Antigen-specific therapy in myasthena gravis.

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  • 重症筋無力症の抗原特異的免疫吸着療法　ＩＩ　　アセチルコリン受容体合成ペプチドの病的免疫原性検定とその臨床応用
  • アセチルコリン受容体合成ペプチドの病的免疫原性検定とその臨床応用

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Description

Based on the availability of amino acid sequence of Torpedo acetylcholine receptor, the segment α 183-200 was synthesized and used for an antigen-specific therapy in myasthenia gravis. This synthetic peptide was confirmed to be immunogenic in the induction of the animal model of immunopharmacological blokade and also antigenic in the detection of antibody in human myasthenic sera. Two patients, who had high titers of anti-peptide antibody, were treated with the plasmaperfusion by use of the peptide-bound adsorbent on 2 consecutive days. This treatment specaficically reduced the corresponding anti-peptide antibody, and also provided an improvement for myasthhnic state as estimated by electrophysioloic parameters of neuromusular transmission.

Journal

  • Jinko Zoki

    Jinko Zoki 18 (1), 19-23, 1989

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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