{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390282679979640320.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11400/kekkaku1923.55.423"}},{"identifier":{"@type":"PMID","@value":"6968848"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"2224015"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/2224015"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I2224015"}},{"identifier":{"@type":"NAID","@value":"130001415236"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1981041477"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"IMMUNOLOGICAL STUDY ON HUMAN TUBERCULOSIS AT THE CELLULAR LEVEL"},{"@value":"ヒトの結核免疫に関する細胞生物学的研究"},{"@language":"ja-Kana","@value":"ヒト ノ ケッカク メンエキ ニ カンスル サイボウ セイブツガクテキ ケンキ"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"It was found that there were two different subsets of thymus derived T lymphocytes when lympho cytes from patients with tuberculosis were stimulated in vitro with tuberculin purified protein derivative, PPD. The one was IgG Fc-receptor bearing T cells (T<SUB>G</SUB>) and the other was rosette forming T cells with autologous erythrocytes. Both of which are supposed to play an important role not only in the induction of tuberculin hypersensitivity but also in immunity to tuberculosis.<BR>1) Increase in IgG Fc-receptor bearing T cells (T<SUB>G</SUB>) in PBL of tuberculous patients by the in vitro stimulation with PPD<BR>A mixed rosette technique with sheep erythrocytes and chicken erythrocytes coated with heat aggregated human IgG was employed to identify human peripheral blood T lymphocytes bearing IgG Fc-receptor (T<SUB>G</SUB>). When peripheral blood lymphocytes (PBL) from patients with advanced, refrac tory tuberculosis were stimulated in vitro with PPD, increase in the number of T<SUB>G</SUB> cells was observed, whereas no such T<SUB>G</SUB> cells were developed in PBL from newly diagnosed tuberculous patients after the stimulation with PPD. T<SUP>G </SUP> cells isolated from the tuberculin skin test positive individual by the method of velocity sedimentation suppressed PPD-induced proliferative response of autologous PBL, as well as the pokeweed mitogen-induced IgG synthesis by B cells.<BR>2) PPD-stimulated development in tuberculosis of T cells bearing receptors for autologous erythrocytes Tuberculous human lymphocytes activated in vitro with tuberculin PPD were examined for rosette formation with autologous erythrocytes. The autorosette forming cell (auto-RFC) levels were strongly enhanced when pleural fluid lymphocytes and, to a lesser extent, PBL of the patients with tuberculosis were stimulated in vitro with PPD, whereas no increase in auto-RFC was observed in PBL from tuberculin skin test negative healthy individuals. These auto-RFC developed were shown to rosette with sheep erythrocytes and, therefore, belong to a T cell subset. It was also shown that adherent cells were required for the development of auto-RFC by the stimulation with PPD. Deple tion of PPD-stimulated auto-RFC by the velocity sedimentation technique led to a significant de crease in PPD reactivity assessed by the proliferation or auto-RFC formation.led to a significant de crease in PPD reactivity assessed by the proliferation or auto-RFC formation."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410853647016082432","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020561175"}],"foaf:name":[{"@language":"en","@value":"TSUYUGUCHI Izuo"},{"@language":"ja","@value":"露口 泉夫"}],"jpcoar:affiliationName":[{"@language":"en","@value":"From the Osaka Prefectural Habikino Hospital"},{"@language":"ja","@value":"大阪府立羽曳野病院"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00229776"},{"@type":"LISSN","@value":"00229776"},{"@type":"EISSN","@value":"18842410"},{"@type":"NDL_BIB_ID","@value":"000000006682"},{"@type":"ISSN","@value":"00229776"},{"@type":"NCID","@value":"AN00073442"}],"prism:publicationName":[{"@language":"en","@value":"Kekkaku(Tuberculosis)"},{"@language":"ja","@value":"結核"},{"@language":"en","@value":"Kekkaku(Tuberculosis)"},{"@language":"ja","@value":"結核"}],"dc:publisher":[{"@language":"en","@value":"THE JAPANESE SOCIETY FOR TB AND NTM"},{"@language":"ja","@value":"一般社団法人 日本結核・非結核性抗酸菌症学会"}],"prism:publicationDate":"1980","prism:volume":"55","prism:number":"9","prism:startingPage":"423","prism:endingPage":"427"},"url":[{"@id":"http://id.ndl.go.jp/bib/2224015"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I2224015"},{"@id":"https://search.jamas.or.jp/link/ui/1981041477"}],"availableAt":"1980","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0037908761"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I2224015"},{"@type":"PUBMED","@value":"6968848"},{"@type":"CIA","@value":"130001415236"}]}