{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679957538176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15036/arerugi.49.358"}},{"identifier":{"@type":"NAID","@value":"110002426382"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2000248798"}}],"dc:title":[{"@language":"ja","@value":"成人の気管支喘息の急性増悪におけるピコルナウイルス(ライノウイルス)感染の関与 : RT-PCR法を用いた検討"},{"@language":"en","@value":"THE CORRELATION BETWEEN THE EXACERBATION OF BRONCHIAL ASTHMA AND PICORNAVIRUS(HUMAN RHINO VIRUS)INFECTION : IN THROAT GARGLES BY RT-PCR"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Viral infection is one of important factors to cause the exacerbation of bronchial asthma. We have investigated 167 adults of asthmatics to clarify the correlation between viral infection and exacerbation of asthma. Patients were classificated to four group by the symptoms of common cold and asthma attack. Furthermore, We have examined Picornavirus and Human rhino virus RNA from throat gargles of patients using RT-PCR(reverse transcription-polymerase chain reaction)method. Forty of 65(61.5%)asthmatics with common cold revealed asthma attack and common cold was significantly associated with acute exacerbation of asthma(p<0.01). We identified Picornavirus RNA, which include 113 of Human rhino virus serotypes and enterovirus, from the samples of 16 of 52(30.8%)patients who had acute exacerbation.It was significantly higher than the detection rate of viral RNA from patient without asthma attack. Furthermore, we analyzed Human rhino virus RNA from the same samples by RT-PCR and 93.7% of Picornavirus were identified as Human rhino virus. Taken together, these findings suggest that common cold is significantly associated with the exacerbation of bronchial asthma. Human rhino virus infection might be one of important virus in this procedure."},{"@language":"ja","@value":"成人気管支喘息の急性増悪におけるウイルス感染の関与を明確にする目的で喘息患者167名を対象に感冒症状, 喘息発作の有無別に4群に分類して9カ月間調査した.さらに咽頭うがい液を採取しRT-PCR法を用いてピコルナウイルス, ライノウイルスを検出して, その関連性を検討した.感冒症状を認めた65例のうち喘息急性増悪を認めた症例は40例(61.5%)と高率であった(p<0.01).113種のライノウイルスおよびエンテロウイルスを含むピコルナウイルスを標的にしたRT-PCR法を用いた検討では, 喘息の急性増悪群52例のうち16例(30.8%)にピコルナウイルスが検出され, 喘息発作陰性群115例のうちの12例(10.4%)と比較して有意に高率であった(p<0.01).急性増悪の原因となるウイルスをさらにライノウイルスに絞り再度RT-PCR法を用いて検討した結果, ピコルナウイルス陽性群16例のうち15例(93.7%)と殆どがライノウイルスの関与であった.以上より成人気管支喘息の急性増悪の原因として感冒が重要な因子であり, かつライノウイルス感染との関連性が示唆された."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679957538048","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"久賀 秀樹"},{"@language":"en","@value":"Kuga Hideki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Public Health, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学公衆衛生学教室:昭和大学第一内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679957538178","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"今井 俊道"},{"@language":"en","@value":"Imai Toshimichi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Infernal Medicine, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学第一内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679957538176","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"星山 佳治"},{"@language":"en","@value":"Hoshiyama Yoshiharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Public Health, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学公衆衛生学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1030848083698993152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"21390254"},{"@type":"NRID","@value":"1000021390254"},{"@type":"NRID","@value":"9000020463761"},{"@type":"NRID","@value":"9000316692151"},{"@type":"NRID","@value":"9000345273958"},{"@type":"NRID","@value":"9000018484715"},{"@type":"NRID","@value":"9000020102725"},{"@type":"NRID","@value":"9000253630378"},{"@type":"NRID","@value":"9000368417381"},{"@type":"NRID","@value":"9000000865272"},{"@type":"NRID","@value":"9000020994758"},{"@type":"NRID","@value":"9000391421892"},{"@type":"NRID","@value":"9000020319439"},{"@type":"NRID","@value":"9000356503750"},{"@type":"NRID","@value":"9000253629280"},{"@type":"NRID","@value":"9000253632739"},{"@type":"NRID","@value":"9000021642105"},{"@type":"NRID","@value":"9000020905873"},{"@type":"NRID","@value":"9000283774802"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0186325"}],"foaf:name":[{"@language":"ja","@value":"國分 二三男"},{"@language":"en","@value":"Kokubu Fumio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Infernal Medicine, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学第一内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801205066880","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10384231"},{"@type":"NRID","@value":"1000010384231"},{"@type":"NRID","@value":"9000002892087"},{"@type":"NRID","@value":"9000021058605"},{"@type":"NRID","@value":"9000258296181"},{"@type":"NRID","@value":"9000368417380"},{"@type":"NRID","@value":"9000345218168"},{"@type":"NRID","@value":"9000391421887"},{"@type":"NRID","@value":"9000384274601"},{"@type":"NRID","@value":"9000020319449"},{"@type":"NRID","@value":"9000356503745"}],"foaf:name":[{"@language":"ja","@value":"松倉 聡"},{"@language":"en","@value":"Matsukura Satoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Infernal Medicine, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学第一内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658538682368","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50365748"},{"@type":"NRID","@value":"1000050365748"},{"@type":"NRID","@value":"9000010426431"},{"@type":"NRID","@value":"9000258296179"},{"@type":"NRID","@value":"9000001211760"},{"@type":"NRID","@value":"9000391658435"},{"@type":"NRID","@value":"9000413523640"},{"@type":"NRID","@value":"9000240058314"},{"@type":"NRID","@value":"9000273019620"},{"@type":"NRID","@value":"9000257947378"},{"@type":"NRID","@value":"9000413479361"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0140721"}],"foaf:name":[{"@language":"ja","@value":"川口 未央"},{"@language":"en","@value":"Kawaguchi Miou"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Infernal Medicine, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学第一内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679957538177","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"徳永 久博"},{"@language":"en","@value":"Tokunaga Hisahiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Infernal Medicine, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学第一内科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679957538180","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"川口 