あらかじめ傷害された組織における非定型抗酸菌の病原性に関する研究

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書誌事項

タイトル別名
  • STUDIES ON THE PATHOGENECITY OF UNCLASSIFIED MYCOBACTERIA IN INJURED TISSUES
  • アラカジメ ショウガイ サレタ ソシキ ニ オケル ヒテイケイ コウサンキン ノ ビョウゲンセイ ニ カンスル ケンキュウ

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説明

This study deals with the pathogenecity in injured tissues of unclassified mycobacteria known as low virulent organisms. Albino dd/y female mice weighing 17 gm. were used and their tissues were injured as in the following with: 1)aseptic abscess induced by oil of turpentine, 2) purulent renal abscess induced by staphylococcus aureus, 3) allergic injury in the lung and the kidney which was induced by subcutaneous injections of anti-mouse lung immune rabbit serum and anti-mouse kidney immune rabbit serum. Photochromogen strains P-8 and P1, nonphotochromogen strain P-7 and scotochromogen strain P-6 were inoculated into the abscesses or given intravenously, and the rate of survival of those strains were estimated by serial cultivations from the abscesses or the organs.<BR>The results were as follows;<BR>1) The unclassified mycobact e ria given into aseptic abscesses survived for three to four weeks, showing no significant difference in their survival time from those injected into thenoninjured subcutaneous tissues.<BR>2) The intravenously inoculated organisms were recovered from the aseptic subcutaneous. abscesses for two to three weeks. Especially viable units of photochromogens from the abscesses increased during two weeks after the intravenous inoculation.<BR>3) From the lungs with aseptic abscesses more organisms of photochromogen inoculated_intravenously were recovered than from normal lungs of the same animals.<BR>4) Prolongation of survival time of the organisms inoculated intra v enously was not observed_in the mice with staphylococcal abscess.<BR>5) On treating with anti-mou s e lung or kidney immune rabbit serum, from lungs and kidneys of the treated animals photochromogen inoculated intravenously was recovered two to three times more than from those of normal animals. Elimination of inoculated nonphotochromogen was slower in organs of the animals treated with immune serum than in those of normal animals.

収録刊行物

  • 結核

    結核 41 (3), 127-135, 1966

    一般社団法人 日本結核病学会

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