{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679954802432.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15036/arerugi.44.1207"}},{"identifier":{"@type":"NAID","@value":"110002424641"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1996156550"}}],"dc:title":[{"@language":"ja","@value":"小児気管支喘息におけるゴキブリアレルゲン陽性率とその抗原性の検討"},{"@language":"en","@value":"STUDY OF COCKROACH ALLERGY IN ASTHMATIC CHILDREN : The Positive Rates and Antigenicity of Cockroach Allergen"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The specific IgE antibodies to 4 species of cockroach were measured in sera from 51 asthmatic children 6 to 16 years old by RAST and CAP system. Positive rates of RAST to Periplaneta fuliginosa, Blattela germanica, Periplaneta americana and Periplaneta japonica were 17.6%, 29.4%, 19.6% and 15.7%, respectively and those of CAP system to Periplaneta fuliginosa and Blattela germanica were 15.7%, respectively. Among those with positive RAST to 4 species of cockroach there were significant correlations. Significant correlations were observed also between the RAST titer for the whole bodies and feces of Periplaneta fuliginosa and Blattela germanica and immunoblotting analysis of sera obtained from two cockroach-positive patients revealed common sensitive fraction between whole body and feces. Immediate bronchial response was detected by bronchial provocation test. RAST inhibition study indicated no cross-reacting allergenicity between cockroach and mite. Collectively, cockroach is one of important inhalent allergens in asthmatic children."},{"@language":"ja","@value":"6〜16歳の気管支喘息児51名において4種のゴキブリ特異IgE抗体をRASTおよびCAP-RASTにて測定した. ゴキブリ特異IgE抗体陽性率はRASTでクロゴキブリ17.6%, チャバネゴキブリ29.4%, ワモンゴキブリ19.6%, ヤマトゴキブリ15.7%であり, CAP-RASTではクロゴキブリ, チヤバネゴキプリとも15.7%であった. また, この4種のゴキブリRASTを陰性と陽性に分けて検討すると相関関係が認められた. クロゴキブリおよびチャバネゴキプリ虫体と糞のRASTは相関関係を認め, 2名のゴキブリ陽性患児血清を用いた. immunoblot法では虫体と糞に共通の感作抗原分画を認めた. ゴキブリ抗原吸入誘発試験では既時型の気道反応を示し, RAST抑制試験ではゴキブリ抗原によりダニRASTは抑制されなかった. 以上より小児気管支喘息においてゴキブリはダニとは異なる吸入性アレルゲンとして注目すべきと考えらられた."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030566608385591424","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70260552"},{"@type":"NRID","@value":"1000070260552"},{"@type":"NRID","@value":"9000008185982"},{"@type":"NRID","@value":"9000022085681"},{"@type":"NRID","@value":"9000253534829"},{"@type":"NRID","@value":"9000258118195"},{"@type":"NRID","@value":"9000265257002"},{"@type":"NRID","@value":"9000258056610"},{"@type":"NRID","@value":"9000255816182"},{"@type":"NRID","@value":"9000256383298"},{"@type":"NRID","@value":"9000256383437"},{"@type":"NRID","@value":"9000255911398"}],"foaf:name":[{"@language":"ja","@value":"尾上 洋一"},{"@language":"en","@value":"Onoue Yoichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学小児科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802437","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"村上 巧啓"},{"@language":"en","@value":"Murakami Gyoukei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Toyama Red Cross Hospital"},{"@language":"ja","@value":"富山赤十字病院小児科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802436","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"高柳 幹"},{"@language":"en","@value":"Takayanagi Miki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学小児科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802438","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"岩谷 雅子"},{"@language":"en","@value":"Iwaya Masako"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学小児科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802435","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"萱原 昌子"},{"@language":"en","@value":"Kayahara Masako"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学小児科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802433","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"足立 陽子"},{"@language":"en","@value":"Adachi Yohko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学小児科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802434","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"松野 正知"},{"@language":"en","@value":"Matsuno Masatomo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Niigata Prefectural Yoshida Hospital"},{"@language":"ja","@value":"新潟県立吉田病院小児科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679954802439","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"足立 雄一"},{"@language":"en","@value":"Adachi Yuichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University"},{"@language":"ja","@value":"富山医科薬科大学小児科学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00214884"},{"@type":"LISSN","@value":"00214884"},{"@type":"EISSN","@value":"13477935"},{"@type":"NCID","@value":"AN00012583"}],"prism:publicationName":[{"@language":"ja","@value":"アレルギー"},{"@language":"en","@value":"Japanese Journal of Allergology"},{"@language":"ja","@value":"アレルギー"},{"@language":"en","@value":"Japanese Journal of Allergology"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Allergology"},{"@language":"ja","@value":"一般社団法人 日本アレルギー学会"}],"prism:publicationDate":"1995","prism:volume":"44","prism:number":"10","prism:startingPage":"1207","prism:endingPage":"1215"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/1996156550"}],"availableAt":"1995","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=bronchial%20asthma","dc:title":"bronchial asthma"},{"@id":"https://cir.nii.ac.jp/all?q=cockroach","dc:title":"cockroach"},{"@id":"https://cir.nii.ac.jp/all?q=specific%20IgE","dc:title":"specific IgE"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360855571330132736","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Allergy to insects in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421299118976","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Insect allergy—Preliminary studies of the cockroach"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204970409088","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ゴキブリ喘息の1例"},{"@language":"en","@value":"A Case of Cockroach Asthma"},{"@language":"ja-Kana","@value":"ゴキブリ ゼンソク ノ 1レイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204985596928","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"成人気管支喘息患者におけるゴキブリアレルゲンの検討"},{"@language":"en","@value":"STUDY OF COCKROACH ALLERGEN IN ADULT ASTHMATICS IN JAPAN"},{"@language":"ja-Kana","@value":"セイジン キカンシ ゼンソク カンジャ ニ オケル ゴキブリアレルゲン ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205006913152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nationwide Investigation of Insect Allergy in Patients with Allergic 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