毅"},{"@language":"en","@value":"Kawaguchi Takeshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Public Health, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学公衆衛生学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679957538182","@type":"Researcher","foaf:name":[{"@language":"ja","@value":"足立 満"},{"@language":"en","@value":"Adachi Mitsuru"}],"jpcoar:affiliationName":[{"@language":"en","@value":"First Department of Infernal Medicine, University of Showa School of Medicine"},{"@language":"ja","@value":"昭和大学第一内科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00214884"},{"@type":"LISSN","@value":"00214884"},{"@type":"EISSN","@value":"13477935"},{"@type":"NCID","@value":"AN00012583"}],"prism:publicationName":[{"@language":"ja","@value":"アレルギー"},{"@language":"en","@value":"Japanese Journal of Allergology"},{"@language":"ja","@value":"アレルギー"},{"@language":"en","@value":"Japanese Journal of Allergology"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Allergology"},{"@language":"ja","@value":"一般社団法人 日本アレルギー学会"}],"prism:publicationDate":"2000","prism:volume":"49","prism:number":"4","prism:startingPage":"358","prism:endingPage":"364"},"url":[{"@id":"https://search.jamas.or.jp/link/ui/2000248798"}],"availableAt":"2000","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=bronchial%20asthma","dc:title":"bronchial asthma"},{"@id":"https://cir.nii.ac.jp/all?q=human%20rhino%20virus","dc:title":"human rhino virus"},{"@id":"https://cir.nii.ac.jp/all?q=reverse%20transcription","dc:title":"reverse transcription"},{"@id":"https://cir.nii.ac.jp/all?q=polymerase%20chain%20reaction","dc:title":"polymerase chain reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Picornavirus","dc:title":"Picornavirus"},{"@id":"https://cir.nii.ac.jp/all?q=throat%20gargle","dc:title":"throat gargle"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204633264768","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prevention of Asthma Exacerbation with Vaccination against Influenza in Winter Season"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204984805632","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"気管支喘息の病態と治療 21世紀の展望"},{"@language":"en","@value":"PATHOGENESIS AND TREATMENT OF BRONCHIAL ASTHMA-TREND FOR 21st CENTURY"},{"@language":"ja-Kana","@value":"キカンシ ゼンソク ノ ビョウタイ ト チリョウ 21セイキ ノ テンボウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679965974912","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"ウイルス感染と気管支喘息"},{"@language":"en","@value":"RESPIRATORY VIRUSES AND BRONCHIAL ASTHMA"},{"@language":"ja-Kana","@value":"ウイルス カンセン ト キカンシ ゼンソク"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749420299776","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Abiological model to explain the association between human rhinovirus respiratory infections and bronchial asthma."}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749420305792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without resiratory 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reaction."}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599280563328","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Infection of human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure."}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599280565632","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association of viral and mycoplasma in fections with exacerbations of asthma."}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599280566784","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Rhinovirus uper respiratory infection increases airway hyperreactiviy and late asthmatic reaction."}]},{"@id":"https://cir.nii.ac.jp/crid/1571698599280568192","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through induction of IFN-β and IL-1 α."}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074257274880","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The relationship between upper respiratory infections and hospital admisions for asthma: A time-trend analysis."}]},{"@id":"https://cir.nii.ac.jp/crid/1571980074257276032","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Respiratory syncytial virus-induced cytokine production by a human bronchial epithelial cell line"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549233985792","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The clinical picture of Far-East influenza occurring at the 4th National Boy Scout Jamboree."}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549233986944","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interleukin-8 expression in normal nasal epithelium and its modulation by infection with respiratory syncytial virus and cytokines tumor necrosis factor, interleukin-1 and interleukin-6."}]},{"@id":"https://cir.nii.ac.jp/crid/1572261549233990400","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Viral and bacterial infections in adults with chronic asthma."}]},{"@id":"https://cir.nii.ac.jp/crid/1572261551602307072","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Community study of role of viral infections in exacerbation os asthma in 9-11 year old children."}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024210698624","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Viruses and bacteria in the etiology of the common cold."}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024210700544","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Respiratory virus and exacerbations of asthma in adults."}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499187264000","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of RANTES by normal airway epithelial cells after influenza virus A infection."}]},{"@id":"https://cir.nii.ac.jp/crid/1573950400570847616","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"気管支喘息とウイルス感染"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950401410119680","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The major human rhinovirus receptor is ICAM-1."}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875909697280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Improved detection of rhinovirus in nasal and throat swabs by seminested RT-PCR."}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:2001813348"},{"@type":"CIA","@value":"110002426382"}]}