{"@language":"en","@value":"Tsuji Akihiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679908516866","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000252815103"}],"foaf:name":[{"@language":"en","@value":"Matsuda Yoshiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0021924X"},{"@type":"EISSN","@value":"17562651"},{"@type":"NDL_BIB_ID","@value":"000000119499"},{"@type":"ISSN","@value":"0021924X"},{"@type":"LISSN","@value":"0021924X"},{"@type":"NCID","@value":"AA00694073"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of Biochemistry"},{"@language":"en","@value":"J Biochem (Tokyo)"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Biochemical Society"},{"@language":"ja","@value":"社団法人 日本生化学会"}],"prism:publicationDate":"2002","prism:volume":"132","prism:number":"1","prism:startingPage":"127","prism:endingPage":"134"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/6262656"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6262656"},{"@id":"http://academic.oup.com/jb/article-pdf/132/1/127/2650326/132-1-127.pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2003009654"}],"availableAt":"2002","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=megakaryocytes","dc:title":"megakaryocytes"},{"@id":"https://cir.nii.ac.jp/all?q=PACE4","dc:title":"PACE4"},{"@id":"https://cir.nii.ac.jp/all?q=PDGF-BB","dc:title":"PDGF-BB"},{"@id":"https://cir.nii.ac.jp/all?q=proprotein%20convertase","dc:title":"proprotein convertase"},{"@id":"https://cir.nii.ac.jp/all?q=transcriptional%20regulation","dc:title":"transcriptional regulation"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360299773107018624","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"A Critical Role for the Carboxy Terminal Region of the Proprotein Convertase, PACE4A, in the Regulation of Its Autocatalytic Activation Coupled with Secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569874529024","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities."}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994605475712","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides1Published on the World Wide Web on 17 August 1999.1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994830444544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Highly Regulated Expression of Subtilisin-like Proprotein Convertase PACE4 (SPC4) during Dentinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995715472512","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470748212864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420839792384","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Developmental roles of platelet‐derived growth factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421072035200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium."}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896379936256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368742039296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Induced differentiation of K562 leukemia cells: A model for studies of gene expression in early megakaryoblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318283458560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"A synthetic inhibitor of the mitogen-activated protein kinase cascade."}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319150099328","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Signaling Networks—Do All Roads Lead to the Same Genes?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795939139456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Proprotein cleavage of E‐cadherin by furin in baculovirus over‐expression system: potential role of other convertases in mammalian cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204929941376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genomic Organization and Alternative Splicing of Human PACE4 (SPC4), Kexin-Like Processing Endoprotease."},{"@language":"ja-Kana","@value":"Genomic Organization and Alternative Sp"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679909108096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Novel Human PACE4 Isoform, PACE4E Is an Active Processing Protease Containing a Hydrophobic Cluster at the Carboxy Terminus."},{"@language":"ja-Kana","@value":"Novel Human PACE4 Isoform PACE4E Is an"}]},{"@id":"https://cir.nii.ac.jp/crid/1521980704779813248","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation"},{"@language":"ja-Kana","@value":"Subtilisin like proprotein convertase PACE4 is required for skeletal muscle differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1521980705208374272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Subtilisin-Like Proprotein Convertases,PACE4 and PC8,as Well as Endogenous Proalbumin Convertases in HepG2 Cells"},{"@language":"ja-Kana","@value":"Subtilisin-Like Proprotein Convertases PACE4 and PC8 as Well as Endogenous Proalbumin Convertases in HepG2 Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749895132288","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749895133568","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tissue-specific requirements for the proprotein convertase Furin/SPC1 during embryonic turning and heart looping"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749895135360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Platelet-derived growth factor enhances in vitro erythropoiesis via stimulation of mesenchymal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009751749134592","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The murine transforming growth factor-beta precursor"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291224207507840","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"PDGF-AA and PDGF-BB biosynthesis : proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699371925376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distribution of the Kexin family proteases in pancreatic islets : PACE4C is specifically expressed in B cells of pancreatic islets"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699848554112","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"TGFβ1 regulates gene expression of its own converting enzyme furin"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699848555904","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The regulation of megakaryocytopoiesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854174825264640","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Platelet-derived growth factor enhances granulopoiesis via bone marrow stromal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854175829744384","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Furin : A mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854176695318912","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY-294002)"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649801977216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649801978880","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of the dibasic proprotein processing enzyme furin is directed by multiple promoters"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651392015232","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endoprotease activities other than furin and PACE4 with a role in processing of HIV-I gp160 glycoproteins in CHO-K1 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126647887872","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126650978688","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1571698599755398016","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SPC4/PACE4 regulates a TGFβ signaling network during axis formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599755399424","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Detection and quantification of transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) release by normal human megakaryocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600602834432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The developmental expression in the rat CNS and peripheral tissues of proteases PC5 and PACE4 mRNAs : comparison with other proprotein processing enzymes"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074732109056","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Signal transduction via platelet-derived growth factor receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074732110208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of megakaryocytopoiesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549708817664","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Human subtilisin-like proprotein convertase, PACE4 (SPC4) gene expression is highly regulated through E-box elements in HepG2 and GH4C1 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549708821248","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of PDGF receptors on human megakaryocytes and megakaryocytic cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543025695890176","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functional analysis of human PACE4-A and PACE4-C isoforms : identification of a new PACE4-CS isoform"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499404299520","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recombinant PDGF enhances megakaryocytopoiesis in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499662238720","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499662240000","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499662241408","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Characterization of a new megakaryocytic cell line : the Dami cell"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499662242688","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of selectivity of α1-antitrypsin variant by mutagenesis in its reactive site loop against proprotein convertase. A crucial role of the P4 arginine in PACE4 inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824500995659776","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Involvement of Smads in TGFβ1-induced furin (fur) transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824501522238592","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974160692224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974638949376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974638950784","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Platelet-derived growth factor promotes proliferation of erythropoietic progenitor cells in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974638951808","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hematopoietic factor-induced synthesis of von Willebrand factor by the Dami human megakaryoblastic cell line and by normal human megakaryocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974638952960","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evidence that furin is an authentic transforming growth factor-β1-converting enzyme"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976482078720","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449615661184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Platelet-derived growth factor : phorbol ester induces the expression of the B-chain but not of the A-chain in HEL cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449615662208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Regulation of megakaryocytopoiesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924115716864","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668925832717184","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Subtilase-like proprotein convertases : from molecular specificity to therapeutic applications"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668926470368640","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950398814730368","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HEL cells : a new human erythroleukemia cell line with spontaneous and induced globin expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399569081856","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399569082880","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endoprotease PACE4 is Ca^<2+>-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400572277504","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401478985216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874545792768","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Wortmannin, a potent and selective inhibitor of phosphatidylinositol 3-kinase"},{"@value":"Wortmannin, a potent and selective inhibitor of phosphatidylinositol‐3‐kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874545793920","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transfroming growth factor-β1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874545796224","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanism of action and in vivo role of platelet-derived growth factor"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0015411262"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I6262656"},{"@type":"CROSSREF","@value":"10.1093/oxfordjournals.jbchem.a003189"},{"@type":"PUBMED","@value":"12097169"},{"@type":"CIA","@value":"50000577945"},{"@type":"CIA","@value":"130003418016"},{"@type":"OPENAIRE","@value":"doi_dedup___::dcaeb4432699ecf7edd7661d7db9dd9f"}]}